Search Results - "Erickson, Jon"

Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation by Gao, Yang, Hu, Hongli, Ramachandran, Sekar, Erickson, Jon W., Cerione, Richard A., Skiniotis, Georgios

“…Rhodopsin (Rho), a prototypical G-protein-coupled receptor (GPCR) in vertebrate vision, activates the G-protein transducin (GT) by catalyzing GDP-GTP exchange…”
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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy by Lukey, Michael J., Greene, Kai Su, Erickson, Jon W., Wilson, Kristin F., Cerione, Richard A.

“…Many transformed cells exhibit altered glucose metabolism and increased utilization of glutamine for anabolic and bioenergetic processes. These metabolic…”
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New perspectives in ecosystem services science as instruments to understand environmental securities by Villa, Ferdinando, Voigt, Brian, Erickson, Jon D.

“…As societal demand for food, water and other life-sustaining resources grows, the science of ecosystem services (ES) is seen as a promising tool to improve our…”
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Probabilistic simulation of phosphorus loss using the Vermont P-index: a bottom-up field to watershed approach by Dube, Benjamin, Erickson, Jon D.

“…Anthropogenic nutrient loading from land use, especially agriculture, is a major threat to waterbodies worldwide. Efforts to govern nutrient pollution are…”
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Theoretical Study of Protein–Ligand Interactions Using the Molecules-in-Molecules Fragmentation-Based Method by Thapa, Bishnu, Beckett, Daniel, Erickson, Jon, Raghavachari, Krishnan

“…We have recently significantly expanded the applicability of our Molecules-in-Molecules (MIM) fragmentation method to large proteins by developing a…”
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SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis by Greene, Kai Su, Lukey, Michael J., Wang, Xueying, Blank, Bryant, Druso, Joseph E., Lin, Miao-chong J., Stalnecker, Clint A., Zhang, Chengliang, Abril, Yashira Negrón, Erickson, Jon W., Wilson, Kristin F., Lin, Hening, Weiss, Robert S., Cerione, Richard A.

“…The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated during tumorigenesis and is being evaluated as a target for cancer therapy. GLS catalyzes…”
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Defeat the Peak: Behavioral insights for electricity demand response program design by Pratt, Bonnie Wylie, Erickson, Jon D.

“…•A demand response program with a non-financial incentive was analyzed using a difference-in-differences model.•Altruism was investigated from an…”
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Quantum Mechanical Investigation of Three-Dimensional Activity Cliffs Using the Molecules-in-Molecules Fragmentation-Based Method by Thapa, Bishnu, Erickson, Jon, Raghavachari, Krishnan

“…The concept of activity cliff (AC) (i.e., a small structural modification resulting in a substantial bioactivity change) is widely encountered in medicinal…”
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Phosphorus flows and legacy accumulation in an animal-dominated agricultural region from 1925 to 2012 by Wironen, Michael B., Bennett, Elena M., Erickson, Jon D.

“…•Vermont’s farms accumulated >1000 tonnes of legacy P each year from 1925 to 2012.•P surplus peaked in 1950, declining since, reflecting improved P use…”
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Rethinking the geography of energy transitions: low carbon energy pathways through energyshed design by Thomas, Austin, Erickson, Jon D.

“…•Spatial relationships in energy systems are often hidden or implicit.•Low carbon energy system transitions are strongly influenced by these relationships.•The…”
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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer by Lukey, Michael J., Cluntun, Ahmad A., Katt, William P., Lin, Miao-chong J., Druso, Joseph E., Ramachandran, Sekar, Erickson, Jon W., Le, Henry H., Wang, Zhihan-Emily, Blank, Bryant, Greene, Kai Su, Cerione, Richard A.

“…Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has…”
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Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation by Wang, Jian-Bin, Erickson, Jon W., Fuji, Reina, Ramachandran, Sekar, Gao, Ping, Dinavahi, Ramani, Wilson, Kristin F., Ambrosio, Andre L.B., Dias, Sandra M.G., Dang, Chi V., Cerione, Richard A.

“…Rho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by…”
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Glutaminase: a hot spot for regulation of cancer cell metabolism? by Erickson, Jon W, Cerione, Richard A

“…Cancer cells re-program their metabolic machinery in order to satisfy their bioenergetic and biosynthetic requirements. A critical aspect of the re-programming…”
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Re-establishing Justice as a Pillar of Ecological Economics Through Feminist Perspectives by Spencer, Phoebe, Perkins, Patricia E., Erickson, Jon D.

“…Ecological economics has long claimed distributive justice as a central tenet, yet discussions of equity and justice have received relatively little attention…”
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Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells by Stalnecker, Clint A., Ulrich, Scott M., Li, Yunxing, Ramachandran, Sekar, McBrayer, Mary Kate, DeBerardinis, Ralph J., Cerione, Richard A., Erickson, Jon W.

“…The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamine to glutamate plus ammonia, a key step in the metabolism of glutamine by…”
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Genuine Economic Progress in the United States: A Fifty State Study and Comparative Assessment by Fox, Mairi-Jane V., Erickson, Jon D.

“…The Genuine Progress Indicator (GPI) was designed to reveal the economic, social, and environmental trade-offs associated with conventional economic growth as…”
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KRAS-dependent cancer cells promote survival by producing exosomes enriched in Survivin by Chang, Wen-Hsuan, Nguyen, Thuy-Tien Thi, Hsu, Chia-Hsin, Bryant, Kirsten L., Kim, Hong Jin, Ying, Haoqiang, Erickson, Jon W., Der, Channing J., Cerione, Richard A., Antonyak, Marc A.

“…Mutations in KRAS frequently occur in human cancer and are especially prevalent in pancreatic ductal adenocarcinoma (PDAC), where they have been shown to…”
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Isolation and structure–function characterization of a signaling-active rhodopsin–G protein complex by Gao, Yang, Westfield, Gerwin, Erickson, Jon W., Cerione, Richard A., Skiniotis, Georgios, Ramachandran, Sekar

“…The visual photo-transduction cascade is a prototypical G protein–coupled receptor (GPCR) signaling system, in which light-activated rhodopsin (Rho*) is the…”
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Design and meaning of the genuine progress indicator: A statistical analysis of the U.S. fifty-state model by Fox, Mairi-Jane V., Erickson, Jon D.

“…The Genuine Progress Indicator (GPI) was designed to reveal the trade-offs between costs and benefits of economic growth. Although originally estimated and…”
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Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation by Katt, William P, Ramachandran, Sekar, Erickson, Jon W, Cerione, Richard A

“…One hallmark of cancer cells is their adaptation to rely upon an altered metabolic scheme that includes changes in the glycolytic pathway, known as the Warburg…”
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