Search Results - "Erbs, P"

Vectorized gene therapy of liver tumors: proof-of-concept of TG4023 (MVA-FCU1) in combination with flucytosine by Husseini, F., Delord, J.-P., Fournel-Federico, C., Guitton, J., Erbs, P., Homerin, M., Halluard, C., Jemming, C., Orange, C., Limacher, J.-M., Kurtz, J.-E.

“…TG4023 is a modified vaccinia virus Ankara (MVA) containing the yeast-originated transgene FCU1, expressing cytosine deaminase and uracil…”
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Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes by Heinrich, B, Klein, J, Delic, M, Goepfert, K, Engel, V, Geberzahn, L, Lusky, M, Erbs, P, Preville, X, Moehler, M

“…Oncolytic virotherapy is an emerging immunotherapeutic modality for cancer treatment. Oncolytic viruses with genetic modifications can further enhance the…”
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Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus by Foloppe, J, Kintz, J, Futin, N, Findeli, A, Cordier, P, Schlesinger, Y, Hoffmann, C, Tosch, C, Balloul, J-M, Erbs, P

“…We have generated a thymidine kinase gene-deleted vaccinia virus (VV) (Copenhagen strain) that expressed the fusion suicide gene FCU1 derived from the yeast…”
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Modified vaccinia virus Ankara as a vector for suicide gene therapy by Erbs, P, Findeli, A, Kintz, J, Cordier, P, Hoffmann, C, Geist, M, Balloul, J-M

“…Modified vaccinia virus Ankara (MVA) has been used successfully to express various antigens for the development of vaccines. Here we show that MVA can also be…”
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Targeting of adenovirus vectors carrying a tumor cell-specific peptide: in vitro and in vivo studies by Rittner, K, Schreiber, V, Erbs, P, Lusky, M

“…Previously, we have identified a tumor cell-specific peptide, HEW, by panning of phage display libraries on the human colorectal cancer cell line WiDr. In this…”
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Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy by Tosch, C, Geist, M, Ledoux, C, Ziller-Remi, C, Paul, S, Erbs, P, Corvaia, N, Von Hoegen, P, Balloul, J-M, Haegel, H

“…The delivery of stimulatory signals to dendritic cells (DCs) in the tumor microenvironment could be an effective means to break tumor-induced tolerance. The…”
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New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism by Kurtz, J.E, Exinger, F, Erbs, P, Jund, R

“…Cytidine metabolism in the yeast Saccharomyces cerevisiae was analyzed by genetic and biochemical approaches. Disruption of a unique ORF (Genbank accession No…”
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486P Bioavailability and activity of oncolytic virus TG6002 after intravenous administration in patients with advanced gastrointestinal carcinomas by Cassier, P.A., Bendjama, K., Garcia, V. Moreno, De Speville Uribe, B. Doger, Calvo, E., de Miguel, M.J., Jungels, C., Erbs, P., Carpentier, D., Sadoun, A.

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392P Updated data of biodistribution and activity of oncolytic virus TG6002 after intravenous administration in patients with advanced gastrointestinal carcinomas by Moreno Garcia, V., Cassier, P.A., Doger de Spéville, B., Calvo, E., De Miguel, M.J., Garcia-Carbonero, R., Gomez-Roca, C.A., Jungels, C., P. Erbs, Sainte-Croix, S., Sadoun, A., Bendjama, K.

