Search Results - "Eric M. Mucker"

Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits by Mucker, Eric M., Thiele-Suess, Carolin, Baumhof, Patrick, Hooper, Jay W.

“…Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus…”
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Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease by Golden, Joseph W, Cline, Curtis R, Zeng, Xiankun, Garrison, Aura R, Carey, Brian D, Mucker, Eric M, White, Lauren E, Shamblin, Joshua D, Brocato, Rebecca L, Liu, Jun, Babka, April M, Rauch, Hypaitia B, Smith, Jeffrey M, Hollidge, Bradley S, Fitzpatrick, Collin, Badger, Catherine V, Hooper, Jay W

“…The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical…”
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Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods by Bell, Todd M, Facemire, Paul, Bearss, Jeremy J, Raymond, Jo Lynne, Chapman, Jennifer, Zeng, Xiankun, Shamblin, Joshua D, Williams, Janice A, Grosenbach, Douglas W, Hruby, Dennis E, Damon, Inger K, Goff, Arthur J, Mucker, Eric M

“…Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus. Using…”
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Intranasal monkeypox marmoset model: Prophylactic antibody treatment provides benefit against severe monkeypox virus disease by Mucker, Eric M, Wollen-Roberts, Suzanne E, Kimmel, Adrienne, Shamblin, Josh, Sampey, Darryl, Hooper, Jay W

“…Concerns regarding outbreaks of human monkeypox or the potential reintroduction of smallpox into an immunological naïve population have prompted the…”
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Susceptibility of Marmosets (Callithrix jacchus) to Monkeypox Virus: A Low Dose Prospective Model for Monkeypox and Smallpox Disease by Mucker, Eric M, Chapman, Jennifer, Huzella, Louis M, Huggins, John W, Shamblin, Joshua, Robinson, Camenzind G, Hensley, Lisa E

“…Although current nonhuman primate models of monkeypox and smallpox diseases provide some insight into disease pathogenesis, they require a high titer inoculum,…”
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Effect of Monkeypox Virus Preparation on the Lethality of the Intravenous Cynomolgus Macaque Model by Mucker, Eric M, Shamblin, Josh D, Raymond, Jo Lynne, Twenhafel, Nancy A, Garry, Robert F, Hensley, Lisa E

“…For over two decades, researchers have sought to improve smallpox vaccines and also develop therapies to ensure protection against smallpox or smallpox-like…”
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Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2 by Golden, Joseph W, Li, Rong, Cline, Curtis R, Zeng, Xiankun, Mucker, Eric M, Fuentes-Lao, Amadeo J, Spik, Kristin W, Williams, Janice A, Twenhafel, Nancy, Davis, Neil, Moore, Joshua L, Stevens, Stephen, Blue, Eugene, Garrison, Aura R, Larson, Deanna D, Stewart, Rebekah, Kunzler, Madelyn, Liu, Yanan, Wang, Zhongde, Hooper, Jay W

“…The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global health emergency. While most human disease is mild to…”
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Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox) by MUCKER, Eric M, GOFF, Arthur J, CLEMMONS, Cody J, HUDSON, Paul, HRUBY, Dennis E, SHAMBLIN, Joshua D, GROSENBACH, Douglas W, DAMON, Inger K, MEHAL, Jason M, HOLMAN, Robert C, CARROLL, Darin, GALLARDO, Nadia, OLSON, Victoria A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Development of a specific MPXV antigen detection immunodiagnostic assay by Davis, Ian, Payne, Jackie M., Olguin, Victoria L., Sanders, Madison P., Clements, Tamara, Stefan, Christopher P., Williams, Janice A., Hooper, Jay W., Huggins, John W., Mucker, Eric M., Ricks, Keersten M.

“…Human monkeypox (mpox) has recently become a global public health emergency; however, assays that detect mpox infection are not widely available, largely due…”
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Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2 by Ji, Yun, Zhang, Qi, Cheng, Lin, Ge, Jiwan, Wang, Ruoke, Fang, Mengqi, Mucker, Eric M., Chen, Peng, Ma, Ji, Zhang, Rui, Li, Chunming, Hammond, Holly, Baracco, Lauren, Holbrook, Michael, Frieman, Matthew, Zhang, Zheng, Wang, Xinquan, Hooper, Jay W., Zhang, Linqi, Zhu, Qing

“…Monoclonal antibodies (mAbs) targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein have demonstrated clinical efficacy in…”
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Evaluation of Virulence in Cynomolgus Macaques Using a Virus Preparation Enriched for the Extracellular Form of Monkeypox Virus by Mucker, Eric M, Shamblin, Josh D, Goff, Arthur J, Bell, Todd M, Reed, Christopher, Twenhafel, Nancy A, Chapman, Jennifer, Mattix, Marc, Alves, Derron, Garry, Robert F, Hensley, Lisa E

