Search Results - "Er, Emrah"

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation by Mendoza, Michelle C., Er, E. Emrah, Blenis, John

“…The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the…”
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AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve by Er, Ekrem Emrah, Mendoza, Michelle C, Mackey, Ashley M, Rameh, Lucia E, Blenis, John

“…Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that controls cell proliferation, growth, survival, metabolism, and migration by…”
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ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex by Mendoza, Michelle C., Er, E. Emrah, Zhang, Wenjuan, Ballif, Bryan A., Elliott, Hunter L., Danuser, Gaudenz, Blenis, John

“…Cell movement begins with a leading edge protrusion, which is stabilized by nascent adhesions and retracted by mature adhesions. The ERK-MAPK (extracellular…”
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Mechanoregulation of Metastasis beyond the Matrix by Er, Ekrem Emrah, Tello-Lafoz, Maria, Huse, Morgan

“…Epithelial transformation and carcinogenesis are characterized by profound alterations in cell mechanics that significantly affect multiple steps of the…”
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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer by Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Er, Ekrem Emrah, Lopez-Soto, Alejandro, S. Jacob, Leni, Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R., Massagué, Joan

“…Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here…”
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Changes in cropland area in the United States and the role of CRP by Hendricks, Nathan P., Er, Emrah

“…•Estimates of cropland conversions differ by data source.•The Conservation Reserve Program (CRP) is the main driver of changes in cropland.•The U.S. government…”
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Abstract LT016: Mechanosurveillance eliminates disseminated cancer cells by sensing their mechanical compliance by Tello-Lafoz, Maria, Srpan, Katja, Hu, Jing, Romin, Yevgeniy, Calò, Annalisa, Hsu, Katharine C., Massagué, Joan, Huse, Morgan, Emrah Er, Ekrem

“…Metastatic dissemination of cancer cells to vital secondary organs pose a lifelong lethal threat unless they can successfully be eliminated by the immune…”
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Applications of Machine Learning to Agricultural Land Values: Prediction and Causal Inference by Er, Emrah

“…This dissertation focuses on the prediction of agricultural land values and the effects of water rights on land values using machine learning algorithms and…”
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Corrigendum: Carcinomaastrocyte gap junctions promote brain metastasis by cGAMP transfer by Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Emrah Er, Ekrem, Lopez-Soto, Alejandro, Jacob, Leni S, Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R, Massagu, Joan

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Correction: Corrigendum: Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer by Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Emrah Er, Ekrem, Lopez-Soto, Alejandro, Jacob, Leni S., Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R., Massagué, Joan

“…Nature 533, 493–498 (2016); doi:10.1038/nature18268 In this Article, Extended Data Figs 7d and 9a, presenting results obtained with the H2030-BrM3 cell line,…”
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Erratum: Corrigendum: Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer by Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Emrah Er, Ekrem, Lopez-Soto, Alejandro, Jacob, Leni S., Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R., Massagué, Joan

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Abstract SY23-02: Elevated cellular stiffness sensitizes metastatic cells to destruction by mechanosurveillance: The mechanical mode of immune surveillance by Er, Ekrem Emrah

“…Tumor evolution is coupled to profound biophysical changes in cancer cells and understanding how these changes impact metastasis can reveal novel therapeutic…”
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TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1 by Su, Jie, Morgani, Sophie M., David, Charles J., Wang, Qiong, Er, Ekrem Emrah, Huang, Yun-Han, Basnet, Harihar, Zou, Yilong, Shu, Weiping, Soni, Rajesh K., Hendrickson, Ronald C., Hadjantonakis, Anna-Katerina, Massagué, Joan

“…Epithelial-to-mesenchymal transitions (EMTs) are phenotypic plasticity processes that confer migratory and invasive properties to epithelial cells during…”
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Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization by Er, Ekrem Emrah, Valiente, Manuel, Ganesh, Karuna, Zou, Yilong, Agrawal, Saloni, Hu, Jing, Griscom, Bailey, Rosenblum, Marc, Boire, Adrienne, Brogi, Edi, Giancotti, Filippo G., Schachner, Melitta, Malladi, Srinivas, Massagué, Joan

“…Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the…”
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Photoacoustic imaging for investigating tumor hypoxia: a strategic assessment by Nasri, Deyana, Manwar, Rayyan, Kaushik, Ajeet, Er, Ekrem Emrah, Avanaki, Kamran

“…Hypoxia causes the expression of signaling molecules which regulate cell division, lead to angiogenesis, and further, in the tumor microenvironment, promote…”
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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer by Tello-Lafoz, Maria, Srpan, Katja, Sanchez, Elisa E., Hu, Jing, Remsik, Jan, Romin, Yevgeniy, Calò, Annalisa, Hoen, Douglas, Bhanot, Umeshkumar, Morris, Luc, Boire, Adrienne, Hsu, Katharine C., Massagué, Joan, Huse, Morgan, Er, Ekrem Emrah

“…Immune cells identify and destroy tumors by recognizing cellular traits indicative of oncogenic transformation. In this study, we found that myocardin-related…”
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Corrigendum: Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer by Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Emrah Er, Ekrem, Lopez-Soto, Alejandro, Jacob, Leni S, Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R, Massagué, Joan

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Abstract 209: Metastatic colonization in the perivascular niche: A mechanotransduction perspective by Er, Ekrem Emrah, Tello-Lafoz, Maria, Hu, Jing, Huse, Morgan, Massagué, Joan

“…Metastases are responsible for majority cancer related deaths. Disseminated tumor cells (DTCs) gain a diverse array of metastatic traits in order to adapt to…”
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L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer by Ganesh, Karuna, Basnet, Harihar, Kaygusuz, Yasemin, Laughney, Ashley M, He, Lan, Sharma, Roshan, O'Rourke, Kevin P, Reuter, Vincent P, Huang, Yun-Han, Turkekul, Mesruh, Er, Ekrem Emrah, Masilionis, Ignas, Manova-Todorova, Katia, Weiser, Martin R, Saltz, Leonard B, Garcia-Aguilar, Julio, Koche, Richard, Lowe, Scott W, Pe'er, Dana, Shia, Jinru, Massagué, Joan

“…Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and relationship to primary-tumor-initiating stem cells are not…”
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Abstract 2825: Mechanosurveillance by immunity targets mechanical compliance of metastatic cells by Tello-Lafoz, Maria, Srpan, Katja, Hu, Jing, Romin, Yevgeniy, Calo, Annalisa, Hsu, Katharine C., Massagué, Joan, Huse, Morgan, Er, Ekrem Emrah

“…Metastatic dissemination of cancer cells to vital secondary organs pose a lifelong lethal threat unless they can successfully be eliminated by the immune…”
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