Search Results - "Enyedi, Agnes"
-
1
Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation
Published in International journal of molecular sciences (09-05-2020)“…Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as…”
Get full text
Journal Article -
2
Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation
Published in Journal of experimental & clinical cancer research (26-06-2017)“…Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and…”
Get full text
Journal Article -
3
Apart from its basic function the plasma membrane Ca2+ATPase regulates Ca2+ signaling by controlling phosphatidylinositol-4,5-bisphosphate levels
Published in Journal of cell science (01-01-2013)“…Plasma membrane Ca2+ ATPases (PMCAs) are known targets of phosphatidylinositol-4,5-bisphosphate (PIP2), but if and how they control the PIP2 pool has not been…”
Get full text
Journal Article -
4
Glutamate‐induced protease‐mediated loss of plasma membrane Ca2+ pump activity in rat hippocampal neurons
Published in Journal of neurochemistry (01-09-2006)“…Ca2+ dysregulation is a hallmark of excitotoxicity, a process that underlies multiple neurodegenerative disorders. The plasma membrane Ca2+ ATPase (PMCA) plays…”
Get full text
Journal Article -
5
Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells
Published in BMC cancer (23-10-2018)“…Remodeling of Ca signaling is an important step in cancer progression, and altered expression of members of the Ca signaling toolkit including the plasma…”
Get full text
Journal Article -
6
Plasma membrane Ca2+ pump isoform 4 function in cell migration and cancer metastasis
Published in The Journal of physiology (01-04-2024)“…The Ca2+ ion is a universal second messenger involved in many vital physiological functions including cell migration and development. To fulfil these tasks the…”
Get full text
Journal Article -
7
SARS-CoV-2 envelope protein alters calcium signaling via SERCA interactions
Published in Scientific reports (11-09-2024)“…The clinical management of severe COVID-19 cases is not yet well resolved. Therefore, it is important to identify and characterize cell signaling pathways…”
Get full text
Journal Article -
8
Multifaceted plasma membrane Ca2+ pumps: From structure to intracellular Ca2+ handling and cancer
Published in Biochimica et biophysica acta. Molecular cell research (01-06-2016)“…Plasma membrane Ca2+ ATPases (PMCAs) are intimately involved in the control of intracellular Ca2+ concentration. They reduce Ca2+ in the cytosol not only by…”
Get full text
Journal Article -
9
The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition
Published in International journal of molecular sciences (19-03-2022)“…PMCA4 is a critical regulator of Ca homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been…”
Get full text
Journal Article -
10
Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells
Published in Biochemical and biophysical research communications (14-08-2015)“…We have previously presented co-expression of the plasma membrane calcium ATPase isoforms 4b (PMCA4b) and 1b (PMCA1b) in colon carcinoma cells, and selective…”
Get full text
Journal Article -
11
Decreased calcium pump expression in human erythrocytes is connected to a minor haplotype in the ATP2B4 gene
Published in Cell calcium (Edinburgh) (01-07-2017)“…Graphical abstract…”
Get full text
Journal Article -
12
Plasma Membrane Ca2+ Pump Isoforms 2a and 2b Are Unusually Responsive to Calmodulin and Ca2
Published in The Journal of biological chemistry (18-07-1997)“…The full-length a and b variants of the rat plasma membrane calcium pump, isoform 2 (rPMCA2a and rPMCA2b), were constructed and expressed in COS-7 cells. To…”
Get full text
Journal Article -
13
P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b
Published in Cells (Basel, Switzerland) (13-05-2020)“…Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca pump isoform 4b (PMCA4b or ) as a putative…”
Get full text
Journal Article -
14
B cell receptor-induced Ca2+ mobilization mediates F-actin rearrangements and is indispensable for adhesion and spreading of B lymphocytes
Published in Journal of leukocyte biology (01-04-2013)“…A molecular mechanism for Ca2+‐regulated actin cytoskeleton redistribution during B cell spreading on antigentethered surfaces. B cells acquire membrane‐bound…”
Get full text
Journal Article -
15
Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation
Published in The FEBS journal (01-11-2013)“…Cellular calcium signaling plays important roles in several signal transduction pathways that control proliferation, differentiation and apoptosis. In…”
Get full text
Journal Article -
16
Visualization of Calcium Dynamics in Kidney Proximal Tubules
Published in Journal of the American Society of Nephrology (01-11-2015)“…Intrarenal changes in cytoplasmic calcium levels have a key role in determining pathologic and pharmacologic responses in major kidney diseases. However,…”
Get full text
Journal Article -
17
Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca2+ Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK
Published in Frontiers in oncology (24-05-2017)“…Several new therapeutic options emerged recently to treat metastatic melanoma; however, the high frequency of intrinsic and acquired resistance among patients…”
Get full text
Journal Article -
18
A C-terminal di-leucine motif controls plasma membrane expression of PMCA4b
Published in Biochimica et biophysica acta (01-12-2013)“…Recent evidences show that the localization of different plasma membrane Ca2+ ATPases (PMCAs) is regulated in various complex, cell type-specific ways. Here we…”
Get full text
Journal Article -
19
Protein Kinase C Activates the Plasma Membrane Ca2+ Pump Isoform 4b by Phosphorylation of an Inhibitory Region Downstream of the Calmodulin-binding Domain
Published in The Journal of biological chemistry (13-12-1996)“…The carboxyl-terminal region of the plasma membrane Ca2+ pump isoform 4b contains two autoinhibitory regions which keep the pump inactive in the absence of…”
Get full text
Journal Article -
20
Apical Scaffolding Protein NHERF2 Modulates the Localization of Alternatively Spliced Plasma Membrane Ca2+ Pump 2B Variants in Polarized Epithelial Cells
Published in The Journal of biological chemistry (08-10-2010)“…The membrane localization of the plasma membrane Ca2+-ATPase isoform 2 (PMCA2) in polarized cells is determined by alternative splicing; the PMCA2w/b splice…”
Get full text
Journal Article