Supression of cardiac parasympathetic functions in patients with right hemispheric stroke

Supression of cardiac parasympathetic functions in patients with right hemispheric stroke

Objectives: The aim of this study was to investigate the relationship between sympathetic and cardiac parasympathetic function and the side of the lesion in stroke patients. Methods: Thirty‐two patients with stroke and 29 healthy age‐matched control subjects were studied. Sympathetic skin responses...

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Bibliographic Details
Published in:European journal of neurology Vol. 6; no. 6; pp. 685 - 690
Main Authors: Erciyas, Ali Haydar, Topalkara, Kamil, Topaktas, Suat, Akyüz, Aytekin, Dener, Sefik
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Science Ltd 01-11-1999
Subjects:
Adult
Aged
Aged, 80 and over
autonomic functions
Brain - pathology
Brain - physiopathology
Electrocardiography
Female
Functional Laterality - physiology
Heart - innervation
Heart - physiopathology
Humans
Male
Middle Aged
Parasympathetic Nervous System - physiopathology
RR interval variation
stroke
Stroke - pathology
Stroke - physiopathology
sympathetic skin response
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Summary:Objectives: The aim of this study was to investigate the relationship between sympathetic and cardiac parasympathetic function and the side of the lesion in stroke patients. Methods: Thirty‐two patients with stroke and 29 healthy age‐matched control subjects were studied. Sympathetic skin responses (SSR) and RR interval variations (RRIV) during rest and deep breathing were recorded for the assessment of sympathetic and vagal parasympathetic function, respectively. Results: The mean SSR amplitude values in patients compared with controls were 337 ± 244 versus 1897 ± 848 (P < 0.0001) for right hemispheric lesions and 466 ± 398 versus 1873 ± 843 (P < 0.0001) for left hemispheric lesions. The mean SSR latencies in patients compared with controls were 1526 ± 163 versus 1395 ± 109 (P < 0.05) for right hemispheric lesions and 1490 ± 125 versus 1423 ± 112 (P < 0.05) for left hemispheric lesions. RRIV (during deep breathing)/RRIV (at rest) ratios in patients compared with controls were 1.20 ± 0.25 versus 1.84 ± 0.52 (P < 0.0001), and 1.55 ± 0.88 versus 1.84 ± 0.52 (P < 0.05) for right and left hemispheric lesions, respectively. Conclusion: Supression of vagal parasympathetic activity was more apparent in stroke patients with right hemispheric lesions in our series. Therefore, the right hemisphere seems to have a greater effect upon parasympathetic activity.
Bibliography:istex:6CD409C7B226A4D272DC4E0C7B7B531CC919C0A2
ark:/67375/WNG-0F53H3DB-4
ArticleID:ENEENE66_0685
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1351-5101
1468-1331
DOI:10.1046/j.1468-1331.1999.660685.x