Search Results - "Erdmann, V. A."

Design of antisense oligonucleotides stabilized by locked nucleic acids by Kurreck, Jens, Wyszko, Eliza, Gillen, Clemens, Erdmann, Volker A.

“…The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides,…”
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Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban by FECHNER, H, SUCKAU, L, VETTER, R, ERDMANN, V. A, SCHULTHEISS, H.-P, PAUL, M, LAMERS, J, POLLER, W, KURRECK, J, SIPO, I, WANG, X, PINKERT, S, LOSCHEN, S, REKITTKE, J, WEGER, S, DEKKERS, D

“…Impaired function of the phospholamban (PLB)-regulated sarcoplasmic reticulum Ca(2+) pump (SERCA2a) contributes to cardiac dysfunction in heart failure (HF)…”
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Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′‐O‐methyl RNA, phosphorothioates and small interfering RNA by Grünweller, Arnold, Wyszko, Eliza, Bieber, Birgit, Jahnel, Ricarda, Erdmann, Volker A., Kurreck, Jens

“…Locked nucleic acids (LNAs) and double‐stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for cell culture and in vivo…”
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High-Affinity RNA as a Recognition Element in a Biosensor by Kleinjung, F, Klussmann, S, Erdmann, V. A, Scheller, F. W, Fürste, J. P, Bier, F. F

“…A biosensor for l-adenosine employing high-affinity RNA as binder is reported. Real-time measurement is obtained using total internal reflection fluorescence…”
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Mirror-image RNA that binds D-adenosine by Klußmann, Sven, Nolte, Alexis, Bald, Rolf, Erdmann, Volker A, Fürste, Jens P

“…A 58-mer L-RNA ligand that binds to naturally occurring D-adenosine with a dissociation constant of 1.7 microM in solution was identified from a combinatorial…”
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The non-coding RNAs as riboregulators by Erdmann, V A, Barciszewska, M Z, Szymanski, M, Hochberg, A, de Groot, N, Barciszewski, J

“…The non-coding RNAs database (http://biobases.ibch.poznan.pl/ncRNA/) contains currently available data on RNAs, which do not have long open reading frames and…”
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Regulatory RNAs by Erdmann, V A, Barciszewska, M Z, Hochberg, A, de Groot, N, Barciszewski, J

“…In addition to mRNA, rRNA and tRNA, which play central roles within cells, there are a number of regulatory, non-coding RNAs (ncRNAs). Of varying lengths,…”
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Non-coding, mRNA-like RNAs database Y2K by Erdmann, V A, Szymanski, M, Hochberg, A, Groot, N, Barciszewski, J

“…In last few years much data has accumulated on various non-translatable RNA transcripts that are synthesised in different cells. They are lacking in protein…”
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Mirror-design of L -oligonucleotide ligands binding to L -arginine by Nolte, Alexis, Klußmann, Sven, Bald, Rolf, Erdmann, Volker A, Fürste, Jens P

“…The high affinity and selectivity of nucleic acid ligands have clearly demonstrated that RNA can be targeted to a variety of molecules. In practice, however,…”
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First look at RNA in l-configuration by Vallazza, M., Perbandt, M., Klussmann, S., Rypniewski, W., Einspahr, H. M., Erdmann, V. A., Betzel, Ch

“…Nucleic acid molecules in the mirror image or l‐configuration are unknown in nature and are extraordinarily resistant to biological degradation. The…”
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Local RNA Target Structure Influences siRNA Efficacy: Systematic Analysis of Intentionally Designed Binding Regions by Schubert, Steffen, Grünweller, Arnold, Erdmann, Volker A., Kurreck, Jens

“…Contradictory reports in the literature have emphasised either the sequence of small interfering RNAs (siRNA) or the structure of their target molecules to be…”
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Identification of the phosphorylation sites of the murine small heat shock protein hsp25 by GAESTEL, M, SCHRODER, W, BENNDORF, R, LIPPMANN, C, BUCHNER, K, HUCHO, F, ERDMANN, V. A, BIELKA, H

“…Native phosphorylated mouse small heat shock protein hsp25 from Ehrlich ascites tumor cells was isolated and the in vivo phosphorylation sites of the protein…”
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Cell-Free Expression of Two Single-Chain Monoclonal Antibodies against Lysozyme: Effect of Domain Arrangement on the Expression by Merk, Helmut, Stiege, Wolfgang, Tsumoto, Kouhei, Kumagai, Izumi, Erdmann, Volker A.

“…Single-chain antibodies (scFv), which can be produced in Escherichia coli cells, have been shown in numerous cases to be active in antigen binding. In the case…”
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Collection of mRNA-like non-coding RNAs by Erdmann, V.A, Szymanski, M, Hochberg, A, De Groot, N, Barciszewski, J

“…In last few years much data has accumulated which shows that in different cells various RNA transcripts are synthesized. They lack protein coding capacity and…”
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The product of the imprinted H19 gene is an oncofetal RNA by Ariel, I, Ayesh, S, Perlman, E J, Pizov, G, Tanos, V, Schneider, T, Erdmann, V A, Podeh, D, Komitowski, D, Quasem, A S, de Groot, N, Hochberg, A

“…AIMS/BACKGROUND: The H19 gene is an imprinted, maternally expressed gene in humans. It is tightly linked and coregulated with the imprinted, paternally…”
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Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo by Christoph, Thomas, Grünweller, Arnold, Mika, Joanna, Schäfer, Martin K.-H., Wade, Erik J., Weihe, Eberhard, Erdmann, Volker A., Frank, Robert, Gillen, Clemens, Kurreck, Jens

“…RNA interference (RNAi) has proven to be a powerful technique to study the function of genes by producing knock-down phenotypes. Here, we report that…”
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RNA cleaving ‘10‐23’ DNAzymes with enhanced stability and activity by Schubert, Steffen, Gül, Deniz C., Grunert, Hans‐Peter, Zeichhardt, Heinz, Erdmann, Volker A., Kurreck, Jens

“…‘10‐23’ DNAzymes can be used to cleave any target RNA in a sequence‐specific manner. For applications in vivo, they have to be stabilised against nucleolytic…”
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Compilation of 5S rRNA and 5S rRNA gene sequences by WOLTERS, J, ERDMANN, V. A

“…The BERLIN RNA DATABANK as of December 31, 1987, contains a total of 509 sequences of 5S rRNAs or their genes, which is an increase of 45% over the last (1986)…”
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5S Ribosomal RNA Database by Szymanski, Maciej, Barciszewska, Miroslawa Z, Erdmann, Volker A, Barciszewski, Jan

“…Ribosomal 5S RNA (5S rRNA) is an integral component of the large ribosomal subunit in all known organisms with the exception only of mitochondrial ribosomes of…”
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Crystallization of engineered Thermus flavus 5S rRNA under earth and microgravity conditions by Lorenz, S., Perbandt, M., Lippmann, C., Moore, K., DeLucas, L. J., Betzel, Ch, Erdmann, V. A.

“…Thermus flavus 5S rRNA with a molecular weight of about 40 kDa was modified at the 5′ and 3′ ends. Crystals were obtained under earth and microgravity…”
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