Search Results - "Eric Hack"

Use of Markov Chain Monte Carlo Analysis with a Physiologically-Based Pharmacokinetic Model of Methylmercury to Estimate Exposures in U.S. Women of Childbearing Age by Allen, Bruce C, Eric Hack, C, Clewell, Harvey J

“…A Bayesian approach, implemented using Markov Chain Monte Carlo (MCMC) analysis, was applied with a physiologically-based pharmacokinetic (PBPK) model of…”
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Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites by Eric Hack, C., Chiu, Weihsueh A., Jay Zhao, Q., Clewell, Harvey J.

“…Bayesian population analysis of a harmonized physiologically based pharmacokinetic (PBPK) model for trichloroethylene (TCE) and its metabolites was performed…”
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Bayesian Network Model for Biomarker-Based Dose Response by Hack, C. Eric, Haber, Lynne T, Maier, Andrew, Shulte, Paul, Fowler, Bruce, Lotz, W. Gregory, Savage Jr., Russell E

“…A Bayesian network model was developed to integrate diverse types of data to conduct an exposure-dose-response assessment for benzene-induced acute myeloid…”
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PBPK model reporting template for chemical risk assessment applications by Tan, Yu-Mei, Chan, Melissa, Chukwudebe, Amechi, Domoradzki, Jeanne, Fisher, Jeffrey, Hack, C. Eric, Hinderliter, Paul, Hirasawa, Kota, Leonard, Jeremy, Lumen, Annie, Paini, Alicia, Qian, Hua, Ruiz, Patricia, Wambaugh, John, Zhang, Fagen, Embry, Michelle

“…Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical…”
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Predicting passive and active tissue:plasma partition coefficients: interindividual and interspecies variability by Ruark, Christopher D, Hack, C Eric, Robinson, Peter J, Mahle, Deirdre A, Gearhart, Jeffery M

“…A mechanistic tissue composition model incorporating passive and active transport for the prediction of steady-state tissue:plasma partition coefficients…”
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An evaluation of the USEPA Proposed Approaches for applying a biologically based dose-response model in a risk assessment for perchlorate in drinking water by Clewell, Harvey J., Gentry, P. Robinan, Hack, C. Eric, Greene, Tracy, Clewell, Rebecca A.

“…The United States Environmental Protection Agency's (USEPA) 2017 report, “Draft Report: Proposed Approaches to Inform the Derivation of a Maximum Contaminant…”
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Dose-Response and Risk Assessment of Airborne Hexavalent Chromium and Lung Cancer Mortality by Crump, Casey, Crump, Kenny, Hack, Eric, Luippold, Rose, Mundt, Kenneth, Liebig, Elizabeth, Panko, Julie, Paustenbach, Dennis, Proctor, Deborah

“…This study evaluates the dose‐response relationship for inhalation exposure to hexavalent chromium [Cr(VI)] and lung cancer mortality for workers of a chromate…”
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Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future by Ellison, Corie A, Api, Anne Marie, Becker, Richard A, Efremenko, Alina Y, Gadhia, Sanket, Hack, C Eric, Hewitt, Nicola J, Varcin, Mustafa, Schepky, Andreas

“…The Threshold of Toxicological Concern (TTC) is a risk assessment tool for evaluating low-level exposure to chemicals with limited toxicological data. A next…”
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A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment by Alexander-White, Camilla, Bury, Dagmar, Cronin, Mark, Dent, Matthew, Hack, Eric, Hewitt, Nicola J., Kenna, Gerry, Naciff, Jorge, Ouedraogo, Gladys, Schepky, Andreas, Mahony, Catherine, Europe, Cosmetics

“…This paper presents a 10-step read-across (RAX) framework for use in cases where a threshold of toxicological concern (TTC) approach to cosmetics safety…”
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Quantitative structure–activity relationships for organophosphates binding to acetylcholinesterase by Ruark, Christopher D., Hack, C. Eric, Robinson, Peter J., Anderson, Paul E., Gearhart, Jeffery M.

“…Organophosphates are a group of pesticides and chemical warfare nerve agents that inhibit acetylcholinesterase, the enzyme responsible for hydrolysis of the…”
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Lipid, water, and protein composition to facilitate kinetic modeling of the auditory pathway by Grobe, Nadja, Narayanan, Latha, Brown, Dominique N., Law, Sarah T., Sibomana, Isaie, Shiyanov, Pavel, Reo, Nicholas V., Hack, C. Eric, Sterner, Teresa R., Mattie, David R.

