Search Results - "Erb, H H H"

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer by Erb, Holger H H, Bodenbender, Julia, Handle, Florian, Diehl, Tamara, Donix, Lukas, Tsaur, Igor, Gleave, Martin, Haferkamp, Axel, Huber, Johannes, Fuessel, Susanne, Juengel, Eva, Culig, Zoran, Thomas, Christian

“…Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen…”
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The impact of androgen-induced translation in modulating androgen receptor activity by Israel, Justus S, Marcelin, Laura-Maria, Mehralivand, Sherif, Scholze, Jana, Hofmann, Jörg, Stope, Matthias B, Puhr, Martin, Thomas, Christian, Erb, Holger H. H

“…Abstract Introduction Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives…”
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New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium by Mehralivand, Sherif, Thomas, Christian, Puhr, Martin, Claessens, Frank, van de Merbel, Arjanneke F, Dubrovska, Anna, Jenster, Guido, Bernemann, Christof, Sommer, Ulrich, Erb, Holger H H

“…The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate…”
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Comprehensive Evaluation of Multiple Approaches Targeting ABCB1 to Resensitize Docetaxel-Resistant Prostate Cancer Cell Lines by Linke, Dinah, Donix, Lukas, Peitzsch, Claudia, Erb, Holger H H, Dubrovska, Anna, Pfeifer, Manuel, Thomas, Christian, Fuessel, Susanne, Erdmann, Kati

“…Docetaxel (DTX) is a mainstay in the treatment of metastatic prostate cancer. Failure of DTX therapy is often associated with multidrug resistance caused by…”
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The phosphorus legacy offers opportunities for agro-ecological transition (France 1850-2075) by Le Noë, J, Roux, N, Billen, G, Gingrich, S, Erb, K -H., Krausmann, F, Thieu, V, Silvestre, M, Garnier, J

“…Management of the non-renewable resource phosphorus (P) is critical to agricultural sustainability. The global P cycle is currently disturbed beyond planetary…”
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Middle-range theories of land system change by Meyfroidt, P., Roy Chowdhury, R., de Bremond, A., Ellis, E.C., Erb, K.-H., Filatova, T., Garrett, R.D., Grove, J.M., Heinimann, A., Kuemmerle, T., Kull, C.A., Lambin, E.F., Landon, Y., le Polain de Waroux, Y., Messerli, P., Müller, D., Nielsen, J.Ø., Peterson, G.D., Rodriguez García, V., Schlüter, M., Turner, B.L., Verburg, P.H.

“…•Landsystem science produced many empirical results but lacks progress in theory.•We review theories on causes of changes in land use extent and intensity.•We…”
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Prostate Cancer's Silent Partners: Fibroblasts and Their Influence on Glutamine Metabolism Manipulation by Hönscheid, Pia V, Baretton, Gustavo B, Puhr, Martin, Siciliano, Tiziana, Israel, Justus S, Stope, Matthias B, Ebersbach, Celina, Beier, Alicia-Marie K, Thomas, Christian, Erb, Holger H H

“…Cancer-associated fibroblast (CAF)s in the tumour microenvironment (TME) modulate the extracellular matrix, interact with cancer cells, and facilitate…”
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Impact of Androgen Receptor Activity on Prostate-Specific Membrane Antigen Expression in Prostate Cancer Cells by Sommer, Ulrich, Siciliano, Tiziana, Ebersbach, Celina, Beier, Alicia-Marie K, Stope, Matthias B, Jöhrens, Korinna, Baretton, Gustavo B, Borkowetz, Angelika, Thomas, Christian, Erb, Holger H H

“…Prostate-specific membrane antigen (PSMA) is an essential molecular regulator of prostate cancer (PCa) progression coded by the gene. The PSMA protein has…”
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Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways by Oh, Su Jung, Erb, Holger H H, Hobisch, Alfred, Santer, Frédéric R, Culig, Zoran

“…Antihormonal and chemotherapy are standard treatments for nonorgan-confined prostate cancer. The effectivity of these therapies is limited and the development…”
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Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells by Vakhrusheva, Olesya, Erb, Holger H H, Bräunig, Vitus, Markowitsch, Sascha D, Schupp, Patricia, Baer, Patrick C, Slade, Kimberly Sue, Thomas, Anita, Tsaur, Igor, Puhr, Martin, Culig, Zoran, Cinatl, Jr, Jindrich, Michaelis, Martin, Efferth, Thomas, Haferkamp, Axel, Juengel, Eva

“…Novel therapeutic strategies are urgently needed for advanced metastatic prostate cancer (PCa). Phytochemicals used in Traditional Chinese Medicine seem to…”
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Quantification of uncertainties in global grazing systems assessment by Fetzel, T., Havlik, P., Herrero, M., Kaplan, J. O., Kastner, T., Kroisleitner, C., Rolinski, S., Searchinger, T., Van Bodegom, P. M., Wirsenius, S., Erb, K.‐H.

