Search Results - "Erkut, Cihan"

The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast by Erkut, Cihan, Gade, Vamshidhar R, Laxman, Sunil, Kurzchalia, Teymuras V

“…Many organisms, including species from all kingdoms of life, can survive desiccation by entering a state with no detectable metabolism. To survive, C. elegans…”
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Transcriptome profiling for precision cancer medicine using shallow nanopore cDNA sequencing by Mock, Andreas, Braun, Melissa, Scholl, Claudia, Fröhling, Stefan, Erkut, Cihan

“…Transcriptome profiling is a mainstay of translational cancer research and is increasingly finding its way into precision oncology. While bulk RNA sequencing…”
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Molecular strategies of the Caenorhabditis elegans dauer larva to survive extreme desiccation by Erkut, Cihan, Vasilj, Andrej, Boland, Sebastian, Habermann, Bianca, Shevchenko, Andrej, Kurzchalia, Teymuras V

“…Massive water loss is a serious challenge for terrestrial animals, which usually has fatal consequences. However, some organisms have developed means to…”
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Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung by Martins, Leila R., Sieverling, Lina, Michelhans, Michelle, Schiller, Chiara, Erkut, Cihan, Grünewald, Thomas G. P., Triana, Sergio, Fröhling, Stefan, Velten, Lars, Glimm, Hanno, Scholl, Claudia

“…Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung…”
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A metabolic switch regulates the transition between growth and diapause in C. elegans by Penkov, Sider, Raghuraman, Bharath Kumar, Erkut, Cihan, Oertel, Jana, Galli, Roberta, Ackerman, Eduardo Jacobo Miranda, Vorkel, Daniela, Verbavatz, Jean-Marc, Koch, Edmund, Fahmy, Karim, Shevchenko, Andrej, Kurzchalia, Teymuras V

“…Metabolic activity alternates between high and low states during different stages of an organism's life cycle. During the transition from growth to quiescence,…”
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Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma by Berthold, Ruth, Isfort, Ilka, Erkut, Cihan, Heinst, Lorena, Grünewald, Inga, Wardelmann, Eva, Kindler, Thomas, Åman, Pierre, Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Trautmann, Marcel, Fröhling, Stefan, Scholl, Claudia, Hartmann, Wolfgang

“…Myxoid liposarcoma (MLS) represents a common subtype of liposarcoma molecularly characterized by a recurrent chromosomal translocation that generates a…”
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Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans by Penkov, Sider, Kaptan, Damla, Erkut, Cihan, Sarov, Mihail, Mende, Fanny, Kurzchalia, Teymuras V.

“…Under adverse conditions, Caenorhabditis elegans enters a diapause stage called the dauer larva. External cues signal the nuclear hormone receptor DAF-12, the…”
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Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival by Toyoda, Yusuke, Erkut, Cihan, Pan-Montojo, Francisco, Boland, Sebastian, Stewart, Martin P, Müller, Daniel J, Wurst, Wolfgang, Hyman, Anthony A, Kurzchalia, Teymuras V

“…Parkinson's disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra. One of the genes linked with the onset of…”
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How worms survive desiccation: Trehalose pro water by Erkut, Cihan, Penkov, Sider, Fahmy, Karim, Kurzchalia, Teymuras V.

“…While life requires water, many organisms, known as anhydrobiotes, can survive in the absence of water for extended periods of time. Although discovered 300…”
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The C. elegans dauer larva as a paradigm to study metabolic suppression and desiccation tolerance by Erkut, Cihan, Kurzchalia, Teymuras V.

“…Main conclusion The hypometabolic, stress-resistant dauer larva of Caenorhabditis elegans serves as an excellent model to study the molecular mechanisms of…”
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Trehalose Renders the Dauer Larva of Caenorhabditis elegans Resistant to Extreme Desiccation by Erkut, Cihan, Penkov, Sider, Khesbak, Hassan, Vorkel, Daniela, Verbavatz, Jean-Marc, Fahmy, Karim, Kurzchalia, Teymuras V.