“…Environments combining JP-8 jet fuel exposure with heightened ambient noise may accelerate hearing loss induced by noise. To reduce animal use and facilitate…”
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Staging of the Baboon Response to Group A Streptococci Administered Intramuscularly: A Descriptive Study of the Clinical Symptoms and Clinical Chemical Response Patterns by Taylor, Fletcher B., Bryant, Amy E., Blick, Kenneth E., Hack, Eric, Jansen, Patty M., Kosanke, Stanley D., Stevens, Dennis L.

“…Group A streptococcal infections, ranging from necrotizing fasciitis and myositis to toxic shock syndrome, have increased over the last 10 years. We developed…”
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New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine by Bury, Dagmar, Alexander-White, Camilla, Clewell, Harvey J., Cronin, Mark, Desprez, Bertrand, Detroyer, Ann, Efremenko, Alina, Firman, James, Hack, Eric, Hewitt, Nicola J., Kenna, Gerry, Klaric, Martina, Lester, Cathy, Mahony, Catherine, Ouedraogo, Gladys, Paini, Alicia, Schepky, Andreas

“…This case study on the model substance caffeine demonstrates the viability of a 10-step read-across (RAX) framework in practice. New approach methodologies…”
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Bayesian analysis of physiologically based toxicokinetic and toxicodynamic models by Hack, C. Eric

“…Physiologically based toxicokinetic (PBTK) and toxicodynamic (TD) models of bromate in animals and humans would improve our ability to accurately estimate the…”
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Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens by Ouedraogo, Gladys, Alexander-White, Camilla, Bury, Dagmar, Clewell, Harvey J., Cronin, Mark, Cull, Tom, Dent, Matthew, Desprez, Bertrand, Detroyer, Ann, Ellison, Corie, Giammanco, Stefania, Hack, Eric, Hewitt, Nicola J., Kenna, Gerry, Klaric, Martina, Kreiling, Reinhard, Lester, Cathy, Mahony, Catherine, Mombelli, Enrico, Naciff, Jorge, O'Brien, John, Schepky, Andreas, Tozer, Sarah, van der Burg, Bart, van Vugt-Lussenburg, Barbara, Stuard, Sharon, Cosmetics Europe

“…Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals,…”
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Quantitative Structure-Activity Relationships for Organophosphates Binding to Trypsin and Chymotrypsin by Ruark, Christopher D., Hack, C. Eric, Robinson, Peter J., Gearhart, Jeffery M.

“…Organophosphate (OP) nerve agents such as sarin, soman, tabun, and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX) do not react solely with…”
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Development of Recombinant Proteins to Treat Chronic Pain by Prado, Judith, Popov-Celeketic, Jelena, Steen-Louws, Cristine, Raoof, Ramin, Hack, Eric, Eijkelkamp, Niels

“…Chronic pain is difficult to treat and new approaches to resolve persistent pain are urgently needed. Anti-inflammatory cytokines are promising candidates for…”
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Development of Recombinant Proteins to Treat Chronic Pain by Prado, Judith, Popov-Celeketic, Jelena, Steen-Louws, Cristine, Raoof, Ramin, Hack, Eric, Eijkelkamp, Niels

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Revised assessment of cancer risk to dichloromethane: Part I Bayesian PBPK and dose–response modeling in mice by Marino, Dale J., Clewell, Harvey J., Gentry, P. Robinan, Covington, Tammie R., Hack, C. Eric, David, Raymond M., Morgott, David A.

“…The current USEPA cancer risk assessment for dichloromethane (DCM) is based on deterministic physiologically based pharmacokinetic (PBPK) modeling involving…”
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An Approach for the Quantitative Consideration of Genetic Polymorphism Data in Chemical Risk Assessment: Examples with Warfarin and Parathion by Gentry, P. Robinan, Hack, C. Eric, Haber, Lynne, Maier, Andrew, Clewell, Harvey J.

“…In recent years, a great deal of research has been conducted to identify genetic polymorphisms. One focus has been to characterize variability in metabolic…”
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