Search Results - "Erdmann, Jeanette"

What can we learn from common variants associated with unexpected phenotypes in rare genetic diseases? by Erdmann, Jeanette

“…The purpose of this article is to stimulate discussion about whether a phenome-wide association study is a suitable tool for uncovering late-onset risks in…”
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A decade of genome-wide association studies for coronary artery disease: the challenges ahead by Erdmann, Jeanette, Kessler, Thorsten, Munoz Venegas, Loreto, Schunkert, Heribert

“…Abstract In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The…”
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ANGPTL3 Deficiency and Protection Against Coronary Artery Disease by Stitziel, Nathan O., MD, PhD, Khera, Amit V., MD, Wang, Xiao, PhD, Bierhals, Andrew J., MD, MPH, Vourakis, A. Christina, BA, Sperry, Alexandra E., BA, Natarajan, Pradeep, MD, Klarin, Derek, MD, Emdin, Connor A., DPhil, Zekavat, Seyedeh M., BSc, Nomura, Akihiro, MD, Erdmann, Jeanette, PhD, Schunkert, Heribert, MD, Samani, Nilesh J., MD, Kraus, William E., MD, Shah, Svati H., MD, MPH, Yu, Bing, PhD, Boerwinkle, Eric, PhD, Rader, Daniel J., MD, Gupta, Namrata, PhD, Frossard, Philippe M., PhD, Rasheed, Asif, MBBS, Danesh, John, DPhil, Lander, Eric S., PhD, Gabriel, Stacey, PhD, Saleheen, Danish, MBBS, PhD, Musunuru, Kiran, MD, PhD, MPH, Kathiresan, Sekar, MD

“…Abstract Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by…”
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Genome-wide association studies of cardiovascular disease by Walsh, Roddy, Jurgens, Sean J, Erdmann, Jeanette, Bezzina, Connie R

“…Genome-wide association studies (GWAS) aim to identify common genetic variants that are associated with traits and diseases. Since 2005, more than 5,000 GWAS…”
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DNA methylation and body-mass index: a genome-wide analysis by Dick, Katherine J, PhD, Nelson, Christopher P, PhD, Tsaprouni, Loukia, PhD, Sandling, Johanna K, PhD, Aïssi, Dylan, MSc, Wahl, Simone, MSc, Meduri, Eshwar, PhD, Morange, Pierre-Emmanuel, Prof, Gagnon, France, PhD, Grallert, Harald, PhD, Waldenberger, Melanie, PhD, Peters, Annette, Prof, Erdmann, Jeanette, Prof, Hengstenberg, Christian, Prof, Cambien, Francois, Prof, Goodall, Alison H, Prof, Ouwehand, Willem H, Prof, Schunkert, Heribert, Prof, Thompson, John R, Prof, Spector, Tim D, FRCP, Gieger, Christian, PhD, Trégouët, David-Alexandre, PhD, Deloukas, Panos, Prof, Samani, Nilesh J, Prof

“…Summary Background Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although…”
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A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease by Emdin, Connor A, Haas, Mary E, Khera, Amit V, Aragam, Krishna, Chaffin, Mark, Klarin, Derek, Hindy, George, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Karjalainen, Juha, Havulinna, Aki, Kiiskinen, Tuomo, Bick, Alexander, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Chang, Kyong-Mi, Vujkovic, Marijana, Voight, Ben, Damrauer, Scott, Lynch, Julie, Kaplan, David, Serper, Marina, Tsao, Philip, Mercader, Josep, Hanis, Craig, Daly, Mark, Denny, Joshua, Gabriel, Stacey, Kathiresan, Sekar

“…Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime…”
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Assessing the causal association of glycine with risk of cardio-metabolic diseases by Wittemans, Laura B. L., Lotta, Luca A., Oliver-Williams, Clare, Stewart, Isobel D., Surendran, Praveen, Karthikeyan, Savita, Day, Felix R., Koulman, Albert, Imamura, Fumiaki, Zeng, Lingyao, Erdmann, Jeanette, Schunkert, Heribert, Khaw, Kay-Tee, Griffin, Julian L., Forouhi, Nita G., Scott, Robert A., Wood, Angela M., Burgess, Stephen, Howson, Joanna M. M., Danesh, John, Wareham, Nicholas J., Butterworth, Adam S., Langenberg, Claudia