“…Water is essential for life on Earth. In its absence, however, some organisms can interrupt their life cycle and temporarily enter an ametabolic state, known…”
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The Role of Phospholipid Headgroup Composition and Trehalose in the Desiccation Tolerance of Caenorhabditis elegans by Abusharkh, Sawsan E, Erkut, Cihan, Oertel, Jana, Kurzchalia, Teymuras V, Fahmy, Karim

“…Anhydrobiotic organisms have the remarkable ability to lose extensive amounts of body water and survive in an ametabolic state. Distributed to various taxa of…”
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Hydration and Temperature-Induced Phospholipid Phase Transitions and their Influence on Desiccation Tolerance of the Nematode Caenorhabditis Elegans by Abusharkh, Sawsan E., Erkut, Cihan, Kurzchalia, Teymuras, Fahmy, Karim

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Receptor-Tyrosine Kinase Inhibitor Ponatinib Inhibits Meningioma Growth In Vitro and In Vivo by Yu, Tao, Cao, Junguo, Alaa Eddine, Montadar, Moustafa, Mahmoud, Mock, Andreas, Erkut, Cihan, Abdollahi, Amir, Warta, Rolf, Unterberg, Andreas, Herold-Mende, Christel, Jungwirth, Gerhard

“…To date, there is no standard-of-care systemic therapy for the treatment of aggressive meningiomas. Receptor tyrosine kinases (RTK) are frequently expressed in…”
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The role of phospholipid headgroup composition and trehalose in the desiccation tolerance of Caenorhabditis elegans by Abusharkh, Sawsan E., Erkut, Cihan, Oertel, Jana, Kurzchalia, Teymuras V., Fahmy, Karim

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Abstract PR004: Fusion protein-driven IGF-IR signals deregulate hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 by Berthold, Ruth, Isfort, Ilka, Erkut, Cihan, Heinst, Lorena, Grünewald, Inga, Wardelmann, Eva, Kindler, Thomas, Åman, Pierre, Grünewald, Thomas G.P., Cidre-Aranaz, Florencia, Trautmann, Marcel, Fröhling, Stefan, Scholl, Claudia, Hartmann, Wolfgang

“…Abstract Introduction: Myxoid liposarcoma (MLS) is molecularly characterized by a recurrent chromosomal translocation which generates a chimeric FUS-DDIT3…”
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Maradolipids: Diacyltrehalose Glycolipids Specific to Dauer Larva in Caenorhabditis elegans by Penkov, Sider, Mende, Fanny, Zagoriy, Vyacheslav, Erkut, Cihan, Martin, René, Pässler, Ulrike, Schuhmann, Kai, Schwudke, Dominik, Gruner, Margit, Mäntler, Jana, Reichert-Müller, Thomas, Shevchenko, Andrej, Knölker, Hans-Joachim, Kurzchalia, Teymuras V

“…Don't stress: Maradolipids (see picture; red O, grey C, white H) are the first diacyltrehaloses found to be produced in animal organisms. The nematode…”
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How worms survive desiccation: Trehalose by Erkut, Cihan, Penkov, Sider, Fahmy, Karim, Kurzchalia, Teymuras V.

“…While life requires water, many organisms, known as anhydrobiotes, can survive in the absence of water for extended periods of time. Although discovered 300…”
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Maradolipids: Diacyltrehalose Glycolipids Specific to Dauer Larva in Caenorhabditis elegans by Penkov, Sider, Mende, Fanny, Zagoriy, Vyacheslav, Erkut, Cihan, Martin, René, Pässler, Ulrike, Schuhmann, Kai, Schwudke, Dominik, Gruner, Margit, Mäntler, Jana, Reichert-Müller, Thomas, Shevchenko, Andrej, Knölker, Hans-Joachim, Kurzchalia, Teymuras V.

“…Kein Stress: Maradolipide (siehe Bild; O rot, C grau, H weiß) sind die ersten Diacyltrehalosen, deren Produktion in tierischen Organismen nachgewiesen wurde…”
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Maradolipids: Diacyltrehalose Glycolipids Specific to Dauer Larva in Caenorhabditis elegans by Penkov, Sider, Mende, Fanny, Zagoriy, Vyacheslav, Erkut, Cihan, Martin, René, Pässler, Ulrike, Schuhmann, Kai, Schwudke, Dominik, Gruner, Margit, Mäntler, Jana, Reichert‐Müller, Thomas, Shevchenko, Andrej, Knölker, Hans‐Joachim, Kurzchalia, Teymuras V.

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