Development of Simple and Sensitive Score to Assess the Risk of Pneumonia in COVID-19 Patients

Development of Simple and Sensitive Score to Assess the Risk of Pneumonia in COVID-19 Patients

Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the pre-hospital setting were created. The objective of the stud...

Full description

Saved in:
Bibliographic Details
Published in:Revista de investigacion clinica Vol. 73; no. 1; pp. 052 - 058
Main Authors: Hormanstorfer, Macarena, Ragusa, Martin A, Poggio, Lucia, Moreira-Facundo, Jorge, Orellana-Villa, Zulma, Bobrowski, Florencia A, Martinez-Serventi, Joaquin, Piombi Adanza, Santiago N, Enrique Barletta, Jose A, Sisto, Alicia, Delle-Piane, Hugo, Carrillo, Juan M, Presas, Jose L, Paulin, Francisco
Format: Journal Article
Language:English
Published: Mexico 19-10-2020
Subjects:
Adolescent
Adult
Argentina
Cohort Studies
COVID-19 - complications
COVID-19 - diagnosis
Cross-Sectional Studies
Female
Fever - diagnosis
Fever - virology
Humans
Intensive Care Units
Male
Middle Aged
Pneumonia, Viral - diagnosis
Pneumonia, Viral - etiology
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Risk
Sensitivity and Specificity
Severity of Illness Index
Young Adult
Argentina
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Severe pneumonia is the most common cause of intensive care unit (ICU) admission and death due to novel coronavirus (SARS-CoV-2) respiratory disease (COVID-19). Due to its rapid outbreak, units for the evaluation of febrile patients in the pre-hospital setting were created. The objective of the study was to develop a sensitive and simple tool to assess the risk of pneumonia in COVID-19 patients and thus select which patients would require a chest imaging study. We conducted a cross-sectional study in a cohort of individuals with suspected COVID-19 evaluated in a public academic healthcare center in Buenos Aires city. All adult patients with positive RT-PCR assay for SARS-COV2 between April 24 and May 19 of 2020 were included in the study. Pneumonia was defined as the presence of compatible signs and symptoms with imaging confirmation. Univariate and multivariate logistic regression was performed. A risk indicator score was developed. One hundred and forty-eight patients were included, 71 (48%) received the diagnosis of pneumonia. The final clinical model included four variables: age >- 40 years, cough, absence of sore throat, and respiratory rate >- 22. To create the score, we assigned values to the variables according to their ORs: 2 points for respiratory rate >- 22 and 1 point to the other variables. The AUC of the ROC curve was 0.80 (CI 95% 0.73-0.86). A cutoff value of 2 showed a sensitivity of 95.7% and a specificity of 43.24%. This sensible score may improve the risk stratification of COVID-19 patients in the pre-hospital setting.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0034-8376
DOI:10.24875/RIC.20000295