“…Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains…”
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ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1 by Kessler, Thorsten, Zhang, Lu, Liu, Ziyi, Yin, Xiaoke, Huang, Yaqian, Wang, Yingbao, Fu, Yi, Mayr, Manuel, Ge, Qing, Xu, Qingbo, Zhu, Yi, Wang, Xian, Schmidt, Kjestine, de Wit, Cor, Erdmann, Jeanette, Schunkert, Heribert, Aherrahrou, Zouhair, Kong, Wei

“…ADAMTS-7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was recently identified to be significantly associated…”
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Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction by Verovenko, Viktor, Tennstedt, Stephanie, Kleinecke, Mariana, Kessler, Thorsten, Schunkert, Heribert, Erdmann, Jeanette, Ensminger, Stephan, Aherrahrou, Zouhair

“…A positive family history is a major independent risk factor for atherosclerosis, and genetic variation is an important aspect of cardiovascular disease…”
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LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study by Silbernagel, Günther, Scharnagl, Hubert, Kleber, Marcus E., Delgado, Graciela, Stojakovic, Tatjana, Laaksonen, Reijo, Erdmann, Jeanette, Rankinen, Tuomo, Bouchard, Claude, Landmesser, Ulf, Schunkert, Heribert, März, Winfried, Grammer, Tanja B.

“…High concentrations of low density lipoprotein (LDL) triglycerides have been associated with prevalent angiographic coronary artery disease. The present…”
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Qtlizer: comprehensive QTL annotation of GWAS results by Munz, Matthias, Wohlers, Inken, Simon, Eric, Reinberger, Tobias, Busch, Hauke, Schaefer, Arne S., Erdmann, Jeanette

“…Exploration of genetic variant-to-gene relationships by quantitative trait loci such as expression QTLs is a frequently used tool in genome-wide association…”
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Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease by Mäkinen, Ville-Petteri, Civelek, Mete, Meng, Qingying, Zhang, Bin, Zhu, Jun, Levian, Candace, Huan, Tianxiao, Segrè, Ayellet V, Ghosh, Sujoy, Vivar, Juan, Nikpay, Majid, Stewart, Alexandre F R, Nelson, Christopher P, Willenborg, Christina, Erdmann, Jeanette, Blakenberg, Stefan, O'Donnell, Christopher J, März, Winfried, Laaksonen, Reijo, Epstein, Stephen E, Kathiresan, Sekar, Shah, Svati H, Hazen, Stanley L, Reilly, Muredach P, Lusis, Aldons J, Samani, Nilesh J, Schunkert, Heribert, Quertermous, Thomas, McPherson, Ruth, Yang, Xia, Assimes, Themistocles L

“…The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite recent successes of genome-wide association studies (GWAS) in…”
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Genomewide Association Analysis of Coronary Artery Disease by Samani, Nilesh J, Erdmann, Jeanette, Hall, Alistair S, Hengstenberg, Christian, Mangino, Massimo, Mayer, Bjoern, Dixon, Richard J, Meitinger, Thomas, Braund, Peter, Wichmann, H.-Erich, Barrett, Jennifer H, König, Inke R, Stevens, Suzanne E, Szymczak, Silke, Tregouet, David-Alexandre, Iles, Mark M, Pahlke, Friedrich, Pollard, Helen, Lieb, Wolfgang, Cambien, Francois, Fischer, Marcus, Ouwehand, Willem, Blankenberg, Stefan, Balmforth, Anthony J, Baessler, Andrea, Ball, Stephen G, Strom, Tim M, Brænne, Ingrid, Gieger, Christian, Deloukas, Panos, Tobin, Martin D, Ziegler, Andreas, Thompson, John R, Schunkert, Heribert

“…Using the technique of genomewide association analysis, the authors found a locus on chromosome 9 (9p21.3) that is strongly associated with familial coronary…”
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Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease by Hartiala, Jaana A., Wilson Tang, W. H., Wang, Zeneng, Crow, Amanda L., Stewart, Alexandre F. R., Roberts, Robert, McPherson, Ruth, Erdmann, Jeanette, Willenborg, Christina, Hazen, Stanley L., Allayee, Hooman

“…Metabolites derived from dietary choline and L -carnitine, such as trimethylamine N -oxide and betaine, have recently been identified as novel risk factors for…”
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Genome-wide association study in takotsubo syndrome — Preliminary results and future directions by Eitel, Ingo, Moeller, Christian, Munz, Matthias, Stiermaier, Thomas, Meitinger, Thomas, Thiele, Holger, Erdmann, Jeanette

