Search Results - "Eramo, Adriana"

L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients by Lo Cicero, Stefania, Castelli, Germana, Blaconà, Giovanna, Bruno, Sabina Maria, Sette, Giovanni, Pigliucci, Riccardo, Villella, Valeria Rachela, Esposito, Speranza, Zollo, Immacolata, Spadaro, Francesca, Maria, Ruggero De, Biffoni, Mauro, Cimino, Giuseppe, Amato, Felice, Lucarelli, Marco, Eramo, Adriana

“…Abstract Cystic fibrosis (CF) is caused by defects of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR-modulating drugs may overcome…”
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MicroRNAs Impair MET-Mediated Invasive Growth by MIGLIORE, Cristina, PETRELLI, Annalisa, GHISO, Elena, CORSO, Simona, CAPPARUCCIA, Lorena, ERAMO, Adriana, COMOGLIO, Paolo M, GIORDANO, Silvia

“…MicroRNAs (miRNA) are a recently identified class of noncoding, endogenous, small RNAs that regulate gene expression, mainly at the translational level. These…”
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Targeting Melanoma-Initiating Cells by Caffeine: In Silico and In Vitro Approaches by Tabolacci, Claudio, Cordella, Martina, Rossi, Stefania, Bonaccio, Marialaura, Eramo, Adriana, Mischiati, Carlo, Beninati, Simone, Iacoviello, Licia, Facchiano, Antonio, Facchiano, Francesco

“…The beneficial effects of coffee on human diseases are well documented, but the molecular mechanisms of its bioactive compounds on cancer are not completely…”
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Lipid Storage and Autophagy in Melanoma Cancer Cells by Giampietri, Claudia, Petrungaro, Simonetta, Cordella, Martina, Tabolacci, Claudio, Tomaipitinca, Luana, Facchiano, Antonio, Eramo, Adriana, Filippini, Antonio, Facchiano, Francesco, Ziparo, Elio

“…Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using…”
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A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice by De Angelis, Maria Laura, Francescangeli, Federica, Aricò, Eleonora, Verachi, Paola, Zucchetti, Massimo, Matteo, Cristina, Petricci, Elena, Pilozzi, Emanuela, Orienti, Isabella, Boe, Alessandra, Eramo, Adriana, Rossi, Rachele, Corati, Tiberio, Macchia, Daniele, Pacca, Anna Maria, Zeuner, Ann, Baiocchi, Marta

“…Abstract Background Prevention and treatment of metastatic breast cancer (BC) is an unmet clinical need. The retinoic acid derivative fenretinide (FeR) was…”
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Correction to: L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fbrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients by Lo Cicero, Stefania, Castelli, Germana, Blaconà, Giovanna, Bruno, Sabina Maria, Sette, Giovanni, Pigliucci, Riccardo, Villella, Valeria Rachela, Esposito, Speranza, Zollo, Immacolata, Spadaro, Francesca, De Maria, Ruggero, Biffoni, Mauro, Cimino, Giuseppe, Amato, Felice, Lucarelli, Marco, Eramo, Adriana

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Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma by Tafani, Marco, Di Vito, Maura, Frati, Alessandro, Pellegrini, Laura, De Santis, Elena, Sette, Giovanni, Eramo, Adriana, Sale, Patrizio, Mari, Emanuela, Santoro, Antonio, Raco, Antonino, Salvati, Maurizio, De Maria, Ruggero, Russo, Matteo A

“…Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate and breast carcinomas have been implicated in the progression toward cancer…”
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Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors by RUTELLA, Sergio, BONANNO, Giuseppina, NUTI, Marianna, PIERELL, Luca, TESTA, Ugo, SCAMBIA, Giovanni, FERRANDINA, Gabriella, PROCOLI, Annabella, MARIOTTI, Andrea, CORALLO, Maria, GRAZIA PRISCO, Maria, ERAMO, Adriana, NAPOLETANO, Chiara, GALLO, Daniela, PERILLO, Alessandro

“…Purpose: Cancer stem cells represent an attractive therapeutic target for tumor eradication. The present study aimed to determine whether CD133 expression may…”
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A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells by Orienti, Isabella, Salvati, Valentina, Sette, Giovanni, Zucchetti, Massimo, Bongiorno-Borbone, Lucilla, Peschiaroli, Angelo, Zolla, Lello, Francescangeli, Federica, Ferrari, Mariella, Matteo, Cristina, Bello, Ezia, Di Virgilio, Antonio, Falchi, Mario, De Angelis, Maria Laura, Baiocchi, Marta, Melino, Gerry, De Maria, Ruggero, Zeuner, Ann, Eramo, Adriana

“…An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly…”
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Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer by Del Bufalo, Donatella, Desideri, Marianna, De Luca, Teresa, Di Martile, Marta, Gabellini, Chiara, Monica, Valentina, Busso, Simone, Eramo, Adriana, De Maria, Ruggero, Milella, Michele, Trisciuoglio, Daniela

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Pemetrexed, a multi-target folate antagonist, has demonstrated…”
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Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide by Matteo, Cristina, Orienti, Isabella, Eramo, Adriana, Zeuner, Ann, Ferrari, Mariella, Passoni, Alice, Bagnati, Renzo, Ponzo, Marianna, Bello, Ezia, Zucchetti, Massimo, Frapolli, Roberta

