Search Results - "Erickson, Harold"

Size and Shape of Protein Molecules at the Nanometer Level Determined by Sedimentation, Gel Filtration, and Electron Microscopy by Erickson, Harold P.

“…An important part of characterizing any protein molecule is to determine its size and shape. Sedimentation and gel filtration are hydrodynamic techniques that…”
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Progress and Challenges in the Biology of FNDC5 and Irisin by Maak, Steffen, Norheim, Frode, Drevon, Christian A, Erickson, Harold P

“…Abstract In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually…”
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How bacterial cell division might cheat turgor pressure – a unified mechanism of septal division in Gram‐positive and Gram‐negative bacteria by Erickson, Harold P.

“…An important question for bacterial cell division is how the invaginating septum can overcome the turgor force generated by the high osmolarity of the…”
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Liposome division by a simple bacterial division machinery by Osawa, Masaki, 大泽正树, Erickson, Harold P.

“…We previously reconstituted Z rings in tubular multilamellar liposomes with FtsZ-YFP-mts, where mts is a membrane-targeting amphiphilic helix. These…”
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FtsZ in Bacterial Cytokinesis: Cytoskeleton and Force Generator All in One by ERICKSON, Harold P, ANDERSON, David E, OSAWA, Masaki

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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How Teichoic Acids Could Support a Periplasm in Gram-Positive Bacteria, and Let Cell Division Cheat Turgor Pressure by Erickson, Harold P.

“…The cytoplasm of bacteria is maintained at a higher osmolality than the growth medium, which generates a turgor pressure. The cell membrane (CM) cannot support…”
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Microtubule Assembly from Single Flared Protofilaments—Forget the Cozy Corner? by Erickson, Harold P.

“…A paradigm shift for models of MT assembly is suggested by a recent cryo-electron microscopy study of microtubules (MTs). Previous assembly models have been…”
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Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor? by Erickson, Harold P

“…FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the…”
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The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation by Schumacher, Maria A, Chinnam, Nagababu, Ohashi, Tomoo, Shah, Riddhi Sanjay, Erickson, Harold P

“…Irisin was recently identified as a putative myokine that is induced by exercise. Studies suggest that it is produced by cleavage of the FNDC5 (fibronectin…”
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A Unified Model for Treadmilling and Nucleation of Single-Stranded FtsZ Protofilaments by Corbin, Lauren C., Erickson, Harold P.

“…Bacterial cell division is tightly coupled to the dynamic behavior of FtsZ, a tubulin homolog. Recent experimental work in vitro and in vivo has attributed…”
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Irisin – a myth rather than an exercise-inducible myokine by Albrecht, Elke, Norheim, Frode, Thiede, Bernd, Holen, Torgeir, Ohashi, Tomoo, Schering, Lisa, Lee, Sindre, Brenmoehl, Julia, Thomas, Selina, Drevon, Christian A., Erickson, Harold P., Maak, Steffen

“…The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5) and to mediate beneficial effects…”
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Reconstitution of Contractile FtsZ Rings in Liposomes by Osawa, Masaki, Anderson, David E, Erickson, Harold P

“…FtsZ is a tubulin homolog and the major cytoskeletal protein in bacterial cell division. It assembles into the Z ring, which contains FtsZ and a dozen other…”
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Protein unfolding under isometric tension—what force can integrins generate, and can it unfold FNIII domains? by Erickson, Harold P

“…•The isometric tension needed to unfold various protein domains is ∼5pN.•Single integrins generate a force of 1–2pN on the ECM ligand.•2pN would only extend an…”
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L form bacteria growth in low-osmolality medium by Osawa, Masaki, Erickson, Harold P

“…L form bacteria do not have a cell wall and are thought to require medium of high osmolality for survival and growth. In this study we tested whether L forms…”
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Recently Designed Multivalent Spike Binders Cannot Bind MultivalentlyHow Do They Achieve Enhanced Avidity to SARS-CoV-2? by Erickson, Harold P., Corbin Goodman, Lauren

“…The trimeric spike protein of SARS-CoV-2 has been targeted by antibody mimics that bind near or at the receptor-binding domain to neutralize the virus. Several…”
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The discovery of the prokaryotic cytoskeleton: 25th anniversary by Erickson, Harold P

“…The year 2017 marks the 25th anniversary of the discovery of homologues of tubulin and actin in prokaryotes. Before 1992, it was largely accepted that tubulin…”
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Evolution of the cytoskeleton by Erickson, Harold P.

“…The eukaryotic cytoskeleton appears to have evolved from ancestral precursors related to prokaryotic FtsZ and MreB. FtsZ and MreB show 40–50% sequence identity…”
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SulA Inhibits Assembly of FtsZ by a Simple Sequestration Mechanism by Chen, Yaodong, Milam, Sara L, Erickson, Harold P

“…We have investigated the inhibition by SulA of the assembly of Escherichia coli FtsZ. Using quantitative GTPase and fluorescence assays, we found that SulA…”
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Turgor Pressure and Possible Constriction Mechanisms in Bacterial Division by Osawa, Masaki, Erickson, Harold P

“…Bacterial cytokinesis begins with the assembly of FtsZ into a Z ring at the center of the cell. The Z-ring constriction in Gram-negative bacteria may occur in…”
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Probing for Binding Regions of the FtsZ Protein Surface through Site-Directed Insertions: Discovery of Fully Functional FtsZ-Fluorescent Proteins by Moore, Desmond A, Whatley, Zakiya N, Joshi, Chandra P, Osawa, Masaki, Erickson, Harold P

“…FtsZ, a bacterial tubulin homologue, is a cytoskeletal protein that assembles into protofilaments that are one subunit thick. These protofilaments assemble…”
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