Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure

Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure

An enormous amount of data has been published in recent years demonstrating melatonin's defensive role against toxic free radicals. In the present study, we examined the role of melatonin as an antioxidant against the effect of continuous light exposure. Rats were divided into three groups. Con...

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Bibliographic Details
Published in:Cell biochemistry and function Vol. 19; no. 1; pp. 37 - 41
Main Authors: Baydaş, Giyasettin, Erçel, Ergul, Canatan, Halit, Dönder, Emir, Akyol, Ali
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-03-2001
Subjects:
Animals
Antioxidants - pharmacology
Brain - metabolism
Glutathione Peroxidase - metabolism
GSH-Px
Hydroxyl Radical - metabolism
Kidney - metabolism
Light
light exposure
Lipid Peroxidation
Liver - metabolism
Male
Malondialdehyde - blood
Malondialdehyde - metabolism
melatonin
Melatonin - pharmacology
Oxidative Stress - drug effects
Oxygen - metabolism
Pineal Gland - metabolism
Rats
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Summary:An enormous amount of data has been published in recent years demonstrating melatonin's defensive role against toxic free radicals. In the present study, we examined the role of melatonin as an antioxidant against the effect of continuous light exposure. Rats were divided into three groups. Control rats (group A) were kept under natural conditions whereas other group of rats (group B and C) were exposed to constant light for inhibition of melatonin secretion by the pineal gland. Group C rats also received melatonin via s.c. injection (1 mg kg− 1 body weight day− 1). At the end of experiment, all animals were sacrificied by decapitation, serum and tissue samples were removed for determination of malondialdehyde (MDA), a product of lipid peroxidation, conjugated dienes levels and glutathione peroxidase (GSH‐Px) activity levels. It was found that lipid peroxidation was increased in the rats which were exposed to constant light. Melatonin injection caused a decrease in lipid peroxidation, especially in the brain. In addition, melatonin application resulted in increased GSH‐Px activity, which has an antioxidant effect. Thus, melatonin is not only a direct scavenger of toxic radicals, but also stimulates the antioxidative enzyme GSH‐Px activity to detoxify hydroxyl radical produced by constant light exposure. Copyright © 2001 John Wiley & Sons, Ltd.
Bibliography:ArticleID:CBF897
istex:F9ED9718514B6533800CD1F91C74FF35E2D588ED
ark:/67375/WNG-1K5CCNGR-3
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.897