Three new coordination geometries of homoleptic Zn complexes of curcuminoids and their high antiproliferative potential

To our previously reported first crystal structure of a homoleptic zinc curcuminoid complex with square pyramidal geometry, we add herein three new geometries of homoleptic type complexes i.e. octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Octahedral geometry was observed in the new pseud...

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Bibliographic Details
Published in:	RSC advances Vol. 13; no. 13; pp. 8577 - 8585
Main Authors:	Meza-Morales, William, Alvarez-Ricardo, Yair, Obregón-Mendoza, Marco A, Arenaza-Corona, Antonino, Ramírez-Apan, María Teresa, Toscano, Rubén A, Poveda-Jaramillo, Juan Carlos, Enrquez, Raúl G
Format:	Journal Article
Language:	English
Published:	England Royal Society of Chemistry 14-03-2023 The Royal Society of Chemistry
Subjects:	Antiproliferatives Chemistry Crystal structure Crystallization Esterification NMR Nuclear magnetic resonance Zinc
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Summary:	To our previously reported first crystal structure of a homoleptic zinc curcuminoid complex with square pyramidal geometry, we add herein three new geometries of homoleptic type complexes i.e. octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Octahedral geometry was observed in the new pseudo-polymorph of the DAC-Zn complex resulting from crystallization in DMF, while square-pyramidal geometry was obtained in DMSO. Improving crystallinity involved suppressing the phenolic interactions by etherification and esterification. The complete characterization of these complexes was carried out using SCXRD, IR, MS, EA, liquid, and solid-state NMR. Moreover, the cytotoxic activity of all complexes was evaluated. The IC 50 values for the DiMeOC-Zn ( 7 ) complex were 8 or 22 times higher than for cisplatin in the U251 and HCT-15 cell lines, indicating a high antiproliferative and therapeutic potential. We add herein three new geometries of homoleptic type complexes i.e. octahedral, trigonal-pyramidal, and trigonal-bipyramidal. Moreover, the IC 50 values for the DiMeOC-Zn complex were 8 or 22 times higher than cisplatin in the U251 and HCT15 cell lines.
Bibliography:	Electronic supplementary information (ESI) available. CCDC https://doi.org/10.1039/d3ra00167a For ESI and crystallographic data in CIF or other electronic format see DOI 2234961-2234963 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2046-2069 2046-2069
DOI:	10.1039/d3ra00167a