Search Results - "Erdmann, A."

To protect and modify double-stranded RNA - the critical roles of ADARs in development, immunity and oncogenesis by Erdmann, Emily A, Mahapatra, Ananya, Mukherjee, Priyanka, Yang, Boyoon, Hundley, Heather A

“…Adenosine deaminases that act on RNA (ADARs) are present in all animals and function to both bind double-stranded RNA (dsRNA) and catalyze the deamination of…”
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An advanced genetic toolkit for exploring the biology of the rock-inhabiting black fungus Knufia petricola by Voigt, Oliver, Knabe, Nicole, Nitsche, Sarah, Erdmann, Eileen A., Schumacher, Julia, Gorbushina, Anna A.

“…Microcolonial black fungi are a group of ascomycetes that exhibit high stress tolerance, yeast-like growth and constitutive melanin formation. They dominate a…”
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A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis by Novotna, A., Mares, J., Ratcliffe, S., Novakova, I., Vachova, M., Zapletalova, O., Gasperini, C., Pozzilli, C., Cefaro, L., Comi, G., Rossi, P., Ambler, Z., Stelmasiak, Z., Erdmann, A., Montalban, X., Klimek, A., Davies, P.

“…Background:  Spasticity is a disabling complication of multiple sclerosis, affecting many patients with the condition. We report the first Phase 3…”
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ADBP-1 regulates ADR-2 nuclear localization to control editing substrate selection by Eliad, Berta, Schneider, Noa, Ben-Naim Zgayer, Orna, Amichan, Yarden, Glaser, Fabian, Erdmann, Emily A, Rajendren, Suba, Hundley, Heather A, Lamm, Ayelet T

“…Abstract Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a prevalent and conserved RNA modification. While A-to-I RNA editing is…”
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Probing the SELEX process with next-generation sequencing by Schütze, Tatjana, Wilhelm, Barbara, Greiner, Nicole, Braun, Hannsjörg, Peter, Franziska, Mörl, Mario, Erdmann, Volker A, Lehrach, Hans, Konthur, Zoltán, Menger, Marcus, Arndt, Peter F, Glökler, Jörn

“…SELEX is an iterative process in which highly diverse synthetic nucleic acid libraries are selected over many rounds to finally identify aptamers with desired…”
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Design of antisense oligonucleotides stabilized by locked nucleic acids by Kurreck, Jens, Wyszko, Eliza, Gillen, Clemens, Erdmann, Volker A.

“…The design of antisense oligonucleotides containing locked nucleic acids (LNA) was optimized and compared to intensively studied DNA oligonucleotides,…”
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5SRNAdb: an information resource for 5S ribosomal RNAs by Szymanski, Maciej, Zielezinski, Andrzej, Barciszewski, Jan, Erdmann, Volker A, Karlowski, Wojciech M

“…Ribosomal 5S RNA (5S rRNA) is the ubiquitous RNA component found in the large subunit of ribosomes in all known organisms. Due to its small size, abundance and…”
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Local RNA Target Structure Influences siRNA Efficacy: Systematic Analysis of Intentionally Designed Binding Regions by Schubert, Steffen, Grünweller, Arnold, Erdmann, Volker A., Kurreck, Jens

“…Contradictory reports in the literature have emphasised either the sequence of small interfering RNAs (siRNA) or the structure of their target molecules to be…”
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Radiation and breast cancer: a review of current evidence by Ronckers, Cécile M, Erdmann, Christine A, Land, Charles E

“…This paper summarizes current knowledge on ionizing radiation-associated breast cancer in the context of established breast cancer risk factors, the radiation…”
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Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo by Christoph, Thomas, Grünweller, Arnold, Mika, Joanna, Schäfer, Martin K.-H., Wade, Erik J., Weihe, Eberhard, Erdmann, Volker A., Frank, Robert, Gillen, Clemens, Kurreck, Jens

“…RNA interference (RNAi) has proven to be a powerful technique to study the function of genes by producing knock-down phenotypes. Here, we report that…”
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Genetic Engineering of the Rock Inhabitant Knufia petricola Provides Insight Into the Biology of Extremotolerant Black Fungi by Erdmann, Eileen A., Nitsche, Sarah, Gorbushina, Anna A., Schumacher, Julia

