Search Results - "Eraly, S A"

Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models by Sweet, D.H., Eraly, S.A., Vaughn, D.A., Bush, K.T., Nigam, S.K.

“…Organic anion and cation transporters (OATs, OCTs, and OCTNs) mediate the proximal tubular secretion of numerous clinically important compounds, including…”
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Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements by Eraly, S A, Mellon, P L

“…We previously demonstrated that down-regulation of protein kinase C (PKC) by prolonged 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment leads to the…”
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Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters by Eraly, Satish A, Monte, Julio C, Nigam, Sanjay K

“…1 Department of Medicine, University of California, San Diego, La Jolla, California 92093-0693 2 Department of Pediatrics, University of California, San Diego,…”
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Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons by Wetsel, W C, Eraly, S A, Whyte, D B, Mellon, P L

“…As major signal transduction cascades, the protein kinase-A and -C (PKA and PKC) pathways have been implicated in the regulation of GnRH synthesis and…”
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The molecular pharmacology of organic anion transporters: from DNA to FDA? by Eraly, Satish A, Bush, Kevin T, Sampogna, Rosemary V, Bhatnagar, Vibha, Nigam, Sanjay K

“…Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a…”
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Oct-1 Binds Promoter Elements Required for Transcription of the GnRH Gene by Eraly, Satish A, Nelson, Shelley B, Huang, Karen M, Mellon, Pamela L

“…The GnRH gene is exclusively expressed in a discrete population of neurons in the hypothalamus. The promoter-proximal 173 bp of the rat GnRH gene are highly…”
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The GnRH promoter: Target of transcription factors, hormones, and signaling pathways by Nelson, S B, Eraly, S A, Mellon, P L

“…Gonadotropin-releasing hormone (GnRH) is essential for normal reproductive maturation and function. We present a review of the known mechanisms of hypothalamic…”
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A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons by Whyte, D B, Lawson, M A, Belsham, D D, Eraly, S A, Bond, C T, Adelman, J P, Mellon, P L

“…The molecular mechanisms specifying gene expression in individual neurons of the mammalian central nervous system have been difficult to study due to the…”
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Novel aspects of renal organic anion transporters by Eraly, Satish A, Blantz, Roland C, Bhatnagar, Vibha, Nigam, Sanjay K

“…PURPOSE OF REVIEWOrganic anion transporters, transmembrane proteins present in the renal proximal tubule, are a critical component of the human drug excretion…”
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Immortalized hypothalamic gonadotropin-releasing hormone neurons by Mellon, P L, Wetsel, W C, Windle, J J, Valença, M M, Goldsmith, P C, Whyte, D B, Eraly, S A, Negro-Vilar, A, Weiner, R I

“…The neuroendocrine hypothalamus has been intensively studied using whole animals and tissue slices. However, it has been difficult to approach questions at the…”
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Multiple organic anion transporters contribute to net renal excretion of uric acid by Eraly, Satish A, Vallon, Volker, Rieg, Timo, Gangoiti, Jon A, Wikoff, William R, Siuzdak, Gary, Barshop, Bruce A, Nigam, Sanjay K

“…1 Department of Medicine, University of California, San Diego 2 Department of Pharmacology, University of California, San Diego 4 Department of Pediatrics,…”
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Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice by Eraly, Satish A., Vallon, Volker, Vaughn, Duke A., Gangoiti, Jon A., Richter, Kerstin, Nagle, Megha, Monte, Julio C., Rieg, Timo, Truong, David M., Long, Jeffrey M., Barshop, Bruce A., Kaler, Gregory, Nigam, Sanjay K.

“…The “classical” organic anion secretory pathway of the renal proximal tubule is critical for the renal excretion of the prototypic organic anion,…”
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Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)] Rapid Communication by Xu, Gang, Bhatnagar, Vibha, Wen, G.E.N., Hamilton, Bruce A., Eraly, Satish A., Nigam, Sanjay K.

“…Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]…”
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Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa by Monte, Julio C., Nagle, Megha A., Eraly, Satish A., Nigam, Sanjay K.

“…The organic anion and cation transporters (OATs and OCTs) are a large family (SLC22) of transmembrane proteins that are able to transport a variety of…”
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Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions by Kaler, Gregory, Truong, David M., Sweeney, Derina E., Logan, Darren W., Nagle, Megha, Wu, Wei, Eraly, Satish A., Nigam, Sanjay K.

“…We have characterized the expression of organic anion transporter 6, Oat6 (slc22a20), in olfactory mucosa, as well as its interaction with several odorant…”
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Organic anion and cation transporters occur in pairs of similar and similarly expressed genes by Eraly, Satish A, Hamilton, Bruce A, Nigam, Sanjay K

“…Organic anion and cation transporters (OATs, OCTs, OCTNs, and ORCTLs), transmembrane proteins essential to renal xenobiotic excretion, are encoded by a group…”
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Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters by Eraly, Satish A, Nigam, Sanjay K

“…The molecular basis of the transport of organic ions (which include such medically important compounds as drugs, toxins, and metabolites) has been intensively…”
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Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis by Li, Zhixing, Stuart, Robert O, Eraly, Satish A, Gittes, George, Beier, David R, Nigam, Sanjay K

“…In a differential screen for genes that might be important in the regulation of epithelial morphogenesis, we identified a novel gene, Debt91 (differentially…”
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Hypothalamus-specific regulation of gonadotropin-releasing hormone gene expression by Lawson, M A, Whyte, D B, Eraly, S A, Mellon, P L

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