In vivo biometric evaluation of Schlemm's canal with spectral‐domain optical coherence tomography in pseuduexfoliation glaucoma

Purpose To perform in vivo imaging of the Schlemm's canal (SC) with anterior segment spectral‐domain optical coherence tomography [AS‐spectral‐domain (SD)‐OCT] and also to measure its biometric parameters including the SC length and SC area in patients with pseudoexfoliation (PEX) glaucoma. Met...

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Bibliographic Details
Published in:	Acta ophthalmologica (Oxford, England) Vol. 94; no. 8; pp. e688 - e692
Main Authors:	Imamoglu, Serhat, Sevim, Mehmet S., Alpogan, Oksan, Ercalik, Nimet Y., Kumral, Esra Turkseven, Pekel, Gokhan, Bardak, Handan
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-12-2016
Subjects:	Aged Biometrics Biometry Exfoliation Syndrome - diagnosis Female Glaucoma Glaucoma, Open-Angle - diagnosis Humans Intraocular Pressure - physiology Limbus Corneae - diagnostic imaging Limbus Corneae - pathology Male Medical imaging Middle Aged Observer Variation OCT Ophthalmology Optical Coherence Tomography pseudoexfoliation Schlemm's canal Sclera - diagnostic imaging Sclera - pathology Tomography Tomography, Optical Coherence Tonometry, Ocular OCT pseudoexfoliation Schlemm's canal glaucoma
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Summary:	Purpose To perform in vivo imaging of the Schlemm's canal (SC) with anterior segment spectral‐domain optical coherence tomography [AS‐spectral‐domain (SD)‐OCT] and also to measure its biometric parameters including the SC length and SC area in patients with pseudoexfoliation (PEX) glaucoma. Methods Forty‐one consecutive patients with PEX glaucoma and 41 age‐ and sex‐matched normal subjects were enrolled. All subjects underwent imaging with SD‐OCT. The SC length and SC area were examined in the temporal sections and measured with customized software. Results The percentages of the temporal sections in which SC was observable were similar between the two groups. Mean SC length was found significantly shorter, and mean SC area was found significantly smaller in patients with PEX glaucoma than in controls (p = 0.044 and p = 0.036, respectively). Mean intra‐ocular pressure (IOP) values were also similar between two groups. No significant correlations were found between SC measurements and IOP. Conclusions Anterior segment spectral‐domain optical coherence tomography offers non‐invasive, in vivo measurement of the SC, and it could be used for investigating the SC changes in patients with PEX glaucoma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1755-375X 1755-3768
DOI:	10.1111/aos.13080