Search Results - "Epstein, David L."

A Global Model for Forecasting Political Instability by Goldstone, Jack A., Bates, Robert H., Epstein, David L., Gurr, Ted Robert, Lustik, Michael B., Marshall, Monty G., Ulfelder, Jay, Woodward, Mark

“…Examining onsets of political instability in countries worldwide from 1955 to 2003, we develop a model that distinguishes countries that experienced…”
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Democratic Transitions by Epstein, David L., Bates, Robert, Goldstone, Jack, Kristensen, Ida, O'Halloran, Sharyn

“…Przeworski et al. (2000) challenge the key hypothesis in modernization theory: political regimes do not transition to democracy as per capita incomes rise,…”
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Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells by Li, Guorong, Luna, Coralia, Qiu, Jianming, Epstein, David L, Gonzalez, Pedro

“…To investigate the biological functions of miR-204 in human trabecular meshwork (HTM) cells. Changes in gene expression induced by miR-204 in HTM cells were…”
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Alterations in microRNA expression in stress-induced cellular senescence by Li, Guorong, Luna, Coralia, Qiu, Jianming, Epstein, David L., Gonzalez, Pedro

“…We investigated miRNA expression changes associated with stress-induced premature senescence (SIPS) in primary cultures of human diploid fibroblast (HDF) and…”
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Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c by Luna, Coralia, Li, Guorong, Huang, Jianyong, Qiu, Jianming, Wu, Jing, Yuan, Fan, Epstein, David L, Gonzalez, Pedro

“…Lowering intraocular pressure (IOP) delays or prevents the loss of vision in primary open-angle glaucoma (POAG) patients with high IOP and in those with normal…”
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Cross-talk between miR-29 and transforming growth factor-betas in trabecular meshwork cells by Luna, Coralia, Li, Guorong, Qiu, Jianming, Epstein, David L, Gonzalez, Pedro

“…To investigate the interactions between microRNA-29 (miR-29), a negative regulator of extracellular matrix (ECM), and transforming growth factors (TGF)β-1 and…”
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Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress by Lin, Yizhi, Epstein, David L, Liton, Paloma B

“…To investigate the role of intralysosomal redox-active iron in oxidative stress-induced damage in trabecular meshwork (TM) cells. Chronic oxidative stress was…”
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Benefit from Bevacizumab for Macular Edema in Central Retinal Vein Occlusion: Twelve-Month Results of a Prospective, Randomized Study by Epstein, David L., MD, Algvere, Peep V., MD, PhD, von Wendt, Gunvor, MD, PhD, Seregard, Stefan, MD, PhD, Kvanta, Anders, MD, PhD

“…Purpose To evaluate the efficacy of intraocular injections with bevacizumab over 12 months in patients with macular edema (ME) secondary to central retinal…”
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Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells by Li, Guorong, Luna, Coralia, Qiu, Jianming, Epstein, David L, Gonzalez, Pedro

“…To investigate the alterations in microRNA (miRNA) expression during replicative senescence (RS) in human trabecular meshwork (HTM) cells. Two HTM cell lines…”
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Bevacizumab for Macular Edema in Central Retinal Vein Occlusion: A Prospective, Randomized, Double-Masked Clinical Study by Epstein, David L.J., MD, Algvere, Peep V., MD, PhD, von Wendt, Gunvor, MD, PhD, Seregard, Stefan, MD, PhD, Kvanta, Anders, MD, PhD

“…Purpose To evaluate the efficacy of intraocular injections with bevacizumab in patients with macular edema (ME) secondary to central retinal vein occlusion…”
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Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma by Rao, Vasantha P, Epstein, David L

“…Rho kinase (ROCK1 and ROCK2) is a serine/threonine kinase that serves as an important downstream effector of Rho GTPase, and plays a critical role in…”
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Rho GTPase-mediated cytoskeletal organization in Schlemm's canal cells play a critical role in the regulation of aqueous humor outflow facility by Kumar, Janardan, Epstein, David L.

“…The increased intraocular pressure (IOP) has been considered to be an increased resistance of the aqueous humor outflow through the inner wall of Schlemm's…”
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Inflow stenosis in arteriovenous fistulas and grafts: A multicenter, prospective study by Asif, Arif, Gadalean, Florin N., Merrill, Donna, Cherla, Gautam, Cipleu, Cristian D., Epstein, David L., Roth, David

“…Inflow stenosis in arteriovenous fistulas and grafts: A multicenter, prospective study. Traditionally, arteriovenous hemodialysis access inflow stenosis has…”
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Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells by Porter, Kristine M, Epstein, David L, Liton, Paloma B

“…Cells in the trabecular meshwork (TM), the tissue responsible for draining aqueous humor out of the eye, are known to be highly phagocytic. Phagocytic function…”
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Extracellular Release of ATP Mediated by Cyclic Mechanical Stress Leads to Mobilization of AA in Trabecular Meshwork Cells by Luna, Coralia, Li, Guorong, Qiu, Jianming, Challa, Pratap, Epstein, David L, Gonzalez, Pedro

“…To investigate the mechanisms that mediate the release of ATP induced by cyclic mechanical stress (CMS) and the role of extracellular ATP in the mobilization…”
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Cultured Porcine Trabecular Meshwork Cells Display Altered Lysosomal Function When Subjected to Chronic Oxidative Stress by Liton, Paloma B, Lin, Yizhi, Luna, Coralia, Li, Guorong, Gonzalez, Pedro, Epstein, David L

“…To investigate the effects of chronic oxidative stress on lysosomal function in trabecular meshwork (TM) cells. Confluent cultures of porcine TM cells were…”
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Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma by Liton, Paloma B., Lin, Yizhi, Gonzalez, Pedro, Epstein, David L.

“…Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the…”
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Influence of Actin Cytoskeletal Integrity on Matrix Metalloproteinase-2 Activation in Cultured Human Trabecular Meshwork Cells by Sanka, Krishna, Maddala, Rupalatha, Epstein, David L, Rao, P. Vasantha

“…The goal of this study was to investigate the possible link between actin cytoskeletal integrity and the activation of matrix metalloproteinases (MMPs) in…”
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Effects of Cholesterol-Lowering Statins on the Aqueous Humor Outflow Pathway by Song, Julia, Deng, Pei-Feng, Stinnett, Sandra S, Epstein, David L, Rao, P. Vasantha

“…To investigate the effects of cholesterol-lowering statin drugs on trabecular meshwork cellular properties and aqueous humor outflow. Primary cell cultures of…”
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Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells by Caballero, Montserrat, Liton, Paloma B, Epstein, David L, Gonzalez, Pedro

“…The pathophysiologic mechanisms leading to the malfunction of the trabecular meshwork (TM)–Schlemm’s canal (SC) outflow pathway in glaucoma are still unclear…”
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