Search Results - "Englund, P T"

RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA by Wang, Zefeng, Englund, Paul T.

“…We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference (RNAi). Expression of a topoisomerase II double‐stranded RNA as a…”
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The Structure and Biosynthesis of Glycosyl Phosphatidylinositol Protein Anchors by Englund, P T

“…In this review I focus on the structure and biosynthesis of GPIs. The reader should also refer to other recent reviews and to special issues of journals that…”
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The Structure and Replication of Kinetoplast DNA by Shapiro, T A, Englund, P T

“…The mitochondrial DNA of trypanosomatid protozoa, termed kinetoplast DNA (kDNA), is unique in its structure, function, and mode of replication. kDNA is a…”
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Specialized Fatty Acid Synthesis in African Trypanosomes: Myristate for GPI Anchors by Morita, Yasu S., Paul, Kimberly S., Englund, Paul T.

“…African trypanosomes, the cause of sleeping sickness, need massive amounts of myristate to remodel glycosyl phosphatidylinositol (GPI) anchors on their surface…”
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Selective Cleavage of Kinetoplast DNA Minicircles Promoted by Antitrypanosomal Drugs by Shapiro, Theresa A., Englund, Paul T.

“…Pentamidine, diminazene aceturate (Berenil), isometamidium chloride (Samorin), and ethidium bromide, which are important antitrypanosomal drugs, promote…”
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Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine by DOERING, T. L, MASTERSON, W. J, ENGLUND, P. T, HART, G. W

“…Non-acetylated glucosamine is an unusual structural feature shared by all glycosyl phosphatidylinositol (GPI) lipids, including a variety of membrane anchors,…”
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Fellowship of the rings: the replication of kinetoplast DNA by Liu, Beiyu, Liu, Yanan, Motyka, Shawn A., Agbo, Eddy E.C., Englund, Paul T.

“…Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most…”
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Four Trypanosoma brucei fatty acyl-CoA synthetases: fatty acid specificity of the recombinant proteins by Jiang, D W, Englund, P T

“…As part of our investigation of fatty acid metabolism in Trypanosoma brucei, we have expressed four acyl-CoA synthetase (TbACS) genes in Esherichia coli. The…”
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Inhibition of Trypanosoma brucei Gene Expression by RNA Interference Using an Integratable Vector with Opposing T7 Promoters by Wang, Zefeng, Morris, James C., Drew, Mark E., Englund, Paul T.

“…RNA interference is a powerful method for inhibition of gene expression in Trypanosoma brucei(Ngo, H., Tschudi, C., Gull, K., and Ullu, E. (1998) Proc. Natl…”
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A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the trypanosome variant surface glycoprotein by Masterson, W J, Doering, T L, Hart, G W, Englund, P T

“…The trypanosome variant surface glycoprotein (VSG), like many other eukaryotic cell surface proteins, is anchored to the plasma membrane by a…”
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A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein by Hereld, D, Krakow, J L, Bangs, J D, Hart, G W, Englund, P T

“…The surface coat of Trypanosoma brucei is composed of 10(7) molecules of the variant surface glycoprotein (VSG). Each VSG molecule is tethered to the cell…”
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Biosynthesis of a variant surface glycoprotein of Trypanosoma brucei. Processing of the glycolipid membrane anchor and N-linked oligosaccharides by Bangs, J D, Doering, T L, Englund, P T, Hart, G W

“…The variant surface glycoprotein (VSG) of the ILTat 1.3 variant of Trypanosoma brucei has two asparagine-linked glycan moieties, as well as a…”
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Identification of a glycolipid precursor of the Trypanosoma brucei variant surface glycoprotein by Krakow, J L, Hereld, D, Bangs, J D, Hart, G W, Englund, P T

“…The variant surface glycoprotein (VSG) of Trypanosoma brucei has a glycolipid covalently attached to its C terminus. This glycolipid, which anchors the protein…”
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Changes in network topology during the replication of kinetoplast DNA by Chen, J., Englund, P. T., Cozzarelli, N. R.

“…Kinetoplast DNA of Crithidia fasciculata is a network containing several thousand topologically interlocked DNA minicircles. In the prereplicative Form I…”
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The attachment of minicircles to kinetoplast DNA networks during replication by Pérez-Morga, D L, Englund, P T

“…Kinetoplast DNA (kDNA), the trypanosomatid mitochondrial DNA, is a network containing several thousand interlocked minicircles. During kDNA synthesis,…”
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Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein by Bangs, J.D, Hereld, D, Krakow, J.L, Hart, G.W, Eglund, P.T

“…The variant surface glycoprotein of the parasite Trypanosoma brucei contains a glycolipid of unknown structure covalently attached to its COOH terminus. We…”
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Biosynthesis of glycosyl phosphatidylinositol membrane anchors by DOERING, T. L, MASTERSON, W. J, HART, G. W, ENGLUND, P. T

“…Faced with the problem of membrane attachment, proteins resort to several solutions. For example, many bond to biological membranes via some type of lipid…”
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Kinetoplast maxicircle DNA replication in Crithidia fasciculata and Trypanosoma brucei by Carpenter, Laura Rocco, Englund, Paul T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria by SHAPIRO, T. A, KLEIN, V. A, ENGLUND, P. T

“…Minicircle DNA, the major component of the mitochondrial DNA of trypanosomes (kinetoplast DNA), is linearized when living Trypanosoma equiperdum cells are…”
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A Glycan-Phosphatidylinositol-Specific Phospholipase D in Human Serum by Davitz, Michael A., Hereld, Dale, Shak, Steve, Krakow, Jessica, Englund, Paul T., Nussenzweig, Victor

“…A group of proteins anchored to the cell by phosphatidylinositol (PI) has recently been identified. The significance of this new class of membrane anchor is…”
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