Search Results - "Erdozáin, M."
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Oxytocin as Treatment for Social Cognition, Not There Yet
Published in Frontiers in psychiatry (09-01-2020)“…In a short time, oxytocin has progressed from being a regular hormone involved in parturition and breastfeeding to be possibly the neuromodulator that has…”
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G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism
Published in Frontiers in cellular neuroscience (30-10-2020)“…A major challenge in the development of pharmacotherapies for autism is the failure to identify pathophysiological mechanisms that could be targetable. The…”
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3
Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
Published in Translational psychiatry (23-02-2024)“…Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu 2 R and mGlu 3 R) in brains of schizophrenia patients may…”
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4
Alcohol-related brain damage in humans
Published in PloS one (03-04-2014)“…Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human…”
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The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder
Published in Biomolecules (Basel, Switzerland) (01-01-2023)“…Astrocytic-secreted matricellular proteins have been shown to influence various aspects of synaptic function. More recently, they have been found altered in…”
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Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury
Published in Biochemical and biophysical research communications (13-03-2015)“…We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl…”
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Guanidine and 2-Aminoimidazoline Aromatic Derivatives as α2-Adrenoceptor Antagonists. 2. Exploring Alkyl Linkers for New Antidepressants
Published in Journal of medicinal chemistry (12-06-2008)“…The preparation of a number of (bis)guanidine and (bis)2-aminoimidazoline derivatives as potential α2-adrenoceptor antagonists for the treatment of depression…”
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8
Neurobiological alterations in alcohol addiction: a review
Published in Adicciones (Palma de Mallorca) (01-01-2014)“…The exact mechanism by which ethanol exerts its effects on the brain is still unknown. However, nowadays it is well known that ethanol interacts with specific…”
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The Loss of α- and β-Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing
Published in Brain sciences (11-09-2018)“…Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human tissue from…”
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10
In need of a specific antibody against the oxytocin receptor for neuropsychiatric research: A KO validation study
Published in Journal of psychiatric research (01-05-2024)“…Antibodies are one of the most utilized tools in biomedical research. However, few of them are rigorously evaluated, as there are no accepted guidelines or…”
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Characterization of Hevin (SPARCL1) Immunoreactivity in Postmortem Human Brain Homogenates
Published in Neuroscience (15-07-2021)“…•Two forms of protein hevin, differentially glycosylated, are detected in human brain: 130 kDa and 100 kDa.•Hevin expression is higher in prefrontal cortex…”
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12
Maternal Immune Activation Induces Cortical Catecholaminergic Hypofunction and Cognitive Impairments in Offspring
Published in Journal of neuroimmune pharmacology (01-09-2023)“…Background Impairment of specific cognitive domains in schizophrenia has been associated with prefrontal cortex (PFC) catecholaminergic deficits. Among other…”
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13
α2A- and α2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects
Published in European neuropsychopharmacology (01-11-2021)“…•α2A- and α2C-adrenoceptor protein expression was determined by Western Blot in the postmortem prefrontal cortex of 24 subjects with schizophrenia and 24…”
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14
Spinophilin expression in postmortem prefrontal cortex of schizophrenic subjects: Effects of antipsychotic treatment
Published in European neuropsychopharmacology (01-01-2021)“…•Spinophilin protein expression was determined by western blot in DLPFC of 24 schizophrenia subjects and 24 matched controls.•Experiments were performed in…”
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15
Differential α 2A - and α 2C -adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex
Published in Journal of psychopharmacology (Oxford) (01-02-2019)“…Three different α -adrenoceptor (α -AR) subtypes have been described. The α -AR and α -AR subtypes are highly expressed in the human prefrontal cortex, where…”
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16
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
Published in Drug design, development and therapy (01-01-2014)“…Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and…”
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Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane
Published in The Journal of biological chemistry (17-07-2015)“…Dopamine (DA) is a major regulator of sensorimotor and cognitive functions. The DA transporter (DAT) is the key protein that regulates the spatial and temporal…”
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Involvement of the endocannabinoid system in alcohol dependence: The biochemical, behavioral and genetic evidence
Published in Drug and alcohol dependence (01-09-2011)“…Abstract Background Recent advances in the understanding of alcohol dependence suggest that the endocannabinoid system (ECS) plays a key role in the…”
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Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions
Published in Neuropsychopharmacology (01-04-2018)“…The importance of dopamine (DA) neurotransmission is emphasized by its direct implication in several neurological and psychiatric disorders. The DA transporter…”
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Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons
Published in Brain Structure and Function (01-04-2019)“…Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated…”
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