Search Results - "Ernesto Carafoli"

Calcium Pumps in Health and Disease by Brini, Marisa, Carafoli, Ernesto

“…Departments of Biochemistry and Experimental Veterinary Sciences, University of Padova, and Venetian Institute of Molecular Medicine, Padova, Italy Ca 2+…”
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Calcium Signaling: A Tale for All Seasons by Carafoli, Ernesto

“…An experiment performed in London nearly 120 years ago, which by today's standards would be considered unacceptably sloppy, marked the beginning of the calcium…”
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Is hydroxychloroquine beneficial for COVID-19 patients? by Li, Xing, Wang, Ying, Agostinis, Patrizia, Rabson, Arnold, Melino, Gerry, Carafoli, Ernesto, Shi, Yufang, Sun, Erwei

“…The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019…”
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plasma membrane calcium pump in health and disease by Brini, Marisa, Calì, Tito, Ottolini, Denis, Carafoli, Ernesto

“…The Ca²⁺ ATPases of the plasma membrane (PMCA pumps) export Ca²⁺ from all eukaryotic cells. In mammals they are the products of four separate genes. PMCA types…”
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BCG vaccination policy and preventive chloroquine usage: do they have an impact on COVID-19 pandemic? by Sharma, Abhibhav, Kumar Sharma, Saurabh, Shi, Yufang, Bucci, Enrico, Carafoli, Ernesto, Melino, Gerry, Bhattacherjee, Arnab, Das, Gobardhan

“…Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2). In the light of its rapid global spreading, on…”
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The plasma membrane Ca2+ ATPase of animal cells: structure, function and regulation by Di Leva, Francesca, Domi, Teuta, Fedrizzi, Laura, Lim, Dmitry, Carafoli, Ernesto

“…Most important processes in cell life are regulated by calcium (Ca2+). A number of mechanisms have thus been developed to maintain the concentration of free…”
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Calcium Homeostasis and Mitochondrial Dysfunction in Striatal Neurons of Huntington Disease by Lim, Dmitry, Fedrizzi, Laura, Tartari, Marzia, Zuccato, Chiara, Cattaneo, Elena, Brini, Marisa, Carafoli, Ernesto

“…Dysfunctions of Ca2+ homeostasis and of mitochondria have been studied in immortalized striatal cells from a commonly used Huntington disease mouse model…”
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Historical review: Mitochondria and calcium: ups and downs of an unusual relationship by Carafoli, Ernesto

“…The discovery of Ca 2+ transport by mitochondria is conventionally credited to De Luca and Engstrom, and Vasington and Murphy, who showed in 1961–1962 that Ca…”
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Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli by Costa, Veronica, Giacomello, Marta, Hudec, Roman, Lopreiato, Raffaele, Ermak, Gennady, Lim, Dmitri, Malorni, Walter, Davies, Kelvin J. A., Carafoli, Ernesto, Scorrano, Luca

“…Huntington's disease (HD), a genetic neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) protein, is accompanied by multiple…”
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Mutation of plasma membrane Ca²⁺ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca²⁺ homeostasis by Zanni, Ginevra, Calì, Tito, Kalscheuer, Vera M, Ottolini, Denis, Barresi, Sabina, Lebrun, Nicolas, Montecchi-Palazzi, Luisa, Hu, Hao, Chelly, Jamel, Bertini, Enrico, Brini, Marisa, Carafoli, Ernesto

“…Ca ²⁺ in neurons is vital to processes such as neurotransmission, neurotoxicity, synaptic development, and gene expression. Disruption of Ca ²⁺ homeostasis…”
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Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity by Bano, Daniele, Young, Kenneth W, Guerin, Christopher J, Lefeuvre, Ros, Rothwell, Nancy J, Naldini, Luigi, Rizzuto, Rosario, Carafoli, Ernesto, Nicotera, Pierluigi

“…In brain ischemia, gating of postsynaptic glutamate receptors and other membrane channels triggers intracellular Ca2+ overload and cell death. In excitotoxic…”
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A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia by Vicario, Mattia, Zanni, Ginevra, Vallese, Francesca, Santorelli, Filippo, Grinzato, Alessandro, Cieri, Domenico, Berto, Paola, Frizzarin, Martina, Lopreiato, Raffaele, Zonta, Francesco, Ferro, Stefania, Sandre, Michele, Marin, Oriano, Ruzzene, Maria, Bertini, Enrico, Zanotti, Giuseppe, Brini, Marisa, Calì, Tito, Carafoli, Ernesto

“…The fine regulation of intracellular calcium is fundamental for all eukaryotic cells. In neurons, Ca2+ oscillations govern the synaptic development, the…”
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The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity by Vallese, Francesca, Maso, Lorenzo, Giamogante, Flavia, Poggio, Elena, Barazzuol, Lucia, Salmaso, Andrea, Lopreiato, Raffaele, Cendron, Laura, Navazio, Lorella, Zanni, Ginevra, Weber, Yvonne, Kovacevic-Preradovic, Tatjana, Keren, Boris, Torraco, Alessandra, Carrozzo, Rosalba, Peretto, Francesco, Peggion, Caterina, Ferro, Stefania, Marin, Oriano, Zanotti, Giuseppe, Calì, Tito, Brini, Marisa, Carafoli, Ernesto

“…Calcium concentration must be finely tuned in all eukaryotic cells to ensure the correct performance of its signalling function. Neuronal activity is…”
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Calpain: A Protease in Search of a Function? by Carafoli, Ernesto, Molinari, Maurizio

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Why Calcium? How Calcium Became the Best Communicator by Carafoli, Ernesto, Krebs, Joachim

“…Calcium carries messages to virtually all important functions of cells. Although it was already active in unicellular organisms, its role became universally…”
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Generation, control, and processing of cellular calcium signals by Carafoli, E, Santella, L, Branca, D, Brini, M

“…In the course of evolution, Ca2+ has emerged as the most versatile intracellular messenger. Its concentration within cells is controlled by reversible binding…”
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The role of phosphorylation on the structure and dynamics of phospholamban: A model from molecular simulations by Pantano, Sergio, Carafoli, Ernesto

“…Phospholamban (PLB) is a small membrane protein that regulates the activity of the calcium ATP‐ase in the cardiac, slow‐twitch, and smooth muscle sarcoplasmic…”
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Crystal structure of sarcoplasmic reticulum Ca2+-ATPase (SERCA) from bovine muscle by Sacchetto, Roberta, Bertipaglia, Ilenia, Giannetti, Sara, Cendron, Laura, Mascarello, Francesco, Damiani, Ernesto, Carafoli, Ernesto, Zanotti, Giuseppe

“…The SERCA pump, a membrane protein of about 110kDa, transports two Ca2+ ions per ATP hydrolyzed from the cytoplasm to the lumen of the sarcoplasmic reticulum…”
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Chloroquine and hydroxychloroquine in the prophylaxis and therapy of COVID-19 infection by Carafoli, Ernesto

“…At the end of last century a prominent biochemist once opened the discussion of a controversial issue in the field of Bioenergetics with the following…”
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Interplay of the Ca2+-binding Protein DREAM with Presenilin in Neuronal Ca2+ Signaling by Fedrizzi, Laura, Lim, Dmitry, Carafoli, Ernesto, Brini, Marisa

“…The Ca2+-binding protein DREAM regulates gene transcription and Kv potassium channels in neurons but has also been claimed to interact with presenilins, which…”
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