Search Results - "Erlacher, Miriam"

THE NEW KID ON THE BLOCK: UBTF-TD by Erlacher, Miriam

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SH2B3 alterations in a novel genetic condition, juvenile myelomonocytic leukemia, and myeloproliferative neoplasia by Niemeyer, Charlotte M, Erlacher, Miriam

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The role of inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models? by Wang, Jun, Erlacher, Miriam, Fernandez-Orth, Juncal

“…Hematopoiesis is a remarkable system that plays an important role in not only immune cell function, but also in nutrient transport, hemostasis and wound…”
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The different faces of GATA2 deficiency: implications for therapy and surveillance by Vinci, Luca, Strahm, Brigitte, Speckmann, Carsten, Erlacher, Miriam

“…GATA2 deficiency is one of the most common genetic predispositions to pediatric myelodysplastic syndrome (MDS) in children and adolescents. The wide spectrum…”
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Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans by Buonocore, Federica, Kühnen, Peter, Suntharalingham, Jenifer P, Del Valle, Ignacio, Digweed, Martin, Stachelscheid, Harald, Khajavi, Noushafarin, Didi, Mohammed, Brady, Angela F, Blankenstein, Oliver, Procter, Annie M, Dimitri, Paul, Wales, Jerry K H, Ghirri, Paolo, Knöbl, Dieter, Strahm, Brigitte, Erlacher, Miriam, Wlodarski, Marcin W, Chen, Wei, Kokai, George K, Anderson, Glenn, Morrogh, Deborah, Moulding, Dale A, McKee, Shane A, Niemeyer, Charlotte M, Grüters, Annette, Achermann, John C

“…It is well established that somatic genomic changes can influence phenotypes in cancer, but the role of adaptive changes in developmental disorders is less…”
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Lentivirus-Mediated BCL-XL Overexpression Inhibits Stem Cell Apoptosis during Ex Vivo Expansion and Provides Competitive Advantage Following Xenotransplantation by Zehnle, Patricia M. A., Wu, Ying, Koleci, Naile, Bohler, Sheila, Erlacher, Miriam

“…Hematopoietic reconstitution after hematopoietic stem cell transplantation (HSCT) is influenced by the number of transplanted cells. However, under certain…”
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Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7 by Pastor, Victor B, Sahoo, Sushree S, Boklan, Jessica, Schwabe, Georg C, Saribeyoglu, Ebru, Strahm, Brigitte, Lebrecht, Dirk, Voss, Matthias, Bryceson, Yenan T, Erlacher, Miriam, Ehninger, Gerhard, Niewisch, Marena, Schlegelberger, Brigitte, Baumann, Irith, Achermann, John C, Shimamura, Akiko, Hochrein, Jochen, Tedgård, Ulf, Nilsson, Lars, Hasle, Henrik, Boerries, Melanie, Busch, Hauke, Niemeyer, Charlotte M, Wlodarski, Marcin W

“…Familial myelodysplastic syndromes arise from haploinsufficiency of genes involved in hematopoiesis and are primarily associated with early-onset disease. Here…”
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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal by You, Han, Pellegrini, Marc, Tsuchihara, Katsuya, Yamamoto, Kazuo, Hacker, Georg, Erlacher, Miriam, Villunger, Andreas, Mak, Tak W

“…Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner…”
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Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis by Bohler, Sheila, Afreen, Sehar, Fernandez-Orth, Juncal, Demmerath, Eva-Maria, Molnar, Christian, Wu, Ying, Weiss, Julia Miriam, Mittapalli, Venugopal Rao, Konstantinidis, Lukas, Schmal, Hagen, Kunze, Mirjam, Erlacher, Miriam

“…BH3-mimetics inhibiting anti-apoptotic BCL-2 proteins represent a novel and promising class of antitumor drugs. While the BCL-2 inhibitor venetoclax is already…”
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RELAPSED UBTF-TD MDS TREATED WITH VENETOCLAX AND AZACITIDINE by Hasle, Henrik, Ifversen, Marianne, Harder, Katja, Erlacher, Miriam

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Impact of tofacitinib treatment on human B-cells in vitro and in vivo by Rizzi, Marta, Lorenzetti, Raquel, Fischer, Kathleen, Staniek, Julian, Janowska, Iga, Troilo, Arianna, Strohmeier, Valentina, Erlacher, Miriam, Kunze, Mirjam, Bannert, Bettina, Kyburz, Diego, Voll, Reinhard E, Venhoff, Nils, Thiel, Jens

