Search Results - "Ernst, Patrick"

Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins by Dunne, Matthew, Rupf, Beatrice, Tala, Marc, Qabrati, Xhem, Ernst, Patrick, Shen, Yang, Sumrall, Eric, Heeb, Laura, Plückthun, Andreas, Loessner, Martin J., Kilcher, Samuel

“…Bacteriophages provide excellent tools for diagnostics, remediation, and targeted microbiome manipulation, yet isolating viruses with suitable host specificity…”
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Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation by Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, Allain, Frédéric H. T., Polymenidou, Magdalini

“…TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with…”
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control by Schmid, Markus, Ernst, Patrick, Honegger, Annemarie, Suomalainen, Maarit, Zimmermann, Martina, Braun, Lukas, Stauffer, Sarah, Thom, Cristian, Dreier, Birgit, Eibauer, Matthias, Kipar, Anja, Vogel, Viola, Greber, Urs F., Medalia, Ohad, Plückthun, Andreas

“…Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate and adaptive immunity, and silencing of therapeutic…”
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Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice by Zhao, Meng, Fan, Chengming, Ernst, Patrick J, Tang, Yawen, Zhu, Hanxi, Mattapally, Saidulu, Oduk, Yasin, Borovjagin, Anton V, Zhou, Lufang, Zhang, Jianyi, Zhu, Wuqiang

“…Abstract Aims  The effectiveness of cell-based treatments for regenerative myocardial therapy is limited by low rates of cell engraftment. Y-27632 inhibits…”
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Structural analysis of biological targets by host:guest crystal lattice engineering by Ernst, Patrick, Plückthun, Andreas, Mittl, Peer R. E.

“…To overcome the laborious identification of crystallisation conditions for protein X-ray crystallography, we developed a method where the examined protein is…”
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Characterization of the far-red fluorescent probe MitoView 633 for dynamic mitochondrial membrane potential measurement by Ernst, Patrick, Kim, Seulhee, Yang, Zengqiao, Liu, Xiaoguang Margaret, Zhou, Lufang

“…MitoView 633, a far-red fluorescent dye, exhibits the ability to accumulate within mitochondria in a membrane potential-dependent manner, as described by the…”
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Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action by Kast, Florian, Schwill, Martin, Stüber, Jakob C., Pfundstein, Svende, Nagy-Davidescu, Gabriela, Rodríguez, Josep M. Monné, Seehusen, Frauke, Richter, Christian P., Honegger, Annemarie, Hartmann, Karen Patricia, Weber, Thomas G., Kroener, Felix, Ernst, Patrick, Piehler, Jacob, Plückthun, Andreas

“…The receptor tyrosine kinase HER2 acts as oncogenic driver in numerous cancers. Usually, the gene is amplified, resulting in receptor overexpression, massively…”
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Unexpected dynamics in femtomolar complexes of binding proteins with peptides by Cucuzza, Stefano, Sitnik, Malgorzata, Jurt, Simon, Michel, Erich, Dai, Wenzhao, Müntener, Thomas, Ernst, Patrick, Häussinger, Daniel, Plückthun, Andreas, Zerbe, Oliver

“…Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from…”
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Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure by Yang, Liu, Deng, Jianxin, Ma, Wenxia, Qiao, Aijun, Xu, Shiyue, Yu, Yang, Boriboun, Chan, Kang, Xiang, Han, Dunzheng, Ernst, Patrick, Zhou, Lufang, Shi, Jiawei, Zhang, Eric, Li, Tao-Sheng, Qiu, Hongyu, Nakagawa, Shinichi, Blackshaw, Seth, Zhang, Jianyi, Qin, Gangjian

“…The conserved long non-coding RNA (lncRNA) myocardial infarction associate transcript ( ) was identified for its multiple single-nucleotide polymorphisms that…”
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Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization by Friedrich, Nikolas, Stiegeler, Emanuel, Glögl, Matthias, Lemmin, Thomas, Hansen, Simon, Kadelka, Claus, Wu, Yufan, Ernst, Patrick, Maliqi, Liridona, Foulkes, Caio, Morin, Mylène, Eroglu, Mustafa, Liechti, Thomas, Ivan, Branislav, Reinberg, Thomas, Schaefer, Jonas V., Karakus, Umut, Ursprung, Stephan, Mann, Axel, Rusert, Peter, Kouyos, Roger D., Robinson, John A., Günthard, Huldrych F., Plückthun, Andreas, Trkola, Alexandra

