Search Results - "Erker, Laura R"

Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood–Onset Retinal Dystrophy by Weleber, Richard G., MD, Pennesi, Mark E., MD, PhD, Wilson, David J., MD, Kaushal, Shalesh, MD, PhD, Erker, Laura R., PhD, Jensen, Lauren, MS, RN, McBride, Maureen T., BS, Flotte, Terence R., MD, Humphries, Margaret, RN, Calcedo, Roberto, PhD, Hauswirth, William W., PhD, Chulay, Jeffrey D., MD, Stout, J. Timothy, MD, PhD

“…Purpose To provide an initial assessment of the safety of a recombinant adeno-associated virus vector expressing RPE65 (rAAV2-CB-hRPE65) in adults and children…”
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Assessment of Different Sampling Methods for Measuring and Representing Macular Cone Density Using Flood-Illuminated Adaptive Optics by Feng, Shu, Gale, Michael J, Fay, Jonathan D, Faridi, Ambar, Titus, Hope E, Garg, Anupam K, Michaels, Keith V, Erker, Laura R, Peters, Dawn, Smith, Travis B, Pennesi, Mark E

“…To describe a standardized flood-illuminated adaptive optics (AO) imaging protocol suitable for the clinical setting and to assess sampling methods for…”
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Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia by Langlo, Christopher S, Patterson, Emily J, Higgins, Brian P, Summerfelt, Phyllis, Razeen, Moataz M, Erker, Laura R, Parker, Maria, Collison, Frederick T, Fishman, Gerald A, Kay, Christine N, Zhang, Jing, Weleber, Richard G, Yang, Paul, Wilson, David J, Pennesi, Mark E, Lam, Byron L, Chiang, John, Chulay, Jeffrey D, Dubra, Alfredo, Hauswirth, William W, Carroll, Joseph

“…Congenital achromatopsia (ACHM) is an autosomal recessive disorder in which cone function is absent or severely reduced. Gene therapy in animal models of ACHM…”
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Three‐Year Safety Results of SAR422459 (EIAV‐ABCA4) Gene Therapy in Patients With ABCA4‐Associated Stargardt Disease: An Open‐Label Dose‐Escalation Phase I/IIa Clinical Trial, Cohorts 1‐5 by Parker, Maria A., Erker, Laura R., Audo, Isabelle, Choi, Dongseok, Mohand-Said, Saddek, Sestakauskas, Kastytis, Benoit, Patrick, Appelqvist, Terence, Krahmer, Melissa, Ségaut-Prévost, Caroline, Lujan, Brandon J., Faridi, Ambar, Chegarnov, Elvira N., Steinkamp, Peter N., Ku, Cristy, da Palma, Mariana Matioli, Barale, Pierre-Olivier, Ayelo-Scheer, Sarah, Lauer, Andreas, Stout, Tim, Wilson, David J., Weleber, Richard G., Pennesi, Mark E., Sahel, José Alain, Yang, Paul

“…To report on the safety of the first 5 cohorts of a gene therapy trial using recombinant equine infectious anemia virus expressing ABCA4 (EIAV-ABCA4) in adults…”
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Long-term characterization of retinal degeneration in rd1 and rd10 mice using spectral domain optical coherence tomography by Pennesi, Mark E, Michaels, Keith V, Magee, Sienna S, Maricle, Anastasiya, Davin, Sean P, Garg, Anupam K, Gale, Michael J, Tu, Daniel C, Wen, Yuquan, Erker, Laura R, Francis, Peter J

“…We characterize the in vivo changes over time in the retinal structure of wild-type mice alongside two lines of mice deficient in the β-subunit of…”
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REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA by Langlo, Christopher S, Erker, Laura R, Parker, Maria, Patterson, Emily J, Higgins, Brian P, Summerfelt, Phyllis, Razeen, Moataz M, Collison, Frederick T, Fishman, Gerald A, Kay, Christine N, Zhang, Jing, Weleber, Richard G, Yang, Paul, Pennesi, Mark E, Lam, Byron L, Chulay, Jeffrey D, Dubra, Alfredo, Hauswirth, William W, Wilson, David J, Carroll, Joseph

“…Congenital achromatopsia is an autosomal recessive disease causing substantial reduction or complete absence of cone function. Although believed to be a…”
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Residual Foveal Cone Structure in CNGB3 -Associated Achromatopsia by Langlo, Christopher S., Patterson, Emily J., Higgins, Brian P., Summerfelt, Phyllis, Razeen, Moataz M., Erker, Laura R., Parker, Maria, Collison, Frederick T., Fishman, Gerald A., Kay, Christine N., Zhang, Jing, Weleber, Richard G., Yang, Paul, Wilson, David J., Pennesi, Mark E., Lam, Byron L., Chiang, John, Chulay, Jeffrey D., Dubra, Alfredo, Hauswirth, William W., Carroll, Joseph

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Test-Retest Variability of Functional and Structural Parameters in Patients with Stargardt Disease Participating in the SAR422459 Gene Therapy Trial by Parker, Maria A, Choi, Dongseok, Erker, Laura R, Pennesi, Mark E, Yang, Paul, Chegarnov, Elvira N, Steinkamp, Peter N, Schlechter, Catherine L, Dhaenens, Claire-Marie, Mohand-Said, Saddek, Audo, Isabelle, Sahel, Jose, Weleber, Richard G, Wilson, David J

“…The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of…”
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Reliability of Spectral-Domain OCT Ellipsoid Zone Area and Shape Measurements in Retinitis Pigmentosa by Smith, Travis B, Parker, Maria A, Steinkamp, Peter N, Romo, Albert, Erker, Laura R, Lujan, Brandon J, Smith, Ning

“…We investigate the ellipsoid zone (EZ) area and EZ boundary shape measurement reliability and the operability characteristics of two methods of EZ boundary…”
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Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain-Optical Coherence Tomography by Hariri, Amir H, Zhang, Hong Yang, Ho, Alexander, Francis, Peter, Weleber, Richard G, Birch, David G, Ferris, 3rd, Frederick L, Sadda, SriniVas R

“…New methods are needed to quantify the change in the outer retinal structures in retinitis pigmentosa (RP). To implement an alternate method for tracking…”
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Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa by Smith, Travis B, Parker, Maria, Steinkamp, Peter N, Weleber, Richard G, Smith, Ning, Wilson, David J

“…To assess relationships between structural and functional biomarkers, including new topographic measures of visual field sensitivity, in patients with…”
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The relationship between oxidative stress, antioxidants and cancer by Erker, Laura R

“…Elevated levels of oxidative stress are found in cancerous tissues, there is evidence that ROS are involved in cellular signaling and that elevated levels of…”
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