Search Results - "Erickson, Leonard C"

Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells by Shen, Fei, Chu, Shaoyou, Bence, Aimee K, Bailey, Barbara, Xue, Xinjian, Erickson, Priscilla A, Montrose, Marshall H, Beck, William T, Erickson, Leonard C

“…P-glycoprotein (Pgp), a membrane transporter encoded by the MDR1 gene in human cells, mediates drug efflux from cells, and it plays a major role in causing…”
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Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells by Shen, Fei, Bailey, Barbara J, Chu, Shaoyou, Bence, Aimee K, Xue, Xinjian, Erickson, Priscilla, Safa, Ahmad R, Beck, William T, Erickson, Leonard C

“…P-glycoprotein (Pgp), a member of the ATP-binding cassette transporter family, is one of the major causes for multidrug resistance (MDR). We report using…”
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Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea by Zhang, Qiwei, Ohannesian, David W, Erickson, Leonard C

“…O(6)-Methylguanine DNA methyltransferase (MGMT) protects tumor cells from the cytotoxic effects of DNA-alkylating agents such as…”
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Synthesis and preliminary biological evaluation of O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy by WANG, Ji-Quan, KREKLAU, Emiko L, BAILEY, Barbara J, ERICKSON, Leonard C, ZHENG, Qi-Huang

“…A novel fluorine-18-labeled O6-benzylguanine (O6-BG) derivative, O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine (O6-[18F]FEMBG, [18F]1), has been synthesized…”
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Synthesis and preliminary biological evaluation of 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT by Liu, Xuan, Zheng, Qi-Huang, Fei, Xiangshu, Wang, Ji-Quan, Ohannesian, David W, Erickson, Leonard C, Stone, K.Lee, Hutchins, Gary D

“…Novel radiolabeled O 6-benzylguanine derivatives, 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines ([ 11C] p- O 6-MMBG, 1a; [ 11C] m- O 6-MMBG, 1b; ([ 11C] o- O…”
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Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity by HIROSE, Yuichi, KREKLAU, Emiko L, ERICKSON, Leonard C, BERGER, Mitchel S, PIEPER, Russell O

“…Temozolomide (TMZ)-induced O6-methylguanine (MG) DNA lesions, if not removed by MG-DNA methyltransferase (MGMT), mispair with thymine, trigger rounds of futile…”
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Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer by ZHENG, Qi-Huang, XUAN LIU, XIANGSHU FEI, WANG, Ji-Quan, OHANNESIAN, David W, ERICKSON, Leonard C, LEE STONE, K, HUTCHINS, Gary D

“…Novel radiolabeled O(6)-benzylguanine (O(6)-BG) derivatives, 2-amino-6-O-[(11)C]-[(methoxymethyl)benzyloxy]-9-methyl purines ([(11)C]p-O(6)-AMMP, 1a;…”
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Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea by Kreklau, Emiko L, Pollok, Karen E, Bailey, Barbara J, Liu, Naili, Hartwell, Jennifer R, Williams, David A, Erickson, Leonard C

“…The major mechanism of tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) is the DNA repair protein O(6)-methylguanine DNA methyltransferase…”
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In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations by Pollok, Karen E, Hartwell, Jennifer R, Braber, Annemarije, Cooper, Ryan J, Jansen, Michael, Ragg, Susanne, Bailey, Barbara J, Erickson, Leonard C, Kreklau, Emiko L, Williams, David A

“…Strategies that increase the ability of human hematopoietic stem and progenitor cells to repair alkylator-induced DNA damage may prevent the severe…”
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Fractionation of DNA from mammalian cells by alkaline elution by Kohn, Kurt W, Erickson, Leonard C, Ewig, Regina A. G, Friedman, Charles A

“…The method of alkaline elution provides a sensitive measure of DNA single-strand length distribution in mamalian cells and is applicable to a variety of…”
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Comparison of the effects of hydrogen peroxide and x-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79) by Bradley, M O, Erickson, L C

“…Hydrogen peroxide is not detectably mutagenic at the hypoxanthine-guanine phosphoribosyl transfer locus (measured as 6-thioguanine resistance) in V-79 Chinese…”
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A Convenient Procedure for the Synthesis of O6-Benzylguanine Derivatives by Phase Transfer Catalysis by Liu, Xuan, Zheng, Qi-Huang, Hutchins, Gary D., Fei, Xiangshu, Erickson, Leonard C., Miller, Kathy D., Mock, Bruce H., Glick-Wilson, Barbara E., Winkle, Wendy L., Lee Stone, K., Carlson, Kathy A.

“…A convenient procedure by phase transfer catalysis has been developed for the synthesis of O 6 -BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG…”
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Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin by Zwelling, Leonard A, Michaels, Stephen, Erickson, Leonard C, Ungerleider, Richard S, Nichols, Margaret, Kohn, Kurt W

“…The DNA intercalating agents 4'-(9-acridinyl-amino) methanesulfon-m-anisidide (m-AMSA) and adriamycin were studied by using filter elution methods to measure…”
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Synthesis of radiolabeled O6-benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase by Zheng, Qi-Huang, Liu, Xuan, Fei, Xiangshu, Wang, Ji-Quan, Ohannesian, David W., Erickson, Leonard C., Stone, K. Lee, Martinez, Tanya D., Miller, Kathy D., Hutchins, Gary D.

“…Novel radiolabeled O6‐benzylguanine derivatives, 2‐amino‐6‐O‐[11C]‐[(methoxymethyl)benzyloxy]‐9‐benzyl purines ([11C]p‐O6‐AMBP, 1a; [11C]m‐O6‐AMBP, 1b;…”
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DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells by Erickson, Leonard C, Laurent, Guy, Sharkey, Nancy A, Kohn, Kurt W

“…The 1-(2-chloroethyl)-1-nitrosoureas are potent anti-cancer drugs which produce DNA inter-strand cross-links in a two-step reaction sequence. The first step…”
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Af64a-induced changes in N-myc expression in the LA-N-2 human neuroblastoma cell line are modulated by choline and hemicholinium-3 by SANTIAGO, L. R, ERICKSON, L. C, HANIN, I

“…Due to AF64A's structural similarity to choline, AF64A can selectively affect cholinergic neurons, which possess a high affinity choline transport system for…”
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DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one by GIBSON, N. W, HICKMAN, J. A, ERICKSON, L. C

“…Normal (IMR-90) and SV40-transformed (VA-13) human embryo cells were treated with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one (M&B…”
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Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate by DOLAN, M. E, PEGG, A. E, HORA, N. K, ERICKSON, L. C

“…Exposure of HT29 cells in culture to O6-methylguanine is known to result in a reduction in O6-alkylguanine-DNA alkyltransferase (AGT) activity and an…”
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A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase by Kreklau, E L, Limp-Foster, M, Liu, N, Xu, Y, Kelley, M R, Erickson, L C

“…DNA repair status plays a major role in mutagenesis, carcinogenesis and resistance to genotoxic agents. Because DNA repair processes involve multiple enzymatic…”
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Combined effects of streptozotocin and mitozolomide against four human cell lines of the Mer+ phenotype by GIBSON, N. W, HARTLEY, J. A, BARNES, D, ERICKSON, L. C

“…The majority of human tumor cell lines are proficient in the repair of guanine O6-alkylations (designated Mer+) and are thus capable of preventing the…”
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