Protective effects of N-acetylcysteine and erdosteine on hemorrhagic shock-induced acute lung injury

BACKGROUNDThe drugs N-acetylcysteine and erdosteine were used to evaluate their protective effects in hemorrhagic shock-induced acute lung injury in an animal model. METHODSForty rats were used and randomly allocated into four groups (n=10). Animals in group III were fed with water containing 1 mg/d...

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Published in:	European journal of emergency medicine Vol. 13; no. 5; pp. 281 - 285
Main Authors:	Alkan, Aysegül, Eroğlu, Füsun, Eroğlu, Erol, Ergin, Çağr, Çerçi, Celal, Alsancak, Güleren
Format:	Journal Article
Language:	English
Published:	England Lippincott Williams & Wilkins, Inc 01-10-2006
Subjects:	Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Animals Blood Pressure Bronchoalveolar Lavage Fluid - chemistry Disease Models, Animal Free Radical Scavengers - pharmacology Free Radical Scavengers - therapeutic use Glutathione - blood Glutathione - metabolism Lung - drug effects Macrophages, Alveolar Male Malondialdehyde - blood Malondialdehyde - metabolism Neutrophils Premedication Random Allocation Rats Rats, Wistar Respiratory Distress Syndrome, Adult - prevention & control Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - metabolism Thioglycolates - pharmacology Thioglycolates - therapeutic use Thiophenes - pharmacology Thiophenes - therapeutic use
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Summary:	BACKGROUNDThe drugs N-acetylcysteine and erdosteine were used to evaluate their protective effects in hemorrhagic shock-induced acute lung injury in an animal model. METHODSForty rats were used and randomly allocated into four groups (n=10). Animals in group III were fed with water containing 1 mg/dl erdosteine, and those in group IV were given 0.5 mg/dl N-acetylcysteine 3 days before the experiment. Group I was taken as the control and group II was taken as the hemorrhagic shock group. Hemorrhagic shock was initiated by blood withdrawal and reduction of the mean arterial pressure to 40 mmHg within 10 min via the right carotid artery. After a hypotensive period of 2 h, animals were resuscitated by transfusion of the shed blood and Ringer lactate in a volume equal to the shed blood. After a period of 1 h, blood samples were taken via the carotid artery. Bronchoalveolar lavage was performed to recover cells from the alveolar space with 40 ml of bronchoalveolar lavage fluid. Lung tissues were also resected to measure tissue malondialdehyde and L-γ-glutamyl-L-cysteinyl-glycine levels with high performance liquid chromatography. The numbers of neutrophils and alveolar macrophages in bronchoalveolar lavage fluid were counted. RESULTSSerum malondialdehyde levels were significantly higher in the shock groups (P<0.05), but there was no significant difference (P>0.05). Lung malondialdehyde levels were also significantly increased in the shock groups (P<0.05). In the erdosteine-applied group, tissue malondialdehyde levels were lower than in group II and the NAC-applied group (P<0.05). In the analyses of serum and lung tissue L-γ-glutamyl-L-cysteinyl-glycine, the values of groups I, II and IV were found to be below the calibration graphics. The alveolar macrophage count was found to be the highest and the neutrophil count the lowest in group III when compared with the other groups in bronchoalveolar lavage fluid analyses (P<0.05). CONCLUSIONWe may say that in the model of hemorrhagic shock-induced acute lung injury, it was found that erdosteine has a protective effect on lung tissue.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0969-9546 1473-5695
DOI:	10.1097/00063110-200610000-00007