“…The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare…”
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Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity by Zhao, Meng, Tang, Yawen, Ernst, Patrick J, Kahn-Krell, Asher, Fan, Chengming, Pretorius, Danielle, Zhu, Hanxi, Lou, Xi, Zhou, Lufang, Zhang, Jianyi, Zhu, Wuqiang

“…A crucial factor in improving cellular therapy effectiveness for myocardial regeneration is to safely and efficiently increase the cell engraftment rate…”
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454 A Human 3D Model of Duchenne Muscular Dystrophy Cardiomyopathy to Investigate Calcium Regulation and Mitochondrial Dysfunction by Ernst, Patrick, Dora, Michaela, Zhou, Lufang, Ogle, Brenda, Kamdar, Forum

“…OBJECTIVES/GOALS: We will use control- and DMD-engineered heart tissues to better model and investigate DMD cardiomyopathy. We will primarily assess cardiac…”
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Cardiac calcium regulation in human induced pluripotent stem cell cardiomyocytes: Implications for disease modeling and maturation by Ernst, Patrick, Bidwell, Philip A, Dora, Michaela, Thomas, David D, Kamdar, Forum

“…Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are based on ground-breaking technology that has significantly impacted cardiovascular research…”
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Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition by Reichen, Christian, Hansen, Simon, Forzani, Cristina, Honegger, Annemarie, Fleishman, Sarel J., Zhou, Ting, Parmeggiani, Fabio, Ernst, Patrick, Madhurantakam, Chaithanya, Ewald, Christina, Mittl, Peer R.E., Zerbe, Oliver, Baker, David, Caflisch, Amedeo, Plückthun, Andreas

“…Armadillo repeat proteins (ArmRPs) recognize their target peptide in extended conformation and bind, in a first approximation, two residues per repeat. Thus,…”
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Antibody–Drug Conjugate to Treat Meningiomas by Chen, Kai, Si, Yingnan, Ou, Jianfa, Guan, Jia-Shiung, Kim, Seulhee, Ernst, Patrick, Zhang, Ya, Zhou, Lufang, Han, Xiaosi, Liu, Xiaoguang (Margaret)

“…Meningiomas are primary tumors of the central nervous system with high recurrence. It has been reported that somatostatin receptor 2 (SSTR2) is highly…”
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Lessons learned from implementing alternative rites in the fight against female genital mutilation/cutting by Graamans, Ernst Patrick, Zolnikov, Tara Rava, Smet, Eefje, Nguura, Peter Ngatia, Leshore, Lepantas Charles, Have, Steven Ten

“…historically, programs aimed at making communities abolish female genital mutilation or cutting (FGM/C) consisted mainly of awareness campaigns on sexual…”
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Mitochondrial-Mediated Oxidative Ca2+/Calmodulin-Dependent Kinase II Activation Induces Early Afterdepolarizations in Guinea Pig Cardiomyocytes: An In Silico Study by Yang, Ruilin, Ernst, Patrick, Song, Jiajia, Liu, Xiaoguang M, Huke, Sabine, Wang, Shuxin, Zhang, Jianyi Jay, Zhou, Lufang

“…Background Oxidative stress–mediated Ca2+/calmodulin‐dependent protein kinase II (CaMKII) phosphorylation of cardiac ion channels has emerged as a critical…”
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Legislation against girl circumcision: a cultural psychological understanding of prohibition by Graamans, Ernst Patrick, Smet, Eefje, ten Have, Steven

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KnowLife: a versatile approach for constructing a large knowledge graph for biomedical sciences by Ernst, Patrick, Siu, Amy, Weikum, Gerhard

“…Biomedical knowledge bases (KB's) have become important assets in life sciences. Prior work on KB construction has three major limitations. First, most…”
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The Blurry Line Between Corporation and Cult: A Retrospective Autoethnographic Study by Graamans, Ernst Patrick

“…In popular management literature corporations are sometimes loosely compared to cults. The comparison is a severe allegation as it implies the transgression of…”
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