“…Abstract B-cells are pivotal to the pathogenesis of rheumatoid arthritis and tofacitinib, a JAK inhibitor, is effective and safe in its treatment. Tofacitinib…”
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In vitro and in vivo evaluation of possible pro-survival activities of PGE2, EGF, TPO and FLT3L on human hematopoiesis by Demmerath, Eva-Maria, Bohler, Sheila, Kunze, Mirjam, Erlacher, Miriam

“…Myelosuppression is a major and frequently dose-limiting side effect of anticancer therapy and is responsible for most treatment-related morbidity and…”
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A novel classification of hematologic conditions in patients with Fanconi anemia by Behrens, Yvonne Lisa, Göhring, Gudrun, Bawadi, Randa, Cöktü, Sümeyye, Reimer, Christina, Hoffmann, Beatrice, Sänger, Birte, Käfer, Simon, Thol, Felicitas, Erlacher, Miriam, Niemeyer, Charlotte M, Baumann, Irith, Kalb, Reinhard, Schindler, Detlev, Kratz, Christian Peter

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Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation by Labi, Verena, Erlacher, Miriam, Krumschnabel, Gerhard, Manzl, Claudia, Tzankov, Alexandar, Pinon, Josephina, Egle, Alexander, Villunger, Andreas

“…Apoptosis triggered by p53 upon DNA damage secures removal of cells with compromised genomes, and is thought to prevent tumorigenesis. In contrast, we provide…”
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Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf by Labi, Verena, Woess, Claudia, Tuzlak, Selma, Erlacher, Miriam, Bouillet, Philippe, Strasser, Andreas, Tzankov, Alexandar, Villunger, Andreas

“…BH3 domain-only proteins (BH3-only) proteins are members of the Bcl-2 family that play crucial roles in embryogenesis and the maintenance of tissue homeostasis…”
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Spontaneous remission and loss of monosomy 7: a window of opportunity for young children with SAMD9L syndrome by Erlacher, Miriam, Andresen, Felicia, Sukova, Martina, Stary, Jan, De Moerloose, Barbara, Bosch, Jutte van der Werff Ten, Dworzak, Michael, Seidel, Markus G, Polychronopoulou, Sophia, Beier, Rita, Kratz, Christian P, Nathrath, Michaela, Frühwald, Michael C, Göhring, Gudrun, Bergmann, Anke K, Mayerhofer, Christina, Lebrecht, Dirk, Ramamoorthy, Senthilkumar, Yoshimi, Ayami, Strahm, Brigitte, Wlodarski, Marcin W, Niemeyer, Charlotte M

“…Monosomy 7 is the most common cytogenetic abnormality in pediatric myelodysplastic syndrome (MDS) and associated with a high risk of disease progression…”
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Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation by Abdulhay, Nour J, Fiorini, Claudia, Verboon, Jeffrey M, Ludwig, Leif S, Ulirsch, Jacob C, Zieger, Barbara, Lareau, Caleb A, Mi, Xiaoli, Roy, Anindita, Obeng, Esther A, Erlacher, Miriam, Gupta, Namrata, Gabriel, Stacey B, Ebert, Benjamin L, Niemeyer, Charlotte M, Khoriaty, Rami N, Ancliff, Philip, Gazda, Hanna T, Wlodarski, Marcin W, Sankaran, Vijay G

“…Studies of allelic variation underlying genetic blood disorders have provided important insights into human hematopoiesis. Most often, the identified…”
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Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia by Hofmans, Mattias, Lammens, Tim, Depreter, Barbara, Wu, Ying, Erlacher, Miriam, Caye, Aurélie, Cavé, Hélène, Flotho, Christian, de Haas, Valerie, Niemeyer, Charlotte M., Stary, Jan, Van Nieuwerburgh, Filip, Deforce, Dieter, Van Loocke, Wouter, Van Vlierberghe, Pieter, Philippé, Jan, De Moerloose, Barbara

“…Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of…”
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P1000: JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) INHIBITS T CELL PROLIFERATION VIA THE ECTONUCLEOTIDASE CD39 AND THE PURINERGIC NETWORK by Rajak, Jovana, Koleci, Naile, Mesesan, Andreea, Flotho, Christian, Niemeyer, Charlotte, Bengsch, Bertram, Erlacher, Miriam

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Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood by Michler, Pia, Schedel, Anne, Witschas, Martha, Friedrich, Ulrike Anne, Wagener, Rabea, Mehtonen, Juha, Brozou, Triantafyllia, Menzel, Maria, Walter, Carolin, Nabi, Dalileh, Pearce, Glen, Erlacher, Miriam, Göhring, Gudrun, Dugas, Martin, Heinäniemi, Merja, Borkhardt, Arndt, Stölzel, Friedrich, Hauer, Julia, Auer, Franziska

“…While the shelterin complex guards and coordinates the mechanism of telomere regulation, deregulation of this process is tightly linked to malignant…”
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