Search Results - "Enns, C A"

A mutated transferrin receptor lacking asparagine-linked glycosylation sites shows reduced functionality and an association with binding immunoglobulin protein by WILLIAMS, A. M, ENNS, C. A

“…The function of the transferrin receptor is to transport iron-bound transferrin into the cell. In order to function properly, this dimeric glycoprotein must be…”
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A region of the C-terminal portion of the human transferrin receptor contains an asparagine-linked glycosylation site critical for receptor structure and function by WILLIAMS, A. M, ENNS, C. A

“…The transferrin receptor is a cell surface protein and is responsible for the uptake of iron into many eukaryotic cells. In its mature form, the receptor…”
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Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE by West, Jr, A P, Bennett, M J, Sellers, V M, Andrews, N C, Enns, C A, Bjorkman, P J

“…The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary…”
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Type IV pili of pathogenic Neisseriae elicit cortical plaque formation in epithelial cells by Merz, Alexey J., Enns, Caroline A., So, Magdalene

“…The pathogenic Neisseriae Neisseria meningitidis and Neisseria gonorrhoeae, initiate colonization by attaching to host cells using type IV pili. Subsequent…”
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Characterization of the transferrin receptor in tunicamycin-treated A431 cells by Reckhow, C L, Enns, C A

“…The transferrin receptor undergoes extensive co- and post-translational modifications during its biosynthesis. In this study, the functional and structural…”
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The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells by Roy, C N, Penny, D M, Feder, J N, Enns, C A

“…HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N., Gnirke, A., Thomas, W.,…”
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Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation by Gross, Cindy N., Irrinki, Alivelu, Feder, John N., Enns, Caroline A.

“…The mechanism by which a novel major histocompatibility complex class I protein, HFE, regulates iron uptake into the body is not known. HFE is the product of…”
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Generation of the soluble transferrin receptor requires cycling through an endosomal compartment by Rutledge, E.A., Green, F.A., Enns, C.A.

“…The transmembrane protein, transferrin receptor (TfR), is found in a soluble form in human serum and in the medium of cell lines grown in tissue culture. The…”
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Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor by Enns, Caroline A.

“…People suffering from hereditary hemochromatosis (HH) can not regulate the uptake of iron properly and gradually accumulate iron in their body over their…”
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Physical characterization of the transferrin receptor in human placentae by Enns, C A, Sussman, H H

“…The physical properties and binding characteristics of the solubilized transferrin receptor isolated from the placental brush-border membrane of a human…”
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Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor by RUTHLEDGE, E. A, ROOT, B. J, LUCAS, J. J, ENNS, C. A

“…The transferrin receptor (TfR) is the plasma membrane protein responsible for the binding and internalization of the major iron-transport protein, transferrin…”
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Co-Migration and Internalization of Transferrin and Its Receptor on K562 Cells by Enns, Caroline A., Larrick, James W., Suomalainen, Heli, Schroder, Jim, Sussman, Howard H.

“…The incorporation of iron into human cells involves the binding of diferric transferrin to a specific cell surface receptor. We studied the process of…”
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Acquisition of the functional properties of the transferrin receptor during its biosynthesis by ENNS, C. QA, CLINTON, E. M, RECKHOW, C. L, ROOT, B. J, SO-ILL DO, COOK, C

“…The properties of the newly synthesized and partially glycosylated forms of the transferrin receptor were examined to determine which co- and…”
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Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway by Liu, G.P, Thomas, L, Warren, R.A, Enns, C.A, Cunningham, C.C, Hartwig, J.H, Thomas, G

“…Furin catalyzes the proteolytic maturation of many proproteins within the trans-Golgi network (TGN)/endosomal system. Furin's cytosolic domain (cd) directs…”
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Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs by Warren, R A, Green, F A, Stenberg, P E, Enns, C A

“…Endocytosis of surface proteins through clathrin-coated pits requires an internalization signal in the cytoplasmic domain. Two types of internalization signal…”
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Radioimmunochemical Measurement of the Transferrin Receptor in Human Trophoblast and Reticulocyte Membranes with a Specific Anti-Receptor Antibody by Enns, Caroline A., Shindelman, Jeffrey E., Tonik, Susan E., Sussman, Howard H.

“…A radioimmunoassay was developed to directly assay the presence of transferrin receptors in human tissues. Antisera developed in a goat against purified human…”
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Characterization of proteins that associate with an unglycosylated form of the transferrin receptor in A431 cells by Root, B J, Reckhow, C L, Clinton, E M, Enns, C A

“…A protein doublet (Mr = 135,000/130,000) was found to coprecipitate with an unglycosylated form of the transferrin receptor in tunicamycin-treated A431 cells…”
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Human Transferrin Receptor: Expression of the Receptor is Assigned to Chromosome 3 by Enns, Caroline A., Suomalainen, Heli A., Gebhardt, Janice E., Schroder, Jim, Sussman, Howard H.

“…Human chromosome 3 has been identified as responsible for expression of the transferrin receptor in mouse-human lymphocyte hybrids. The receptor was detected…”
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Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor by Warren, Robin A., Green, Frank A., Enns, Caroline A.

“…Cell-surface receptors that undergo clathrin-mediated endocytosis contain short amino acid sequences in their cytoplasmic domain that serve as internalization…”
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Similarities between the transferrin receptor proteins on human reticulocytes and human placentae by Enns, C A, Sussman, H H

“…The transferrin receptor of the human reticulocyte was isolated by two different immunoaffinity procedures. These included indirect immunoprecipitation with a…”
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