Search Results - "Enukashvily, Natella"
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Dysregulation of Transposon Transcription Profiles in Cancer Cells Resembles That of Embryonic Stem Cells
Published in Current issues in molecular biology (05-08-2024)“…Transposable elements (TEs) comprise a substantial portion of the mammalian genome, with potential implications for both embryonic development and cancer. This…”
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Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis
Published in Cell death & disease (12-01-2023)“…The abnormal tumor microenvironment (TME) often dictates the therapeutic response of cancer to chemo- and immuno-therapy. Aberrant expression of…”
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Pericentromeric Non-Coding DNA Transcription Is Associated with Niche Impairment in Patients with Ineffective or Partially Effective Multiple Myeloma Treatment
Published in International journal of molecular sciences (20-03-2022)“…Mesenchymal stromal cells (MSC) 'educated' by tumor cells are an essential component of the multiple myeloma (MM) tumor microenvironment (TME) involved in…”
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Overexpression of Pericentromeric HSAT2 DNA Increases Expression of EMT Markers in Human Epithelial Cancer Cell Lines
Published in International journal of molecular sciences (01-04-2023)“…Pericentromeric tandemly repeated DNA of human satellites 1, 2, and 3 (HS1, HS2, and HS3) is actively transcribed in some cells. However, the functionality of…”
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Comparative Analysis of Dental Pulp and Periodontal Stem Cells: Differences in Morphology, Functionality, Osteogenic Differentiation and Proteome
Published in Biomedicines (03-11-2021)“…Dental stem cells are heterogeneous in their properties. Despite their common origin from neural crest stem cells, they have different functional capacities…”
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Germ Granules in Animal Oogenesis
Published in Journal of developmental biology (09-10-2022)“…In eukaryotic cells, many macromolecules are organized as membraneless biomolecular condensates (or biocondensates). Liquid–liquid and liquid–solid phase…”
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Calcium signaling mediated by aminergic GPCRs is impaired by the PI3K inhibitor LY294002 and its analog LY303511 in a PI3K-independent manner
Published in European journal of pharmacology (05-08-2020)“…The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (LY294) and its much less active analog LY303511 (LY303) constitute the paired probe that is commonly…”
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Anti‐arthritic effect of chicken embryo tissue hydrolyzate against adjuvant arthritis in rats (X‐ray microtomographic and histopathological analysis)
Published in Food science & nutrition (01-10-2021)“…Finding new, safe strategies to prevent and control rheumatoid arthritis is an urgent task. Bioactive peptides and peptide‐rich protein hydrolyzate represent a…”
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Transcription of WNT Genes in Hematopoietic Niche's Mesenchymal Stem Cells in Multiple Myeloma Patients with Different Responses to Treatment
Published in Genes (17-05-2023)“…Mesenchymal stromal cells (MSCs) are involved in bone tissue remodeling due to their ability to differentiate into osteoblasts and to influence osteoclasts'…”
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Isolation of Human Osteoblast Cells Capable for Mineralization and Synthetizing Bone-Related Proteins In Vitro from Adult Bone
Published in Cells (Basel, Switzerland) (24-10-2022)“…The culture of osteoblasts (OB) of human origin is a useful experimental model in studying bone biology, osteogenic differentiation, functions of bone…”
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MPN-225 Next Generation Sequencing (NGS) in the Diagnosis, Prognosis and Features of the Disease in Ph-Negative Myeloproliferative Neoplasms
Published in Clinical lymphoma, myeloma and leukemia (01-10-2022)“…Over the past decade NGS has expanded our understanding of the genomic landscape of hematological malignancies. New biomarkers discovered during NGS are now…”
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Fibrin Glue Implants Seeded with Dental Pulp and Periodontal Ligament Stem Cells for the Repair of Periodontal Bone Defects: A Preclinical Study
Published in Bioengineering (Basel) (01-06-2021)“…A technology to create a cell-seeded fibrin-based implant matching the size and shape of bone defect is required to create an anatomical implant. The aim of…”
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Mammalian Satellite DNA: A Speaking Dumb
Published in Advances in Protein Chemistry and Structural Biology: Organisation of Chromosomes (2013)“…The tandemly organized highly repetitive satellite DNA is the main DNA component of centromeric/pericentromeric constitutive heterochromatin. For almost a…”
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RNA-seeded membraneless bodies: Role of tandemly repeated RNA
Published in Advances in protein chemistry and structural biology (01-01-2021)Get full text
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New types of mouse centromeric satellite DNAs
Published in Chromosome research (2005)“…Genomic databases do not contain complete sequences of the centromeric regions. We created a pUC19-based library of DNA fragments from isolated chromocentres…”
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Mesenchymal Cells Retain the Specificity of Embryonal Origin During Osteogenic Differentiation
Published in Stem cells (Dayton, Ohio) (13-01-2024)“…Mesenchymal stem cells (MSCs) are widely used in therapy, but the differences between MSCs of various origins and their ability to undergo osteogenic…”
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Transcription of IWNT/I Genes in Hematopoietic Niche’s Mesenchymal Stem Cells in Multiple Myeloma Patients with Different Responses to Treatment
Published in Genes (01-05-2023)“…Mesenchymal stromal cells (MSCs) are involved in bone tissue remodeling due to their ability to differentiate into osteoblasts and to influence osteoclasts'…”
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