Search Results - "Enose, Yoshimi"
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Imaging spinal cord atrophy in progressive myelopathies: HTLV‐I‐associated neurological disease (HAM/TSP) and multiple sclerosis (MS)
Published in Annals of neurology (01-11-2017)“…Objective Previous work measures spinal cord thinning in chronic progressive myelopathies, including human T‐lymphotropic virus 1 (HTLV‐1)‐associated…”
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Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Published in Retrovirology (29-11-2019)“…Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately 10-20 million people worldwide. While the majority of infected…”
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Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy
Published in The New England journal of medicine (25-04-2019)“…Eight patients with progressive multifocal leukoencephalopathy associated with chronic lymphocytic leukemia, HIV infection, lymphoma, or idiopathic lymphopenia…”
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Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
Published in Frontiers in microbiology (21-12-2017)“…Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated…”
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T cell receptor repertoire analysis in HTLV-1-associated diseases
Published in Frontiers in immunology (15-09-2022)“…Human T lymphotropic virus 1 (HTLV-1) is a human retrovirus identified as the causative agent in adult T-cell leukemia/lymphoma (ATL) and chronic-progressive…”
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Clinical trial of raltegravir, an integrase inhibitor, in HAM/TSP
Published in Annals of clinical and translational neurology (01-10-2021)“…Objective Human T‐cell lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive myelopathy. A high…”
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BK virus-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy: an open-label, single-cohort pilot study
Published in Lancet neurology (01-08-2021)“…Progressive multifocal leukoencephalopathy, a rare disease of the CNS caused by JC virus and occurring in immunosuppressed people, is typically fatal unless…”
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Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals
Published in Retrovirology (13-02-2013)“…Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated…”
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Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases
Published in PLoS pathogens (30-04-2018)“…Intrathecal antibody synthesis is a well-documented phenomenon in infectious neurological diseases as well as in demyelinating diseases, but little is known…”
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Clinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP
Published in Annals of clinical and translational neurology (01-08-2019)“…Objective Human T cell lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive, neurological…”
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Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis
Published in Proceedings of the National Academy of Sciences - PNAS (01-09-2015)“…Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive inflammatory myelopathy occurring…”
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Viral Immune signatures from cerebrospinal fluid extracellular vesicles and particles in HAM and other chronic neurological diseases
Published in Frontiers in immunology (09-08-2023)“…Extracellular vesicles and particles (EVPs) are released from virtually all cell types, and may package many inflammatory factors and, in the case of…”
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Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes
Published in Clinical and translational medicine (27-08-2018)“…Background HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called…”
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Quantitative differences in HTLV-I antibody responses: classification and relative risk assessment for asymptomatic carriers and ATL and HAM/TSP patients from Jamaica
Published in Blood (22-03-2012)“…Adult T-cell leukemia (ATL) and human T-cell lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) are known to be…”
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Identification and tracking of HTLV-1-infected T cell clones in virus-associated neurologic disease
Published in JCI insight (10-04-2023)“…Human T lymphotropic virus type 1-assoicated (HTLV-1-associated) myelopathy/tropical spastic paraparesis (HAM/TSP) is a neuroinflammatory disease caused by the…”
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Co-dependence of HTLV-1 p12 and p8 functions in virus persistence
Published in PLoS pathogens (01-11-2014)“…HTLV-1 orf-I is linked to immune evasion, viral replication and persistence. Examining the orf-I sequence of 160 HTLV-1-infected individuals; we found…”
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High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease
Published in PLoS pathogens (01-12-2009)“…HTLV-I-specific CD8(+) T cells have been characterized with high frequencies in peripheral blood and cerebrospinal fluid and production of proinflammatory…”
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Epigenetic Modification of the FoxP3 TSDR in HAM/TSP Decreases the Functional Suppression of Tregs
Published in Journal of neuroimmune pharmacology (01-09-2014)“…HTLV-1 is a human retrovirus that is associated with the neuroinflammatory disorder HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In…”
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Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease
Published in JCI insight (22-02-2021)“…In this study, we examined and characterized disease-specific TCR signatures in cerebrospinal fluid (CSF) of patients with HTLV-1-associated…”
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Rapid dissemination of a pathogenic simian/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection
Published in Journal of general virology (01-05-2006)“…1 Institute for Virus Research, Laboratory of Primate Model, Experimental Research Center for Infectious Disease, Kyoto University, Sakyo-ku, Kyoto 606-8507,…”
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