“…Abstract Background Takotsubo syndrome (TS) is an acute non-ischemic cardiomyopathy characterized by transient regional systolic dysfunction of the left and/or…”
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Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies by Reilly, Muredach P, Dr, Li, Mingyao, PhD, He, Jing, PhD, Ferguson, Jane F, PhD, Stylianou, Ioannis M, PhD, Mehta, Nehal N, MD, Burnett, Mary Susan, PhD, Devaney, Joseph M, PhD, Knouff, Christopher W, MD, Thompson, John R, Prof, Horne, Benjamin D, PhD, Stewart, Alexandre FR, PhD, Assimes, Themistocles L, MD, Wild, Philipp S, MD, Allayee, Hooman, PhD, Nitschke, Patrick Linsel, MD, Patel, Riyaz S, MD, Martinelli, Nicola, MD, Girelli, Domenico, Prof, Quyyumi, Arshed A, Prof, Anderson, Jeffrey L, Prof, Erdmann, Jeanette, Prof, Hall, Alistair S, MD, Schunkert, Heribert, Prof, Quertermous, Thomas, Prof, Blankenberg, Stefan, Prof, Hazen, Stanley L, Prof, Roberts, Robert, Prof, Kathiresan, Sekar, MD, Samani, Nilesh J, Prof, Epstein, Stephen E, Prof, Rader, Daniel J, Prof

“…Summary Background We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial…”
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The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets by Nording, Henry, Baron, Lasse, Haberthür, David, Emschermann, Frederic, Mezger, Matthias, Sauter, Manuela, Sauter, Reinhard, Patzelt, Johannes, Knoepp, Kai, Nording, Anne, Meusel, Moritz, Meyer-Saraei, Roza, Hlushchuk, Ruslan, Sedding, Daniel, Borst, Oliver, Eitel, Ingo, Karsten, Christian M., Feil, Robert, Pichler, Bernd, Erdmann, Jeanette, Verschoor, Admar, Chavakis, Emmanouil, Chavakis, Triantafyllos, von Hundelshausen, Philipp, Köhl, Jörg, Gawaz, Meinrad, Langer, Harald F.

“…Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified…”
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Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study by Gamil, Sahar, Erdmann, Jeanette, Abdalrahman, Ihab B, Mohamed, Abdelrahim O

“…Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular…”
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A trans -acting locus regulates an anti-viral expression network and type 1 diabetes risk by Hubner, Norbert, Cook, Stuart A, Heinig, Matthias, Petretto, Enrico, Wallace, Chris, Bottolo, Leonardo, Rotival, Maxime, Lu, Han, Li, Yoyo, Sarwar, Rizwan, Langley, Sarah R, Bauerfeind, Anja, Hummel, Oliver, Lee, Young-Ae, Paskas, Svetlana, Rintisch, Carola, Saar, Kathrin, Cooper, Jason, Buchan, Rachel, Gray, Elizabeth E, Cyster, Jason G, Erdmann, Jeanette, Hengstenberg, Christian, Maouche, Seraya, Ouwehand, Willem H, Rice, Catherine M, Samani, Nilesh J, Schunkert, Heribert, Goodall, Alison H, Schulz, Herbert, Roider, Helge G, Vingron, Martin, Blankenberg, Stefan, Münzel, Thomas, Zeller, Tanja, Szymczak, Silke, Ziegler, Andreas, Tiret, Laurence, Smyth, Deborah J, Pravenec, Michal, Aitman, Timothy J, Cambien, Francois, Clayton, David, Todd, John A

“…Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from…”
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Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease by Emdin, Connor A., Khera, Amit V., Chaffin, Mark, Klarin, Derek, Natarajan, Pradeep, Aragam, Krishna, Haas, Mary, Bick, Alexander, Zekavat, Seyedeh M., Nomura, Akihiro, Ardissino, Diego, Wilson, James G., Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J., Samani, Nilesh J., Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Chasman, Daniel, Ridker, Paul, Denny, Joshua, Bastarache, Lisa, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Spertus, John A., Sheu, Wayne H.-H., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Rotter, Jerome I., Chen, Yii-Der Ida, Krumholz, Harlan, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar

“…Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or…”
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