Search Results - "Erlandsson, Malin"
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Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis
Published in Proceedings of the National Academy of Sciences - PNAS (18-12-2018)“…Rheumatoid arthritis (RA) is an inflammatory joint disease with a neurological component including depression, cognitive deficits, and pain, which…”
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Bone remodelling: locus minori or unappreciated potential of tofacitinib?
Published in Rheumatology (Oxford, England) (01-08-2018)“…This editorial refers to the article "Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model" by Bruno Vidal et…”
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Ex Vivo Vascular Imaging and Perfusion Studies of Normal Kidney and Tumor Vasculature
Published in Cancers (20-05-2024)“…This work describes a comprehensive study of the vascular tree and perfusion characteristics of normal kidney and renal cell carcinoma. Methods: Nephrectomy…”
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Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent Cohorts
Published in Cancers (04-05-2021)“…Breast cancer (BC) histological and molecular classifications significantly improved the treatment strategy and prognosis. Inhibitor of apoptosis…”
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IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis
Published in Biochimica et biophysica acta. Bioenergetics (01-09-2017)“…Signalling through insulin-like growth factor 1 receptor (IGF-1R) is essential for cell survival, but may turn pathogenic in uncontrolled tissue growth in…”
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Radiological features of experimental staphylococcal septic arthritis by micro computed tomography scan
Published in PloS one (02-02-2017)“…Permanent joint dysfunction due to bone destruction occurs in up to 50% of patients with septic arthritis. Recently, imaging technologies such as micro…”
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Metabolic signature and proteasome activity controls synovial migration of CDC42hiCD14+ cells in rheumatoid arthritis
Published in Frontiers in immunology (2023)“…Objective Activation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint…”
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Chronic hyperinsulinemia promotes human hepatocyte senescence
Published in Molecular metabolism (Germany) (01-10-2022)“…Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells…”
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IGF1R signalling is a guardian of self-tolerance restricting autoantibody production
Published in Frontiers in immunology (29-08-2022)“…Objective Insulin-like growth factor 1 receptor (IGF1R) acts at the crossroad between immunity and cancer, being an attractive therapeutic target in these…”
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Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis
Published in BMC medicine (22-07-2019)“…Since low insulin-like growth factor (IGF) 1 is often linked to inflammation, we analyze whether serum levels of IGF1 are associated with cardiovascular…”
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MicroRNA and interleukin 6 interplay in the adipose tissue of rheumatoid arthritis patients
Published in Clinical and experimental rheumatology (01-01-2023)“…MicroRNAs (miRs) are non-translated RNA sequences that elicit negative control over protein expression. The adipose tissue (AT) is considered the major…”
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Survivin improves the early recognition of rheumatoid arthritis among patients with arthralgia: A population-based study within two university cities of Sweden
Published in Seminars in arthritis and rheumatism (01-06-2018)“…The aim of this study was to validate the use of survivin for preclinical recognition of rheumatoid arthritis (RA) among patients with unexplained arthralgia…”
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Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8 + T Cells in Rheumatoid Arthritis
Published in Frontiers in immunology (14-07-2020)“…Smoking suppresses PD-1 expression in patients with rheumatoid arthritis (RA). In this study, we assess if smoking changed the epigenetic control over CD8 T…”
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Cohesin-Mediated Chromatin Interactions and Autoimmunity
Published in Frontiers in immunology (10-02-2022)“…Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions…”
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Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes arthritis
Published in Journal of autoimmunity (01-06-2022)“…Conditional mutation of protein geranylgeranyltransferase type I (GGTase-I) in macrophages (GLC) activates Rho-GTPases and causes arthritis in mice. Knocking…”
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Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis
Published in Rheumatology (Oxford, England) (01-11-2018)“…Abstract Objective Macrophage inflammatory protein 1-alpha (CCL3) is a chemokine that regulates macrophage trafficking to the inflamed joint. The agonistic…”
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Immunomodulation by the estrogen metabolite 2-methoxyestradiol
Published in Clinical immunology (Orlando, Fla.) (01-07-2014)“…Abstract 2-methoxyestradiol (2me2), a metabolite of 17β-estradiol (E2), has been tested in phase II clinical cancer trials and models of inflammation. Its…”
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Published in Nature communications (04-09-2019)“…Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However,…”
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Effects of implant‐delivered insulin on bone formation in osteoporotic rats
Published in Journal of biomedical materials research. Part A (01-09-2018)“…Osteoporosis is a major cause of age‐related fractures. Healing complications in osteoporotic patients are often associated with increased mortality and…”
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High Expression of STAT3 in Subcutaneous Adipose Tissue Associates with Cardiovascular Risk in Women with Rheumatoid Arthritis
Published in International journal of molecular sciences (13-11-2017)“…Despite the predominance of female patients and uncommon obesity, rheumatoid arthritis (RA) is tightly connected to increased cardiovascular morbidity. The aim…”
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