The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model

The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model

Patient derived xenograft (PDX) is a powerful tool to confirm pharmacological efficacy in non-clinical studies for the development of various drugs including anti-cancer agents and therapeutic research. A standardized extract of cultured Lentinula edodes mycelia, a product name AHCC® is produced by...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin Vol. 47; no. 2; pp. 532 - 538
Main Authors: Yoshii, Remi, Adachi, Shigeki, Ryo, Haruko, Hatanaka, Eiko, Yasuda, Koujun, Kaji, Momoyo, Enomoto, Kumiko, Takanari, Jun, Yoshidome, Katsuhide, Nomura, Taisei, Tomiyama, Noriyuki
Format: Journal Article
Language:English
Published: Japan The Pharmaceutical Society of Japan 28-02-2024
Japan Science and Technology Agency
Subjects:
Animals
Antineoplastic drugs
BCG Vaccine
Breast cancer
Breast Neoplasms - drug therapy
Drug development
Female
functional food
Functional foods & nutraceuticals
Heterografts
Humans
Immunosuppressive agents
Invasiveness
Kidney cancer
Kidney Neoplasms - drug therapy
Kidney transplantation
Lentinula edodes
Mice
Mice, SCID
Oral administration
patient derived xenograft (PDX)
renal cancer
Severe combined immunodeficiency
severe combined immunodeficient (SCID)
Shiitake Mushrooms
standardized extract of cultured Lentinula edodes mycelia (ECLM)
Tumors
Xenograft Model Antitumor Assays
Xenografts
standardized extract of cultured Lentinula edodes mycelia (ECLM)
breast cancer
renal cancer
patient derived xenograft (PDX)
functional food
severe combined immunodeficient (SCID)
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Summary:Patient derived xenograft (PDX) is a powerful tool to confirm pharmacological efficacy in non-clinical studies for the development of various drugs including anti-cancer agents and therapeutic research. A standardized extract of cultured Lentinula edodes mycelia, a product name AHCC® is produced by Amino Up Co., Ltd. (Sapporo, Japan). In this study, we investigated the inhibitory effect of AHCC® on the growth of tumor PDX in Super SCID (severe combined immunodeficiency) mice. Effects of AHCC® and BCG administration on the growth of renal cancer PDX implanted in Super SCID mice were evaluated by PDX growth curve. Tendency for the effects on the growth of renal cancer PDX in Super SCID by administration of AHCC® and BCG before implanting the PDX were demonstrated. The effects of the oral administration of AHCC® on the growth of renal, invasive and non-invasive breast cancer PDX in Super SCID mice were studied. In Super SCID mice transplanted with renal cancer PDX, AHCC® significantly suppressed tumor proliferation from the day 48 to 83 after transplantation. In two types of breast cancer PDX, tendency of the growth inhibitory effects of AHCC® were shown by PDX growth curve. Significant inhibitory effect was found at only one time point for during proliferation in each PDX. Super SCID-PDX model has the potential to be a useful tool to investigate for the effect of functional foods.
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b23-00734