“…We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumor distribution of fenretinide, a synthetic retinoid…”
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CRIPTO Is a Marker of Chemotherapy-Induced Stem Cell Expansion in Non-Small Cell Lung Cancer by Francescangeli, Federica, De Angelis, Maria Laura, Rossi, Rachele, Sette, Giovanni, Eramo, Adriana, Boe, Alessandra, Guardiola, Ombretta, Tang, Tao, Yu, Shi-Cang, Minchiotti, Gabriella, Zeuner, Ann

“…Chemotherapy is the mainstay for the treatment of non-small cell lung cancer (NSCLC). However, NSCLC cells are either intrinsically chemoresistant or rapidly…”
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Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models by Del Curatolo, Anais, Conciatori, Fabiana, Cesta Incani, Ursula, Bazzichetto, Chiara, Falcone, Italia, Corbo, Vincenzo, D'Agosto, Sabrina, Eramo, Adriana, Sette, Giovanni, Sperduti, Isabella, De Luca, Teresa, Marabese, Mirko, Shirasawa, Senji, De Maria, Ruggero, Scarpa, Aldo, Broggini, Massimo, Del Bufalo, Donatella, Cognetti, Francesco, Milella, Michele, Ciuffreda, Ludovica

“…Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure…”
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Ex Vivo Irradiation of Lung Cancer Stem Cells Identifies the Lowest Therapeutic Dose Needed for Tumor Growth Arrest and Mass Reduction In Vivo by Puglisi, Caterina, Giuffrida, Raffaella, Borzì, Giuseppina, Illari, Salvatore, Caronia, Francesco Paolo, Di Mattia, Paolo, Colarossi, Cristina, Ferini, Gianluca, Martorana, Emanuele, Sette, Giovanni, Eramo, Adriana, Lorico, Aurelio, Di Grazia, Alfio, Forte, Stefano

“…Radiotherapy represents a first-line treatment for many inoperable lung tumors. New technologies offer novel opportunities for the treatment of lung cancer…”
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Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma by Vellanki, Sri Hari Krishna, Grabrucker, Andreas, Liebau, Stefan, Proepper, Christian, Eramo, Adriana, Braun, Veit, Boeckers, Tobias, Debatin, Klaus-Michael, Fulda, Simone

“…Because evasion of apoptosis can cause radioresistance of glioblastoma, there is a need to design rational strategies that counter apoptosis resistance. In the…”
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EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential by Sette, Giovanni, Salvati, Valentina, Memeo, Lorenzo, Fecchi, Katia, Colarossi, Cristina, Di Matteo, Paola, Signore, Michele, Biffoni, Mauro, D'Andrea, Vito, De Antoni, Enrico, Canzonieri, Vincenzo, De Maria, Ruggero, Eramo, Adriana

“…Tumor cells with stem-like phenotype and properties, known as cancer stem cells (CSC), have been identified in most solid tumors and are presumed to be…”
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Resistance of papillary thyroid cancer stem cells to chemotherapy by GIUFFRIDA, RAFFAELLA, ADAMO, LUANA, IANNOLO, GIOACCHIN, VICARI, LUISA, GIUFFRIDA, DARIO, ERAMO, ADRIANA, GULISANO, MASSIMO, MEMEO, LORENZO, CONTICELLO, CONCETTA

“…Thyroid carcinoma is the most common endocrine neoplasm, with the highest mortality rate of all the endocrine cancers. Among the endocrine malignancies, ~80%…”
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The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms by Ciuffreda, Ludovica, Di Sanza, Cristina, Cesta Incani, Ursula, Eramo, Adriana, Desideri, Marianna, Biagioni, Francesca, Passeri, Daniela, Falcone, Italia, Sette, Giovanni, Bergamo, Paola, Anichini, Andrea, Sabapathy, Kanaga, McCubrey, James A., Ricciardi, Maria Rosaria, Tafuri, Agostino, Blandino, Giovanni, Orlandi, Augusto, De Maria, Ruggero, Cognetti, Francesco, Del Bufalo, Donatella, Milella, Michele

“…The mitogen-activated protein kinase (MAPK) and PI3K pathways are regulated by extensive crosstalk, occurring at different levels. In tumors, transactivation…”
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Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1 by De Maria, Ruggero, Zeuner, Ann, Eramo, Adriana, Domenichelli, Cristina, Bonci, Desiree, Grignani, Francesco, Srinivasula, Srinivasa M, Alnemri, Emad S, Testa, Ugo, Peschle, Cesare

“…The production of red blood cells follows the sequential formation of proerythroblasts and basophilic, polychromatophilic and orthochromatic erythroblasts, and…”
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CD95 death‐inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells by Eramo, Adriana, Sargiacomo, Massimo, Ricci‐Vitiani, Lucia, Todaro, Matilde, Stassi, Giorgio, Messina, Carlo G. M., Parolini, Isabella, Lotti, Fiorenza, Sette, Giovanni, Peschle, Cesare, De Maria, Ruggero

“…We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and activate caspase‐8. We found that…”
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