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Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans by Erbs, P, Exinger, F, Jund, R. (Hospices Civils, Strasbourg (France). Inst. de Recherche contre les Cancers de l'Appareil Digestif (IRCAD))

“…By functional complementation of a fcy1 null mutant of Saccharomyces cerevisiae, we have cloned and characterized the FCY1 gene, encoding cytosine deaminase in…”
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Ultrasound-mediated cavitation does not decrease the activity of small molecule, antibody or viral-based medicines by Myers, Rachel, Grundy, Megan, Rowe, Cliff, Coviello, Christian M, Bau, Luca, Erbs, Philippe, Foloppe, Johann, Balloul, Jean-Marc, Story, Colin, Coussios, Constantin C, Carlisle, Robert

“…The treatment of cancer using nanomedicines is limited by the poor penetration of these potentially powerful agents into and throughout solid tumors…”
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In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene by ERBS, P, REGULIER, E, KINTZ, J, LEROY, P, POITEVIN, Y, EXINGER, F, JUND, R, MEHTALI, M

“…Direct transfer of prodrug activation systems into tumors was demonstrated to be an attractive method for the selective in vivo elimination of tumor cells…”
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Selectivity and efficiency of late transgene expression by transcriptionally targeted oncolytic adenoviruses are dependent on the transgene insertion strategy by Quirin, Christina, Rohmer, Stanimira, Fernández-Ulibarri, Inés, Behr, Michael, Hesse, Andrea, Engelhardt, Sarah, Erbs, Philippe, Enk, Alexander H, Nettelbeck, Dirk M

“…Key challenges facing cancer therapy are the development of tumor-specific drugs and potent multimodal regimens. Oncolytic adenoviruses possess the potential…”
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Identification of a proacrosin precursor in the cell-free translation of boar testicular poly(A)+ -mRNA by Yi, L.S.H. (Washington University School of Medicine, St. Louis, MO), Erbs, P.A, Willand, J.L, Polakoski, K.L

“…A cell-free translation system was used to determine the molecular mass of the protein component of precursor(s) to boar proacrosin. Poly(A)+-mRNA was…”
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Dual SPECT/MR imaging in small animal by Breton, E., Choquet, P., Goetz, C., Kintz, J., Erbs, P., Rooke, R., Constantinesco, A.

“…To demonstrate the feasibility of SPECT/MRI in small animal using a dual device. A small animal pinhole camera (1.5 mm in diameter) coupled together with a…”
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Constitutive activation of the androgen receptor by a point mutation in the hinge region: A new mechanism for androgen‐independent growth in prostate cancer by Céraline, Jocelyn, Cruchant, Marion D., Erdmann, Eva, Erbs, Philippe, Kurtz, Jean‐Emmanuel, Duclos, Brigitte, Jacqmin, Didier, Chopin, Dominique, Bergerat, Jean‐Pierre

“…Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in…”
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The URH1 uridine ribohydrolase of Saccharomyces cerevisiae by Kurtz, Jean-Emmanuel, Exinger, Françoise, Erbs, Philippe, Jund, Richard

“…In the yeast Saccharomyces cerevisiae, uridine ribohydrolase activity is important for recycling, via the salvage pathway, pyrimidine deoxy- and…”
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R90: Étude d’un virus myxomateux optimisé pour la virothérapie anticancéreuse chez l’Homme by Gretillat, M., Erbs, P., Camus, C., Gelfi, J., Bertagnoli, S.

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Cancer immunotherapy by direct in vivo transfer of immunomodulatory genes by Leroy, P., Slos, P., Homann, H., Erbs, P., Poitevin, Y., Regulier, E., Colonna, F.Q., Devauchelle, P., Roth, C., Pavirani, A., Mehtali, M.

“…MHC-class I-positive cells expose on their surface thousands of self peptides derived from endogenous cellular or viral proteins, which constitute antigen…”
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A yeast-based functional assay for the detection of the mutant androgen receptor in prostate cancer by CERALINE, Jocelyn, ERDMANN, Eva, ERBS, Philippe, DESLANDRES-CRUCHANT, Marion, JACQMIN, Didier, DUCLOS, Brigitte, KLEIN-SOYER, Claudine, DUFOUR, Patrick, BCRGERAT, Jean-Pierre

“…Mutations in the ligand-binding domain of the human androgen receptor (AR) figure among the ways used by prostate adenocarcinoma (PCa) cells to escape androgen…”
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