Search Results - "Erickson, Richard R."

Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's by Buijsse, Brian, Lee, Duk-Hee, Steffen, Lyn, Erickson, Richard R, Luepker, Russell V, Jacobs, Jr, David R, Holtzman, Jordan L

“…Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high…”
Get full text

The Effect of Aging on the Chaperone Concentrations in the Hepatic, Endoplasmic Reticulum of Male Rats: The Possible Role of Protein Misfolding Due to the Loss of Chaperones in the Decline in Physiological Function Seen With Age by Erickson, Richard R., Dunning, Lisa M., Holtzman, Jordan L.

“…The endoplasmic reticulum (ER) chaperones are highly conserved proteins that catalyze the posttranslational processing of all secretory and membrane proteins…”
Get full text

In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind β-amyloid by Erickson, Richard R., Dunning, Lisa M., Olson, Douglas A., Cohen, Sheftel J., Davis, Alan T., Wood, W. Gibson, Kratzke, Robert A., Holtzman, Jordan L.

“…The β-amyloids (abetas) are the major components of the plaque observed in the brains of patients with Alzheimer’s disease. The conundrum is that although they…”
Get full text

Studies comparing the kinetics of cysteine conjugation and protein binding of acetaminophen by hepatic microsomes from male mice by Zhou, LingXiang, Erickson, Richard R, Holtzman, Jordan L

“…A large body of evidence indicates that acetaminophen toxicity is mediated through the formation of the reactive metabolite, N-acetyl- p-benzoquinone imine…”
Get full text

Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis by Thirman, M J, Albrecht, J H, Krueger, M A, Erickson, R R, Cherwitz, D L, Park, S S, Gelboin, H V, Holtzman, J L

“…Cigarette smoking is a leading risk factor for atherosclerosis. Endothelial injury may be the initial event in this process. The carcinogenic metabolites of…”
Get full text

The Covalent Binding of [14C]Acetaminophen to Mouse Hepatic Microsomal Proteins:  The Specific Binding to Calreticulin and the Two Forms of the Thiol:Protein Disulfide Oxidoreductases by Zhou, McKenzie, Bruce A, Eccleston, Eric D, Srivastava, Sri Prakash, Chen, Erickson, Richard R, Holtzman, Jordan Loyal

“…Numerous in vitro studies have indicated that acetaminophen is activated by mouse hepatic microsomal cytochrome P450 to form N-acetylbenzoquinone imine. This…”
Get full text

Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450 by Zhou, L, Erickson, R R, Hardwick, J P, Park, S S, Wrighton, S A, Holtzman, J L

“…We have previously found that for acetaminophen kinetic differences exist between the hepatic microsomal catalyzed protein binding and cysteine conjugation. We…”
Get more information

Role of substrate lipophilicity on the N-demethylation and type I binding of 3-O-alkylmorphine analogs by Duquette, Peter H, Erickson, Richard R, Holtzman, Jordan L

“…A series of 3-O-alkylmorphine analogues was synthesized to determine if there was a good correlation between the rate of metabolism, type I binding affinity,…”
Get full text

The Conversion of the Carcinogen N-Hydroxy-2-fluorenylacetamide to o-Amidophenols by Rat Liver in Vitro by Gutmann, Helmut R., Erickson, Richard R.

“…Previous work on the induced isomerization of the carcinogenic arylhydroxamic acid, N-hydroxy-2-fluorenylacetamide, to the o-amidophenols, 1-hydroxy- and…”
Get full text

Induction of Cytochrome CYPIA1 and Formation of Toxic Metabolities of Benzo[a]pyrene by Rat Aorta: A Possible Role in Atherogenesis by Thirman, Michael J., Albrecht, Jeffrey H., Krueger, Michele A., Erickson, Richard R., Cherwitz, David L., Park, Sang S., Gelboin, Harry V., Holtzman, Jordan L.

“…Cigarette smoking is a leading risk factor for atherosclerosis. Endothelial injury may be the initial event in this process. The carcinogenic metabolites of…”
Get full text

Sandbox Science: Simulating impact cratering by Fisher, David G., Erickson, Richard R., Hecht, Karen S.

Get full text

Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes by Crankshaw, D L, Erickson, R R, Holtzman, J L

Get more information

Studies on the effect of chronic consumption of moderate amounts of ethanol on male rat hepatic microsomal drug-metabolizing activity by Prasad, J S, Crankshaw, D L, Erickson, R R, Elliott, C E, Husby, A D, Holtzman, J L

“…Weanling, male Sprague-Dawley rats given 10% ethanol in the drinking water and food ad lib. for up to 8 weeks consumed 17% of their calories as ethanol. The…”
Get more information

Ethanol induction of acetaminophen toxicity and metabolism by Peterson, F J, Holloway, D E, Erickson, R R, Duquette, P H, McClain, C J, Holtzman, J L

Get more information

The effect of cytochrome P-450 and reduced glutathione on the ATP-dependent calcium pump of hepatic microsomes from male rats by Prasad, J S, Erickson, R R, Crankshaw, D L, Holtzman, J L

“…In the presence of ATP hepatic microsomes sequester calcium. This sequestration is thought to be important in the modulation of free cytosolic calcium…”
Get more information

Kinetic studies on the metabolism of ethylmorphine by isolated hepatocytes from adult rats by Erickson, R R, Holtzman, J L

Get more information

NEW FAINT VARIABLES NEAR THE NORTH GALACTIC POLE by Luyten, Willem J., Erickson, Richard R.

Get full text

Does cytochrome P-450 mediate the effects of norepinephrine in the hepatocyte? by Holtzman, J L, Prasad, J S, Erickson, R R, Chen, N Q, Liu, Y X, Srivastava, S P

Get more information

Spectrophotometric and radiometric studies on the in vivo binding of phenobarbital to hepatic microsomes by Holtzman, J L, Rumack, B H, Erickson, R R

Get more information

Methodological causes of discrepancies in radioimmunoassay for digoxin in human serum by Holtzman, J L, Shafer, R B, Erickson, R R

Get more information