Search Results - "Erdemli, Gül"

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation by Carson, Cheryl, Raman, Pichai, Tullai, Jennifer, Xu, Lei, Henault, Martin, Thomas, Emily, Yeola, Sarita, Lao, Jianmin, McPate, Mark, Verkuyl, J Martin, Marsh, George, Sarber, Jason, Amaral, Adam, Bailey, Scott, Lubicka, Danuta, Pham, Helen, Miranda, Nicolette, Ding, Jian, Tang, Hai-Ming, Ju, Haisong, Tranter, Pamela, Ji, Nan, Krastel, Philipp, Jain, Rishi K, Schumacher, Andrew M, Loureiro, Joseph J, George, Elizabeth, Berellini, Giuliano, Ross, Nathan T, Bushell, Simon M, Erdemli, Gül, Solomon, Jonathan M

“…Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell…”
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Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin by Tran, Que-Tien, Pearlstein, Robert A., Williams, Sarah, Reilly, John, Krucker, Thomas, Erdemli, Gül

“…ABSTRACT The emergence of Gram‐negative “superbugs” exhibiting resistance to known antibacterials poses a major public health concern. Low molecular weight…”
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The translocation kinetics of antibiotics through porin OmpC: Insights from structure-based solvation mapping using WaterMap by Tran, Que-Tien, Williams, Sarah, Farid, Ramy, Erdemli, Gül, Pearlstein, Robert

“…Poor permeability of the lipopolysaccharide‐based outer membrane of Gram‐negative bacteria is compensated by the existence of protein channels (porins) that…”
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Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake by Asztely, Fredrik, Erdemli, Gül, Kullmann, Dimitri M.

“…At excitatory synapses on CA1 pyramidal cells of the hippocampus, a larger quantal content is sensed by N-methyl-D-aspartic acid receptors (NMDARs) than by…”
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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation by Erdemli, Gül, Kim, Albert M, Ju, Haisong, Springer, Clayton, Penland, Robert C, Hoffmann, Peter K

“…The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced…”
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LTP of AMPA and NMDA Receptor–Mediated Signals: Evidence for Presynaptic Expression and Extrasynaptic Glutamate Spill-Over by Kullmann, Dimitri M, Erdemli, Gül, Asztély, Fredrik

“…We have addressed the expression of long-term potentiation (LTP) in hippocampal CA1 by comparing AMPA and NMDA receptor–(AMPAR- and NMDAR-) mediated…”
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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm by Fermini, Bernard, Hancox, Jules C, Abi-Gerges, Najah, Bridgland-Taylor, Matthew, Chaudhary, Khuram W, Colatsky, Thomas, Correll, Krystle, Crumb, William, Damiano, Bruce, Erdemli, Gul, Gintant, Gary, Imredy, John, Koerner, John, Kramer, James, Levesque, Paul, Li, Zhihua, Lindqvist, Anders, Obejero-Paz, Carlos A, Rampe, David, Sawada, Kohei, Strauss, David G, Vandenberg, Jamie I

“…For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce QT interval prolongation and Torsades de Pointes (TdP) arrhythmia…”
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Non-uniform distribution of mitochondria in pancreatic acinar cells by Johnson, Paul R, Dolman, Nick J, Pope, Marion, Vaillant, Camille, Petersen, Ole H, Tepikin, Alexei V, Erdemli, Gül

“…The distribution of mitochondria in pancreatic acinar cells was investigated using confocal fluorescence microscopy and transmission electron microscopy (EM)…”
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Regulatory considerations for developing remote measurement technologies for Alzheimer’s disease research by Erdemli, Gül, Grammatikopoulou, Margarita, Wagner, Bertil, Vairavan, Srinivasan, Curcic, Jelena, Aarsland, Dag, Wittenberg, Gayle, Nikolopoulos, Spiros, Muurling, Marijn, Froehlich, Holger, de Boer, Casper, Shanbhag, Niraj M., Nies, Vera J. M., Coello, Neva, Gove, Dianne, Diaz, Ana, Foy, Suzanne, Dartee, Wim, Brem, Anna-Katharine

“…The Remote Assessment of Disease and Relapse – Alzheimer’s Disease (RADAR-AD) consortium evaluated remote measurement technologies (RMTs) for assessing…”
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Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation by Pearlstein, Robert A, MacCannell, K Andrew, Erdemli, Gül, Yeola, Sarita, Helmlinger, Gabriel, Hu, Qi-Ying, Farid, Ramy, Egan, William, Whitebread, Steven, Springer, Clayton, Beck, Jeremy, Wang, Hao-Ran, Maciejewski, Mateusz, Urban, Laszlo, Duca, José S

