Dietary fat ratios and liver plasma membrane lipid composition

Male Sprague‐Dawley weanling rats were fed isocaloric diets consisting of 10% (by wt) fat. The six groups differed in the ratio of corn oil and butter fat present in the diets such that: 10C, 10% corn oil (C); 8C2B, 8% C/2% butter fat (B); 6C4B, 6% C/4% B; 4C6B, 4% C/6% B; 2C8B, 2% C/8% B; and 10B,...

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Bibliographic Details
Published in:	Lipids Vol. 23; no. 9; pp. 829 - 833
Main Authors:	Hamm, M.W, Sekowski, A, Ephrat, R
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer‐Verlag 01-09-1988 Springer
Subjects:	Animals Biological and medical sciences Cell Membrane - analysis CELL STRUCTURE CONTENIDO DE LIPIDOS CORPS GRAS Dietary Fats - administration & dosage Dietary Fats - pharmacology ESTRUCTURA CELULAR FATS Fatty Acids - analysis FOIE FOOD RATIONING Fundamental and applied biological sciences. Psychology GRASAS HIGADO LIPID CONTENT LIVER Liver - analysis Liver. Bile. Biliary tracts Male Membrane Lipids - analysis RACIONAMIENTO DE VIVERES RAT RATA RATIONNEMENT DES DENREES RATS Rats, Inbred Strains STRUCTURE CELLULAIRE TENEUR EN LIPIDES Vertebrates: digestive system Rat Liver Rodentia Butter Phospholipid Lipids Arachidonic acid Fatty acids Cholesterol Linoleic acid Vertebrata Mammalia Corn oil Food intake Plasma membrane Chemical composition Ratio
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Summary:	Male Sprague‐Dawley weanling rats were fed isocaloric diets consisting of 10% (by wt) fat. The six groups differed in the ratio of corn oil and butter fat present in the diets such that: 10C, 10% corn oil (C); 8C2B, 8% C/2% butter fat (B); 6C4B, 6% C/4% B; 4C6B, 4% C/6% B; 2C8B, 2% C/8% B; and 10B, 10% B. Liver plasma membranes were analyzed for fatty acid composition and cholesterol/phospholipid molar ratio. The 18∶2n−6 content was constant in the 10C and 8C2B diets and then decreased linearly through the 2C8B diet. The 20∶4n−6 and 18∶1n−9 contents were constant except in the 10B diet, in which a significant decrease and increase, respectively, were observed. The cholesterol/phospholipid molar ratio increased between the 10C and 6C4B diets and subsequently (4C6B and 10B diets) remained constant. This data indicates that changes in n−6 fatty acid content in the liver plasma membrane are directly related to dietary intake only for 18∶2n−6. Arachidonic acid content in the membrane is maintained at a constant level until the linoleic acid content of the diet is reduced to 0.5% of calories. It also indicates that the cholesterol content of the membrane becomes saturated and does not increase with increasing concentrations of saturated fat in the diet.
Bibliography:	S30 8861172 Presented in part at the FASEB Meeting, Washington, D.C., April, 1987. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0024-4201 1558-9307
DOI:	10.1007/BF02536200