“…Livestock systems play a key role in global sustainability challenges like food security and climate change, yet many unknowns and large uncertainties prevail…”
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Agroecological measures and circular economy strategies to ensure sufficient nitrogen for sustainable farming by Morais, T.G., Teixeira, R.F.M., Lauk, C., Theurl, M.C., Winiwarter, W., Mayer, A., Kaufmann, L., Haberl, H., Domingos, T., Erb, K.-H.

“…•Organic farming has low impact per unit area but is limited in nitrogen.•Dietary changes are important but insufficient to overcome nitrogen…”
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The Androgen Hormone-Induced Increase in Androgen Receptor Protein Expression Is Caused by the Autoinduction of the Androgen Receptor Translational Activity by Siciliano, Tiziana, Sommer, Ulrich, Beier, Alicia-Marie K., Stope, Matthias B., Borkowetz, Angelika, Thomas, Christian, Erb, Holger H. H.

“…The androgen receptor (AR) plays a central role in prostate, muscle, bone and adipose tissue. Moreover, dysregulated AR activity is a driving force in prostate…”
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Metabolic changes during prostate cancer development and progression by Beier, Alicia-Marie K., Puhr, Martin, Stope, Matthias B., Thomas, Christian, Erb, Holger H. H.

“…Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant modification of the tumour’s bioenergetics provides energy for tumour…”
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Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205 by Puhr, Martin, Hoefer, Julia, Schäfer, Georg, Erb, Holger H.H, Oh, Su Jung, Klocker, Helmut, Heidegger, Isabel, Neuwirt, Hannes, Culig, Zoran

“…Docetaxel is a standard chemotherapy for patients with metastatic prostate cancer. However, the response is rather limited and not all of the patients benefit…”
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Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts by Eigentler, Andrea, Handle, Florian, Schanung, Silvia, Degen, Antonia, Hackl, Hubert, Erb, Holger H. H., Fotakis, Georgios, Hoefer, Julia, Ploner, Christian, Jöhrer, Karin, Heidegger, Isabel, Pircher, Andreas, Klotz, Werner, Herold, Manfred, Schäfer, Georg, Culig, Zoran, Puhr, Martin

“…Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative, owing to the inevitable occurrence…”
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Upcycling food leftovers and grass resources through livestock: Impact of livestock system and productivity by van Hal, O., de Boer, I.J.M., Muller, A., de Vries, S., Erb, K.-H., Schader, C., Gerrits, W.J.J., van Zanten, H.H.E.

“…Consumption of animal-source food is criticised, among other reasons, for its relatively high environmental impact. It is, however, increasingly acknowledged…”
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Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer by Beier, Alicia-Marie K., Ebersbach, Celina, Siciliano, Tiziana, Scholze, Jana, Hofmann, Jörg, Hönscheid, Pia, Baretton, Gustavo B., Woods, Kevin, Guezguez, Borhane, Dubrovska, Anna, Markowitsch, Sascha D., Thomas, Christian, Puhr, Martin, Erb, Holger H. H.

“…Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable…”
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A Systematic Comparison of Antiandrogens Identifies Androgen Receptor Protein Stability as an Indicator for Treatment Response by Siciliano, Tiziana, Simons, Ingo H, Beier, Alicia-Marie K, Ebersbach, Celina, Aksoy, Cem, Seed, Robert I, Stope, Matthias B, Thomas, Christian, Erb, Holger H H

“…Antiandrogen therapy is a primary treatment for patients with metastasized prostate cancer. Whilst the biologic mechanisms of antiandrogens have been…”
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The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling by Nappo, G, Handle, F, Santer, F R, McNeill, R V, Seed, R I, Collins, A T, Morrone, G, Culig, Z, Maitland, N J, Erb, H H H

“…Interleukin-4 plays a critical role in the regulation of immune responses and has been detected at high levels in the tumour microenvironment of cancer…”
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