“…Blockade of the hERG potassium channel prolongs the ventricular action potential (AP) and QT interval, and triggers early after depolarizations (EADs) and…”
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Digital endpoints in clinical trials of Alzheimer's disease and other neurodegenerative diseases: challenges and opportunities by Brem, Anna-Katharine, Kuruppu, Sajini, de Boer, Casper, Muurling, Marijn, Diaz-Ponce, Ana, Gove, Dianne, Curcic, Jelena, Pilotto, Andrea, Ng, Wan-Fai, Cummins, Nicholas, Malzbender, Kristina, Nies, Vera J M, Erdemli, Gul, Graeber, Johanna, Narayan, Vaibhav A, Rochester, Lynn, Maetzler, Walter, Aarsland, Dag

“…Alzheimer's disease (AD) and other neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's disease (HD) are associated with progressive…”
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Response of Thalamocortical Neurons to Hypoxia: A Whole-Cell Patch-Clamp Study by Erdemli, Gul, Crunelli, Vincenzo

“…The effect of hypoxia (3-4 min of 95% N2, 5% CO2) on thalamocortical (TC) neurons was investigated using the whole-cell patch-clamp technique in rat dorsal…”
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Calcium-Dependent Enzyme Activation and Vacuole Formation in the Apical Granular Region of Pancreatic Acinar Cells by Raraty, Michael, Ward, Jeremy, Erdemli, Gul, Vaillant, Camille, Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.

“…The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen granules in the apical pole. Ca2+signals elicited by acetylcholine or…”
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Effects of cerebral ischemia on N-methyl-D-aspartate and dihydropyridine-sensitive calcium currents. An electrophysiological study in the rat hippocampus in situ by Dalkara, T, Ayata, C, Demirci, M, Erdemli, G, Onur, R

“…During cerebral ischemia, both promoting and limiting factors are present for activation of the N-methyl-D-aspartate (NMDA) receptor ion channel and the…”
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Description of the Method for Evaluating Digital Endpoints in Alzheimer Disease Study: Protocol for an Exploratory, Cross-sectional Study by Curcic, Jelena, Vallejo, Vanessa, Sorinas, Jennifer, Sverdlov, Oleksandr, Praestgaard, Jens, Piksa, Mateusz, Deurinck, Mark, Erdemli, Gul, Bügler, Maximilian, Tarnanas, Ioannis, Taptiklis, Nick, Cormack, Francesca, Anker, Rebekka, Massé, Fabien, Souillard-Mandar, William, Intrator, Nathan, Molcho, Lior, Madero, Erica, Bott, Nicholas, Chambers, Mieko, Tamory, Josef, Shulz, Matias, Fernandez, Gerardo, Simpson, William, Robin, Jessica, Snædal, Jón G, Cha, Jang-Ho, Hannesdottir, Kristin

“…More sensitive and less burdensome efficacy end points are urgently needed to improve the effectiveness of clinical drug development for Alzheimer disease…”
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On the Action of the Anti-Absence Drug Ethosuximide in the Rat and Cat Thalamus by Leresche, Nathalie, Parri, H. Rheinallt, Erdemli, Gul, Guyon, Alice, Turner, Jonathan P, Williams, Stephen R, Asprodini, Eftihia, Crunelli, Vincenzo

“…The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro…”
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Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin: Carbapenem Structure-Translocation Kinetics Through OmpC by Tran, Que-Tien, Pearlstein, Robert A., Williams, Sarah, Reilly, John, Krucker, Thomas, Erdemli, Gül

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Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system by Cao, Xueying, Lee, Yan Tony, Holmqvist, Mats, Lin, Yingxin, Ni, Yucheng, Mikhailov, Dmitri, Zhang, Haiyan, Hogan, Christopher, Zhou, Liping, Lu, Qiang, Digan, Mary Ellen, Urban, Laszlo, Erdemli, Gül

“…The normal electrophysiologic behavior of the heart is determined by the integrated activity of specific cardiac ionic currents. Mutations in genes encoding…”
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Assay Development and Validation for the Muscle Nicotinic Receptor Using the Qpatch HTX™ Automated Patch Clamp System by Lee, Yan T., Cao, Xueying, Holmqvist, Mats, Erdemli, Gül

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IonFlux: a microfluidic patch clamp system evaluated with human Ether-à-go-go related gene channel physiology and pharmacology by Golden, Andrew P, Li, Nianzhen, Chen, Qin, Lee, Tony, Nevill, Tanner, Cao, Xueying, Johnson, Juliette, Erdemli, Gül, Ionescu-Zanetti, Cristian, Urban, Laszlo, Holmqvist, Mats

“…Ion channel assays are essential in drug discovery, not only for identifying promising new clinical compounds, but also for minimizing the likelihood of…”
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