Search Results - "Eppinga, Robbin D."

Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process by Cao, H, Eppinga, R D, Razidlo, G L, Krueger, E W, Chen, J, Qiang, L, McNiven, M A

“…Metastatic invasion of tumors into peripheral tissues is known to rely upon protease-mediated degradation of the surrounding stroma. This remodeling process…”
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Human tropomyosin isoforms in the regulation of cytoskeleton functions by Lin, Jim Jung-Ching, Eppinga, Robbin D, Warren, Kerri S, McCrae, Keith R

“…Over the past two decades, extensive molecular studies have identified multiple tropomyosin isoforms existing in all mammalian cells and tissues. In humans,…”
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Chapter 1 Roles of Caldesmon in Cell Motility and Actin Cytoskeleton Remodeling by Lin, Jim Jung‐Ching, Li, Yan, Eppinga, Robbin D., Wang, Qinchuan, Jin, Jian‐Ping

“…Caldesmon (CaD) is a multimodular protein that regulates contractility and actin cytoskeleton remodeling in smooth muscle and nonmuscle cells. A single gene…”
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Tropomyosin and caldesmon regulate cytokinesis speed and membrane stability during cell division by Eppinga, Robbin D., Li, Yan, Lin, Jenny L.-C., Lin, Jim J.-C.

“…The contractile ring and the cell cortex generate force to divide the cell while maintaining symmetrical shape. This requires temporal and spatial regulation…”
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Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration by Eppinga, Robbin D., Li, Yan, Lin, Jenny L.-C., Mak, Alan S., Lin, Jim J.-C.

“…Caldesmon is believed to be one of the key regulators for actin dynamics and thereby cell polarity, membrane extension, and cell motility. We have shown…”
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Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma by Eppinga, R D, Krueger, E W, Weller, S G, Zhang, L, Cao, H, McNiven, M A

“…Pancreatic ductal tumors invade local parenchyma and metastasize to distant organs. Src-mediated tyrosine kinase signaling pathways promote pancreatic ductal…”
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Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells by Eppinga, Robbin D., Peng, I-Feng, Lin, Jenny Li-Chun, Wu, Chun-Fang, Lin, Jim Jung-Ching

“…Myosin Va, an actin‐based motor protein that transports intracellular cargos, can bundle actin in vitro. Whether myosin Va regulates cellular actin dynamics or…”
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The roles of tropomyosin, caldesmon, and myosin Va in nonmuscle cell motility by Eppinga, Robbin D

“…Temporal and spatial regulation of the actin cytoskeleton controls nonmuscle cell movement. Although numerous actin-associated proteins have been studied…”
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Roles of Caldesmon in Cell Motility and Actin Cytoskeleton Remodeling

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