Search Results - "Erickson, J W"

Structure-Based Inhibitors of HIV-1 Protease by Wlodawer, A, Erickson, J W

“…This review discusses the current state of structural investigations of HIV-1 PR inhibitor complexes, concentrating on the structure of the enzyme, its mode of…”
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Structure and Inhibition of Plasmepsin II, a Hemoglobin-Degrading Enzyme from Plasmodium falciparum by Silva, A. M., Lee, A. Y., Gulnik, S. V., Majer, P., Collins, J., Bhat, T. N., Collins, P. J., Cachau, R. E., Luker, K. E., Gluzman, I. Y., Francis, S. E., Oksman, A., Goldberg, D. E., Erickson, J. W.

“…Plasmodium falciparum is the major causative agent of malaria, a disease of worldwide importance. Resistance to current drugs such as chloroquine and…”
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The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation by Cerione, Richard A, Wu, Wen Jin, Erickson, Jon W, Lin, Rui

“…The Ras-related GTP-binding protein Cdc42 is implicated in a variety of biological activities including the establishment of cell polarity in yeast, the…”
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Identification of the sigma E subunit of Escherichia coli RNA polymerase: a second alternate sigma factor involved in high-temperature gene expression by Erickson, J W, Gross, C A

“…The rpoH gene of Escherichia coli encodes sigma 32, the 32-kD sigma-factor responsible for the heat-inducible transcription of the heat shock genes. rpoH is…”
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Crystal Structures of Native and Inhibited Forms of Human Cathepsin D: Implications for Lysosomal Targeting and Drug Design by Baldwin, Eric T., Bhat, T. Narayana, Gulnik, Sergei, Hosur, Madhusoodan V., Sowder, Raymond C., Cachau, Raul E., Collins, Jack, Silva, Abelardo M., Erickson, John W.

“…Cathepsin D (EC 3.4.23.5) is a lysosomal protease suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and…”
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Protease inhibitors: resistance, cross-resistance, fitness and the choice of initial and salvage therapies by Erickson, J W, Gulnik, S V, Markowitz, M

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A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli by SINGER, M, BAKER, T. A, SCHNITZLER, G, DEISCHEL, S. M, GOEL, M, DOVE, W, JAACKS, K. J, GROSSMAN, A. D, ERICKSON, J. W, GROSS, C. A

“…We present a collection of 182 isogenic strains containing genetically linked antibiotic resistance elements located at approximately 1-min intervals around…”
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Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor by HO, D. D, TOYOSHIMA, T, HONGMEI MO, KEMPF, D. J, NORBECK, D, CHIH-MING CHEN, WIDEBURG, N. E, BURT, S. K, ERICKSON, J. W, SINGH, M. K

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Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica by Mecsas, J, Welch, R, Erickson, J W, Gross, C A

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Calculation of Relative Binding Free Energies of Peptidic Inhibitors to HIV-1 Protease and Its I84V Mutant by Tawa, G. J, Topol, I. A, Burt, S. K, Erickson, J. W

“…A methodology is presented for calculating relative binding free energies of enzyme−inhibitor associations in aqueous solvent. The methodology uses synthesis…”
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Effects of Si interlayer conditions on platinum ohmic contacts for p-type silicon carbide by JANG, T, ERICKSON, J. W, PORTER, L. M

“…A study of Pt ohmic contacts with Si interlayers on p-type SiC (7.0 x 10 super(18) cm super(-3)) was performed as a function of the Si interlayer thickness,…”
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In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects by Lech, W J, Wang, G, Yang, Y L, Chee, Y, Dorman, K, McCrae, D, Lazzeroni, L C, Erickson, J W, Sinsheimer, J S, Kaplan, A H

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Identification of a Binding Site for the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein by Sakaguchi, Kazuyasu, Zambrano, Nicola, Baldwin, Eric T., Shapiro, Bruce A., Erickson, John W., Omichinski, James G., Clore, G. Marius, Gronenborn, Angela M., Appella, Ettore

“…The nucleocapsid (NC) protein NCp7 of human immunodeficiency virus type 1 (HIV-1) is important for encapsidation of the virus genome, RNA dimerization, and…”
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Slow-cooling protocols for crystallographic refinement by simulated annealing by Brünger, A T, Krukowski, A, Erickson, J W

“…An improved protocol for crystallographic refinement by simulated annealing is presented. It consists of slow cooling starting at high temperatures. Tests of…”
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Selection of Multiple Human Immunodeficiency Virus Type 1 Variants that Encode Viral Proteases with Decreased Sensitivity to an Inhibitor of the Viral Protease by Kaplan, Andrew H., Michael, Scott F., Wehbie, Robert S., Knigge, Mark F., Paul, Deborah A., Everitt, Lorraine, Kempf, Dale J., Norbeck, Daniel W., Erickson, John W., Swanstrom, Ronald

“…Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease represent a promising addition to the available agents used to inhibit virus replication…”
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Interpretation of X chromosome dose at Sex-lethal requires non-E-box sites for the basic helix-loop-helix proteins SISB and daughterless by Yang, D, Lu, H, Hong, Y, Jinks, T M, Estes, P A, Erickson, J W

“…For Drosophila melanogaster flies, sexual fate is determined by the X chromosome number. The basic helix-loop-helix protein product of the X-linked sisterlessB…”
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A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex by ERICKSON, J. W, CLINE, T. W

“…Sexual identity in Drosophila is determined by zygotic X-chromosome dose. Two potent indicators of X-chromosome dose are sisterless-a (sis-a) and sisterless-b…”
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HIV protease: Enzyme function and drug resistance by Gulnik, Sergei, Erickson, John W., Xie, Dong

“…HIV protease is responsible for processing of the gag and gag-pol polyproteins during virion maturation. The activity of this enzyme is essential for virus…”
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New Series of Potent, Orally Bioavailable, Non-Peptidic Cyclic Sulfones as HIV-1 Protease Inhibitors by Kim, Choung U, McGee, Lawrence R, Krawczyk, Steven H, Harwood, Erik, Harada, Yoko, Swaminathan, S, Bischofberger, Norbert, Chen, Ming S, Cherrington, Julie M, Xiong, Shelly F, Griffin, Linda, Cundy, Kenneth C, Lee, Angela, Yu, Betty, Gulnik, Sergli, Erickson, John W

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Real-time DNA binding measurements of the ETS1 recombinant oncoproteins reveal significant kinetic differences between the p42 and p51 isoforms by Fisher, R J, Fivash, M, Casas-Finet, J, Erickson, J W, Kondoh, A, Bladen, S V, Fisher, C, Watson, D K, Papas, T

“…The sequence-specific DNA binding of recombinant p42 and p51 ETS1 oncoprotein was examined quantitatively to determine whether the loss of the Exon VII…”
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