“…Black microcolonial fungi (Ascomycetes from Arthonio-, Dothideo-, and Eurotiomycetes) are stress-tolerant and persistent dwellers of natural and anthropogenic…”
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Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′‐O‐methyl RNA, phosphorothioates and small interfering RNA by Grünweller, Arnold, Wyszko, Eliza, Bieber, Birgit, Jahnel, Ricarda, Erdmann, Volker A., Kurreck, Jens

“…Locked nucleic acids (LNAs) and double‐stranded small interfering RNAs (siRNAs) are rather new promising antisense molecules for cell culture and in vivo…”
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Reduced Time to Admit Emergency Department Patients to Inpatient Beds Using Outflow Barrier Analysis and Process Improvement by Erdmann, Marjorie A, Paramel, Ipe S, Marshall, Cari, LeHew, Karissa, Kee, Abigail, Soliman, Sarah, Monica Vuong, Monica, Sydney Spillane, Sydney, Joshua Baer, Joshua, Shania Do, Shania, Tiffany Jones, Tiffany, Derek McGuire, Derek

“…Because admitted emergency department (ED) patients waiting for an inpatient bed contribute to dangerous ED crowding, we conducted a patient flow investigation…”
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Evaluating the risk of patent infringement by means of semantic patent analysis: the case of DNA chips by Bergmann, Isumo, Butzke, Daniel, Walter, Lothar, Fuerste, Jens P., Moehrle, Martin G., Erdmann, Volker A.

“…In this paper, we are going to present a method for detecting the risks of patent infringement by evaluating similarities between patent documents on the basis…”
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Spiegelzymes® mirror-image hammerhead ribozymes and mirror-image DNAzymes, an alternative to siRNAs and microRNAs to cleave mRNAs in vivo? by Wyszko, Eliza, Mueller, Florian, Gabryelska, Marta, Bondzio, Angelika, Popenda, Mariusz, Barciszewski, Jan, Erdmann, Volker A

“…With the discovery of small non-coding RNA (ncRNA) molecules as regulators for cellular processes, it became intriguing to develop technologies by which these…”
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RNA cleaving ‘10‐23’ DNAzymes with enhanced stability and activity by Schubert, Steffen, Gül, Deniz C., Grunert, Hans‐Peter, Zeichhardt, Heinz, Erdmann, Volker A., Kurreck, Jens

“…‘10‐23’ DNAzymes can be used to cleave any target RNA in a sequence‐specific manner. For applications in vivo, they have to be stabilised against nucleolytic…”
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A new frontier for molecular medicine: Noncoding RNAs by Szymanski, Maciej, Barciszewska, Miroslawa Z., Erdmann, Volker A., Barciszewski, Jan

“…It is now becoming evident that the variety of noncoding RNA (ncRNA) molecules play important roles in many cellular processes and they are not just mere…”
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Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo by Erdmann, Andreas A., Gao, Zhan-Guo, Jung, Unsu, Foley, Jason, Borenstein, Todd, Jacobson, Kenneth A., Fowler, Daniel H.

“…To evaluate the direct effect of adenosine on cytokine-polarized effector T cells, murine type 1 helper T cells (Th1) and type 1 cytotoxic T lymphocytes (Tc1)…”
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Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice by Christoph, Thomas, Bahrenberg, Gregor, De Vry, Jean, Englberger, Werner, Erdmann, Volker A., Frech, Moritz, Kögel, Babette, Röhl, Thomas, Schiene, Klaus, Schröder, Wolfgang, Seibler, Jost, Kurreck, Jens

“…The function of the transient receptor potential vanilloid 1 (TRPV1) cation channel was analyzed with RNA interference technologies and compared to TRPV1…”
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crystal structure of an 'All Locked' nucleic acid duplex by Eichert, André, Behling, Katja, Betzel, Christian, Erdmann, Volker A, Fürste, Jens P, Förster, Charlotte

“…'Locked nucleic acids' (LNAs) are known to introduce enhanced bio- and thermostability into natural nucleic acids rendering them powerful tools for diagnostic…”
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