Search Results - "Eric T Harvill"

Pathogen manipulation of host metabolism: A common strategy for immune evasion by Freyberg, Zachary, Harvill, Eric T

“…Rapid bursts of cellular proliferative, biosynthetic, and secretory activities by leukocytes require considerable metabolic resources that are especially…”
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Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis by Ma, Longhuan, Caulfield, Amanda, Dewan, Kalyan K, Harvill, Eric T

“…Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN),…”
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Maternal vaccination: shaping the neonatal response to pertussis by Callender, Maiya, Harvill, Eric T

“…Antepartum maternal vaccination can protect highly sensitive newborns before they are old enough to receive their own vaccines. Two vaccines are currently…”
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Koch's curse: How models of extreme pathology bias studies of host-pathogen interactions by Dewan, Kalyan K, Harvill, Eric T

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Making friends: active selection of symbionts and rejection of pathogens by the neonatal immune system by Sedney, Colleen J, Harvill, Eric T

“…The neonatal immune system is generally viewed as deficient compared to adults, often attributed to its incomplete development. This view is reinforced by the…”
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Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes by Paul, Sandip, Bag, Sumit K, Das, Sabyasachi, Harvill, Eric T, Dutta, Chitra

“…Halophilic prokaryotes are adapted to thrive in extreme conditions of salinity. Identification and analysis of distinct macromolecular characteristics of…”
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Generating enhanced mucosal immunity against Bordetella pertussis: current challenges and new directions by Caulfield, Amanda D, Callender, Maiya, Harvill, Eric T

“…is the highly transmissible etiologic agent of pertussis, a severe respiratory disease that causes particularly high morbidity and mortality in infants and…”
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Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice by Soumana, Illiassou Hamidou, Linz, Bodo, Dewan, Kalyan K, Sarr, Demba, Gestal, Monica C, Howard, Laura K, Caulfield, Amanda D, Rada, Balázs, Harvill, Eric T

“…Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic…”
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Evolution and Conservation of Bordetella Intracellular Survival in Eukaryotic Host Cells by Rivera, Israel, Linz, Bodo, Harvill, Eric T.

“…The classical bordetellae possess several partially characterized virulence mechanisms that are studied in the context of a complete extracellular life cycle…”
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Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens by Park, Jihye, Zhang, Ying, Buboltz, Anne M, Zhang, Xuqing, Schuster, Stephan C, Ahuja, Umesh, Liu, Minghsun, Miller, Jeff F, Sebaihia, Mohammed, Bentley, Stephen D, Parkhill, Julian, Harvill, Eric T

“…The classical Bordetella subspecies are phylogenetically closely related, yet differ in some of the most interesting and important characteristics of…”
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Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species by Linz, Bodo, Ivanov, Yury V, Preston, Andrew, Brinkac, Lauren, Parkhill, Julian, Kim, Maria, Harris, Simon R, Goodfield, Laura L, Fry, Norman K, Gorringe, Andrew R, Nicholson, Tracy L, Register, Karen B, Losada, Liliana, Harvill, Eric T

“…The genus Bordetella consists of nine species that include important respiratory pathogens such as the 'classical' species B. bronchiseptica, B. pertussis and…”
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Did new transmission cycles in anthropogenic, dense, host populations encourage the emergence and speciation of pathogenic Bordetella? by Dewan, Kalyan K, Harvill, Eric T

“…About the Authors: Kalyan K. Dewan * E-mail: kaldew@uga.edu Affiliation: Department of Infectious Disease, College of Veterinary Medicine, University of…”
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A model of chronic, transmissible Otitis Media in mice by Dewan, Kalyan K, Taylor-Mulneix, Dawn L, Campos, Laura L, Skarlupka, Amanda L, Wagner, Shannon M, Ryman, Valerie E, Gestal, Monica C, Ma, Longhua, Blas-Machado, Uriel, Faddis, Brian T, Harvill, Eric T

“…Infection and inflammation of the middle ears that characterizes acute and chronic otitis media (OM), is a major reason for doctor visits and antibiotic…”
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Immunomodulation as a Novel Strategy for Prevention and Treatment of Bordetella spp. Infections by Gestal, Monica C, Johnson, Hannah M, Harvill, Eric T

“…Well-adapted pathogens have evolved to survive the many challenges of a robust immune response. Defending against all host antimicrobials simultaneously would…”
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The Neonatal Immune System and Respiratory Pathogens by Sedney, Colleen J, Harvill, Eric T

“…Neonates are more susceptible to some pathogens, particularly those that cause infection in the respiratory tract. This is often attributed to an incompletely…”
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Bordetella bronchiseptica exploits the complex life cycle of Dictyostelium discoideum as an amplifying transmission vector by Taylor-Mulneix, Dawn L, Bendor, Liron, Linz, Bodo, Rivera, Israel, Ryman, Valerie E, Dewan, Kalyan K, Wagner, Shannon M, Wilson, Emily F, Hilburger, Lindsay J, Cuff, Laura E, West, Christopher M, Harvill, Eric T

“…Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined…”
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Pertactin contributes to shedding and transmission of Bordetella bronchiseptica by Ma, Longhuan, Dewan, Kalyan K, Taylor-Mulneix, Dawn L, Wagner, Shannon M, Linz, Bodo, Rivera, Israel, Su, Yang, Caulfield, Amanda D, Blas-Machado, Uriel, Harvill, Eric T

“…Whooping cough is resurging in the United States despite high vaccine coverage. The rapid rise of Bordetella pertussis isolates lacking pertactin (PRN), a key…”
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Novel murine model reveals an early role for pertussis toxin in disrupting neonatal immunity to Bordetella pertussis by Sedney, Colleen J, Caulfield, Amanda, Dewan, Kaylan K, Blas-Machado, Uriel, Callender, Maiya, Manley, Nancy R, Harvill, Eric T

“…The increased susceptibility of neonates to specific pathogens has previously been attributed to an underdeveloped immune system. More recent data suggest…”
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Bordetella parapertussis Circumvents Neutrophil Extracellular Bactericidal Mechanisms by Gorgojo, Juan, Scharrig, Emilia, Gómez, Ricardo M, Harvill, Eric T, Rodríguez, Maria Eugenia

“…B. parapertussis is a whooping cough etiological agent with the ability to evade the immune response induced by pertussis vaccines. We previously demonstrated…”
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Acellular Pertussis Vaccine Components: Today and Tomorrow by Dewan, Kalyan K, Linz, Bodo, DeRocco, Susan E, Harvill, Eric T

“…Pertussis is a highly communicable acute respiratory infection caused by Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks…”
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