Search Results - "Ergul, Adviye"

Endothelin-1 and diabetic complications: Focus on the vasculature by Ergul, Adviye

“…Diabetes is not only an endocrine but also a vascular disease. Cardiovascular complications are the leading cause of morbidity and mortality associated with…”
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Within the Brain: The Renin Angiotensin System by Jackson, LaDonya, Eldahshan, Wael, Fagan, Susan C, Ergul, Adviye

“…For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently…”
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Cerebrovascular complications of diabetes: focus on cognitive dysfunction by Hardigan, Trevor, Ward, Rebecca, Ergul, Adviye

“…The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive…”
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Impact of diabetes and ischemic stroke on the cerebrovasculature: A female perspective by Wolf, Victoria, Abdul, Yasir, Li, Weiguo, Ergul, Adviye

“…There is a very complex interaction between the brain and the cerebral vasculature to meet the metabolic demands of the brain for proper function. Preservation…”
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Cerebral Microvascular Senescence and Inflammation in Diabetes by Phoenix, Ashley, Chandran, Raghavendar, Ergul, Adviye

“…Stress-induced premature senescence can contribute to the accelerated metabolic aging process in diabetes. Progressive accumulation of senescent cells in the…”
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Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury by Artham, Sandeep, Gao, Fei, Verma, Arti, Alwhaibi, Abdulrahman, Sabbineni, Harika, Hafez, Sherif, Ergul, Adviye, Somanath, Payaningal R.

“…The suppression of Akt1 activity by LPS in pulmonary endothelial cells results in increased FoxO1/3a activation, in turn, leading to increased stromelysin1…”
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Novel Targets and Interventions for Cognitive Complications of Diabetes by Wolf, Victoria, Abdul, Yasir, Ergul, Adviye

“…Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular…”
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Inhibition of Ephrin-B2 in brain pericytes decreases cerebral pathological neovascularization in diabetic rats by Coucha, Maha, Barrett, Amy C, Elgebaly, Mostafa, Ergul, Adviye, Abdelsaid, Mohammed

“…We have previously shown that diabetes causes dysfunctional cerebral neovascularization that increases the risk for cerebrovascular disorders such as stroke…”
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Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke by Jackson, Ladonya, Dumanli, Selin, Johnson, Maribeth H, Fagan, Susan C, Ergul, Adviye

“…Unfortunately, over 40% of stroke victims have pre-existing diabetes which not only increases their risk of stroke up to 2-6 fold, but also worsens both…”
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Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet by Mohamed, Islam N., Hafez, Sherif S., Fairaq, Arwa, Ergul, Adviye, Imig, John D., El-Remessy, Azza B.

“…Aims/hypothesis Obesity and hypertension, known pro-inflammatory states, are identified determinants for increased retinal microvascular abnormalities…”
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Progress and challenges in preclinical stroke recovery research by Wolf, Victoria, Ergul, Adviye

“…Significant innovations in the management of acute ischemic stroke have led to an increased incidence in the long-term complications of stroke. Therefore,…”
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Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes by Prakash, Roshini, Johnson, Maribeth, Fagan, Susan C, Ergul, Adviye

“…We previously reported intense pial cerebral collateralization and arteriogenesis in a mild and lean model of type 2 diabetes (T2D), Goto-Kakizaki (GK) rats…”
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Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke by Hafez, Sherif, Abdelsaid, Mohammed, El-Shafey, Sally, Johnson, Maribeth H, Fagan, Susan C, Ergul, Adviye

“…Acute hyperglycemia worsens the clinical outcomes and exacerbates cerebral hemorrhage after stroke. The mediators of hemorrhagic transformation (HT) in…”
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Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice by Johansen, Jeanette Schultz, Harris, Alex K, Rychly, David J, Ergul, Adviye

“…Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality…”
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Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice by Ishrat, Tauheed, Mohamed, Islam N., Pillai, Bindu, Soliman, Sahar, Fouda, Abdelrahman Y., Ergul, Adviye, El-Remessy, Azza B., Fagan, Susan C.

“…Redox imbalance in the brain significantly contributes to ischemic stroke pathogenesis, but antioxidant therapies have failed in clinical trials. Activation of…”
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Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes by Hardigan, Trevor, Abdul, Yasir, Ergul, Adviye

“…The anti-hyperglycemic agent linagliptin, a dipeptidyl peptidase-4 inhibitor, has been shown to reduce inflammation and improve endothelial cell function. In…”
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RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial by Ahmed, Heba A, Ishrat, Tauheed, Pillai, Bindu, Fouda, Abdelrahman Y, Sayed, Mohammed A, Eldahshan, Wael, Waller, Jennifer L, Ergul, Adviye, Fagan, Susan C

“…With the aging population, the prevalence and incidence of cerebrovascular disease will continue to rise, as well as the number of individuals with vascular…”
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Cerebrovascular complications of diabetes: focus on stroke by Ergul, Adviye, Kelly-Cobbs, Aisha, Abdalla, Maha, Fagan, Susan C

“…Cerebrovascular complications make diabetic patients 2-6 times more susceptible to a stroke event and this risk is magnified in younger individuals and in…”
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Delayed Administration of Angiotensin Receptor (AT2R) Agonist C21 Improves Survival and Preserves Sensorimotor Outcomes in Female Diabetic Rats Post-Stroke through Modulation of Microglial Activation by Jackson-Cowan, LaDonya, Eldahshan, Wael, Dumanli, Selin, Dong, Guangkuo, Jamil, Sarah, Abdul, Yasir, Althomali, Waleed, Baban, Babak, Fagan, Susan C, Ergul, Adviye

“…About 70% of stroke victims present with comorbid diseases such as diabetes and hypertension. The integration of comorbidities in pre-clinical experimental…”
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Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in Diet-Induced Obesity by LYNCH, Cynthia M, KINZENBAW, Dale A, XUNXHENG CHEN, SHANSHAN ZHAN, MEZZETTI, Erin, FILOSA, Jessica, ERGUL, Adviye, FAULKNER, Jessica L, FARACI, Frank M, DIDION, Sean P

“…Obesity is an increasing epidemic worldwide; however, little is known about effects of obesity produced by high-fat diet (HFD) on the cerebral circulation. The…”
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