Search Results - "Erdemli, G"

Ion channel drug discovery: challenges and future directions by Wickenden, A, Priest, B, Erdemli, G

“…Ion channels are targets of many therapeutically useful agents, and worldwide sales of ion channel-targeted drugs are estimated to be approximately US$12…”
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Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells by Voronina, S., Sukhomlin, T., Johnson, P. R., Erdemli, G., Petersen, O. H., Tepikin, A.

“…Relationships between calcium signals and NADH responses were investigated in pancreatic acinar cells stimulated with calcium-releasing secretagogues…”
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Potassium Conductance Causing Hyperpolarization of CA1 Hippocampal Neurons During Hypoxia by Erdemli, G, Xu, Y. Z, Krnjevic, K

“…G. Erdemli , Y. Z. Xu , and K. Krnjevi Anaesthesia Research Department, McGill University, Montreal, Quebec H3G 1Y6, Canada Erdemli, G., Y. Z. Xu, and…”
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Non-uniform distribution of mitochondria in pancreatic acinar cells by Johnson, Paul R, Dolman, Nick J, Pope, Marion, Vaillant, Camille, Petersen, Ole H, Tepikin, Alexei V, Erdemli, Gül

“…The distribution of mitochondria in pancreatic acinar cells was investigated using confocal fluorescence microscopy and transmission electron microscopy (EM)…”
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Role of mitochondria in Ca(2+) homeostasis of mouse pancreatic acinar cells by Johnson, P R, Tepikin, A V, Erdemli, G

“…The effects of mitochondrial Ca(2+) uptake on cytosolic Ca(2+) concentration ([Ca(2+)](c)) were investigated in mouse pancreatic acinar cells using cytosolic…”
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P.3.d.022 Org 26576, a novel positive allosteric modulator, potentiates AMPA receptor responses in hippocampal neurones by Erdemli, G, Smith, L.H, Sammons, M, Jeggo, R, Shahid, M

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Release of monoamines and nitric oxide is involved in the modulation of hyperpolarization-activated inward current during acute thalamic hypoxia by Erdemli, G., Crunelli, V.

“…Using slices of the dorsal lateral geniculate nucleus, it has been shown that, in the presence of excitatory and inhibitory amino acid antagonists, brief…”
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Nitric oxide tonically depresses a voltage- and Ca-dependent outward current in hippocampal slices by Erdemli, G., Krnjević, K.

“…In whole-cell recordings from CAI neurons, net outward currents (at ca. −20 mV, from V H ca. −50 mV) were 40–50% depressed by sodium nitroprusside (100–500 μM)…”
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Is activation of metabotropic glutamate receptors responsible for acute hypoxic changes in hippocampal neurons? by Erdemli, G., Krnjević, K.

“…In whole-cell recordings from CAI neurons in slices from rats, the mGLUR agonist (±)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD; 10 μM) had a…”
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Actions of cromakalim on outward currents of CA1 neurones in hippocampal slices by Erdemli, G., Krnjevic, K.

“…1 Membrane effects of cromakalim (Crom; 50–300 μm) were examined in CA1 neurones recorded mainly by intracellular, single‐electrode voltage‐clamping in slices…”
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Actions of diazoxide on CA1 neurons in hippocampal slices from rats by Erdemli, G, Krnjević, K

“…Membrane effects of diazoxide (DZX) were examined in CA1 pyramidal neurons, mainly by whole-cell recording in slices kept at 33 degrees C (from Sprague-Dawley…”
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Digital endpoints in clinical trials of Alzheimer's disease and other neurodegenerative diseases: challenges and opportunities by Brem, Anna-Katharine, Kuruppu, Sajini, de Boer, Casper, Muurling, Marijn, Diaz-Ponce, Ana, Gove, Dianne, Curcic, Jelena, Pilotto, Andrea, Ng, Wan-Fai, Cummins, Nicholas, Malzbender, Kristina, Nies, Vera J M, Erdemli, Gul, Graeber, Johanna, Narayan, Vaibhav A, Rochester, Lynn, Maetzler, Walter, Aarsland, Dag

“…Alzheimer's disease (AD) and other neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's disease (HD) are associated with progressive…”
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Nitric oxide may be a mediator of effects of prolonged but not brief anoxia in CA1 neurons in slices by Zhu, P.J., Erdemli, G.

“…As a known vasodilator, nitric oxide (NO) probably acts by hyperpolarizing smooth muscle by increasing K conductance (G K). Therefore NO could mediate the…”
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Tetanic LTP in guinea pig CA1 is associated with an increase in the NMDA receptor-mediated component of EPSCs and in the rate of depression by MK-801 by Erdemli, G, Kullmann, DM

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Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport by Park, Myoung Kyu, Ashby, Michael C., Erdemli, Gul, Petersen, Ole H., Tepikin, Alexei V.

“…We have identified three distinct groups of mitochondria in normal living pancreatic acinar cells, located (i) in the peripheral basolateral region close to…”
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Calcium-Dependent Enzyme Activation and Vacuole Formation in the Apical Granular Region of Pancreatic Acinar Cells by Raraty, Michael, Ward, Jeremy, Erdemli, Gul, Vaillant, Camille, Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.

“…The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen granules in the apical pole. Ca2+signals elicited by acetylcholine or…”
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Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake by Asztely, Fredrik, Erdemli, Gül, Kullmann, Dimitri M.

“…At excitatory synapses on CA1 pyramidal cells of the hippocampus, a larger quantal content is sensed by N-methyl-D-aspartic acid receptors (NMDARs) than by…”
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Electrophysiological evidence for activation of NMDA receptors and its antagonism by MK-801 in cerebral ischemia by Dalkara, T, Tan, E, Erdemli, G, Onur, R, Zileli, T

“…We studied the effects of iontophoretically administered MK-801 (50-150 nA) on ischemic changes on the CA1 hippocampal field potential. Twenty rats under…”
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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation by Erdemli, Gül, Kim, Albert M, Ju, Haisong, Springer, Clayton, Penland, Robert C, Hoffmann, Peter K

“…The human cardiac sodium channel (hNav1.5, encoded by the SCN5A gene) is critical for action potential generation and propagation in the heart. Drug-induced…”
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LTP of AMPA and NMDA Receptor–Mediated Signals: Evidence for Presynaptic Expression and Extrasynaptic Glutamate Spill-Over by Kullmann, Dimitri M, Erdemli, Gül, Asztély, Fredrik

“…We have addressed the expression of long-term potentiation (LTP) in hippocampal CA1 by comparing AMPA and NMDA receptor–(AMPAR- and NMDAR-) mediated…”
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