Rubella seroprevalence among pregnant women in Burkina Faso

Rubella seroprevalence among pregnant women in Burkina Faso

Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso. Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urb...

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Published in:BMC infectious diseases Vol. 13; no. 1; p. 164
Main Authors: Tahita, Marc C, Hübschen, Judith M, Tarnagda, Zekiba, Ernest, Da, Charpentier, Emilie, Kremer, Jacques R, Muller, Claude P, Ouedraogo, Jean B
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 04-04-2013
BioMed Central
Subjects:
Adolescent
Adult
Age
Antibodies, Viral - blood
Burkina Faso - epidemiology
Confidence intervals
Enzyme-Linked Immunosorbent Assay
Female
Health facilities
Humans
Immunoglobulin G - blood
Infections
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Rubella
Rubella - epidemiology
Rubella virus
Rubella virus - immunology
Rural areas
Seroepidemiologic Studies
Urban areas
Vaccines
Womens health
Young Adult
Burkina Faso
Luxembourg
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Summary:Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso. Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Houndé (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit. An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341). The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.
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ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-13-164