Search Results - "Erickson, Scott A"

Methionine Aminopeptidase 2 Inhibition Is an Effective Treatment Strategy for Neuroblastoma in Preclinical Models by Morowitz, Michael J, Barr, Rosalind, Wang, Qun, King, Rebecca, Rhodin, Nicholas, Pawel, Bruce, Zhao, Huaqing, Erickson, Scott A, Sheppard, George S, Wang, Jieyi, Maris, John M, Shusterman, Suzanne

“…Tumor vascularity is correlated with an aggressive disease phenotype in neuroblastoma, suggesting that angiogenesis inhibitors may be a useful addition to…”
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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases by Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.

“…The design and enzyme activities of a novel class of imidazo[2,1- b]thiazoles is presented. The design and enzyme activities of a novel class of imidazo[2,1-…”
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Discovery and Optimization of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2:  A Structural Basis for the Reduction of Albumin Binding by Sheppard, George S, Wang, Jieyi, Kawai, Megumi, Fidanze, Steve D, BaMaung, Nwe Y, Erickson, Scott A, Barnes, David M, Tedrow, Jason S, Kolaczkowski, Lawrence, Vasudevan, Anil, Park, David C, Wang, Gary T, Sanders, William J, Mantei, Robert A, Palazzo, Fabio, Tucker-Garcia, Lora, Lou, Pingping, Zhang, Qian, Park, Chang H, Kim, Ki H, Petros, Andrew, Olejniczak, Edward, Nettesheim, David, Hajduk, Phillip, Henkin, Jack, Lesniewski, Richard, Davidsen, Steven K, Bell, Randy L

“…Methionine aminopeptidase-2 (MetAP2) is a novel target for cancer therapy. As part of an effort to discover orally active reversible inhibitors of MetAP2, a…”
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Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2 by JIEYI WANG, SHEPPARD, George S, FROST, David, TAPANG, Paul, ALBERT, Daniel H, MORGAN, Sherry J, MOROWITZ, Michael, SHUSTERMAN, Suzanne, MARIS, John M, LESNIEWSKI, Rick, HENKIN, Jack, PINGPING LOU, KAWAI, Megumi, BAMAUNG, Nwe, ERICKSON, Scott A, TUCKER-GARCIA, Lora, CHANG PARK, BOUSKA, Jennifer, WANG, Yi-Chun

“…Methionine aminopeptidase (MetAP)-2 has been suggested as a novel target for cancer therapy because the anticancer agent TNP-470 irreversibly inactivates the…”
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Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties by Kawai, Megumi, BaMaung, Nwe Y., Fidanze, Steve D., Erickson, Scott A., Tedrow, Jason S., Sanders, William J., Vasudevan, Anil, Park, Chang, Hutchins, Charles, Comess, Kenneth M., Kalvin, Douglas, Wang, Jieyi, Zhang, Qian, Lou, Pingping, Tucker-Garcia, Lora, Bouska, Jennifer, Bell, Randy L., Lesniewski, Richard, Henkin, Jack, Sheppard, George S.

“…Synthesis and biological activity of novel methionine aminopeptidase type -2 inhibitors having a sulfonamide bond are reported. We have screened molecules for…”
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Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases by HUBBARD, Robert D, BAMAUNG, Nwe Y, OSTERLING, Donald J, JOHNSON, Eric F, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, FIDANZE, Steve D, ERICKSON, Scott A, PALAZZO, Fabio, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora A, XIAOMING HU, KOVAR, Peter

“…Emerging clinical and pre-clinical data indicate that both insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor (EGF) family…”
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3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2 by SHEPPARD, George S, JIEYI WANG, PINGPING LOU, CHANG PARK, KIM, Ki H, HENKIN, Jack, LESNIEWSKI, Richard, KAWAI, Megumi, BAMAUNG, Nwe Y, CRAIG, Richard A, ERICKSON, Scott A, LYNCH, Linda, PATEL, Jyoti, FAN YANG, SEARLE, Xenia B

“…Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2)…”
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Effects of Lattice Segmentation on Microtubule Mechanics by Erickson, Scott A., Isozaki, Naoto, Ross, Jennifer, Hawkins, Taviare

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Preparation, X-ray Crystal Structure, and Chemistry of ((Arylsulfonyl)methyl)(phenyl)iodonium Triflates. Stable Alkyliodonium Salts by Zhdankin, Viktor V, Erickson, Scott A, Hanson, Kari J

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Abstract A245: Imidazo[2,1-b]thiazole and imidazo[1,2-a]pyridine amides as novel inhibitors of the insulin-like growth factor (IGF1R) and members of the epidermal growth factor family of tyrosine kinases by Fidanze, Steve D., Erickson, Scott A., Hubbard, Robert D., Wang, Gary T., Mantei, Robert A., BaMaung, Nwe Y., Clark, Richard F., Sorensen, Bryan K., Kovar, Peter, Pappano, William, Zhang, Qian, Wilsbacher, Julie L., Hu, Xiaoming, Tucker, Lora A., Cheng, Min, Swinger, Kerren K., Stewart, Kent D., Wang, Jieyi, Bell, Randy L., Davidsen, Steven K., Sheppard, George S.

“…Abstract The insulin-like growth factor 1 receptor (IGF1R) and its ligands, IGF1 and IGF2 are associated with cell growth and resistance to apoptosis. The ErbB…”
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Methionine aminopeptidase 2 inhibition is an effectivetreatment strategy for neuroblastoma in preclinical models by MOROWITZ, Michael J, BARR, Rosalind, MARIS, John M, SHUSTERMAN, Suzanne, QUN WANG, KING, Rebecca, RHODIN, Nicholas, PAWEL, Bruce, HUAQING ZHAO, ERICKSON, Scott A, SHEPPARD, George S, JIEYI WANG

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