“…The 2022 global human monkeypox outbreak emphasizes the importance of maintaining poxvirus research, including enriching a basic understanding of animal models…”
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Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries by Yuan, Tom Z, Garg, Pankaj, Wang, Linya, Willis, Jordan R, Kwan, Eric, Hernandez, Ana G Lujan, Tuscano, Emily, Sever, Emily N, Keane, Erica, Soto, Cinque, Mucker, Eric M, Fouch, Mallorie E, Davidson, Edgar, Doranz, Benjamin J, Kailasan, Shweta, Aman, M Javad, Li, Haoyang, Hooper, Jay W, Saphire, Erica Ollmann, Crowe, James E, Liu, Qiang, Axelrod, Fumiko, Sato, Aaron K

“…Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization of monoclonal antibodies…”
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An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection by Golden, Joseph W., Beitzel, Brett, Ladner, Jason T., Mucker, Eric M., Kwilas, Steven A., Palacios, Gustavo, Hooper, Jay W.

“…Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain…”
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Virus-encoded miRNAs in Ebola virus disease by Duy, Janice, Honko, Anna N., Altamura, Louis A., Bixler, Sandra L., Wollen-Roberts, Suzanne, Wauquier, Nadia, O’Hearn, Aileen, Mucker, Eric M., Johnson, Joshua C., Shamblin, Joshua D., Zelko, Justine, Botto, Miriam A., Bangura, James, Coomber, Moinya, Pitt, M. Louise, Gonzalez, Jean-Paul, Schoepp, Randal J., Goff, Arthur J., Minogue, Timothy D.

“…Ebola virus (EBOV) is a negative-strand RNA virus that replicates in the cytoplasm and causes an often-fatal hemorrhagic fever. EBOV, like other viruses, can…”
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Validation of a pan-orthopox real-time PCR assay for the detection and quantification of viral genomes from nonhuman primate blood by Mucker, Eric M, Hartmann, Christopher, Hering, Donna, Giles, Wendy, Miller, David, Fisher, Robert, Huggins, John

“…In 1980, smallpox disease was eradicated from nature and Variola virus, the etiological agent of smallpox, was confined to two laboratories, one located in…”
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Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox by Moss, Bernard, Earl, Patricia L, Americo, Jeffrey L, Wyatt, Linda S, Eller, Leigh Anne, Whitbeck, J. Charles, Cohen, Gary H, Eisenberg, Roselyn J, Hartmann, Christopher J, Jackson, David L, Kulesh, David A, Martinez, Mark J, Miller, David M, Mucker, Eric M, Shamblin, Joshua D, Zwiers, Susan H, Huggins, John W, Jahrling, Peter B

“…The potential use of smallpox as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare…”
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Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease by Mudhasani, Rajini R, Golden, Joseph W, Adam, Gregory C, Hartingh, Timothy J, Kota, Krishna P, Ordonez, David, Quackenbush, Corey R, Tran, Julie P, Cline, Curtis, Williams, Janice A, Zeng, Xiankun, Olsen, David B, Lieberman, Linda A, Boyce, Christopher, Ginnetti, Anthony, Meinig, J Matthew, Panchal, Rekha G, Mucker, Eric M

“…Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox)…”
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SARS-CoV-2 Doggybone DNA Vaccine Produces Cross-Variant Neutralizing Antibodies and Is Protective in a COVID-19 Animal Model by Mucker, Eric M, Brocato, Rebecca L, Principe, Lucia M, Kim, Robert K, Zeng, Xiankun, Smith, Jeffrey M, Kwilas, Steven A, Kim, Sungwon, Horton, Helen, Caproni, Lisa, Hooper, Jay W

“…To combat the COVID-19 pandemic, an assortment of vaccines has been developed. Nucleic acid vaccines have the advantage of rapid production, as they only…”
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Side-by-side comparison of gene-based smallpox vaccine with MVA in nonhuman primates by Golden, Joseph W, Josleyn, Matthew, Mucker, Eric M, Hung, Chien-Fu, Loudon, Peter T, Wu, T C, Hooper, Jay W

“…Orthopoxviruses remain a threat as biological weapons and zoonoses. The licensed live-virus vaccine is associated with serious health risks, making its general…”
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Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure by Malhotra, Shikha, Yen, Judy Y, Honko, Anna N, Garamszegi, Sara, Caballero, Ignacio S, Johnson, Joshua C, Mucker, Eric M, Trefry, John C, Hensley, Lisa E, Connor, John H

“…Lassa virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with LASV leads to the development of…”
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