Search Results - "Englund, P"

The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries: Osteoarthritis by Lohmander, L. Stefan, Englund, P. Martin, Dahl, Ludvig L., Roos, Ewa M.

“…The objectives of this study are to review the long-term consequences of injuries to the anterior cruciate ligament and menisci, the pathogenic mechanisms, and…”
Get full text

Essential role of stromally induced hedgehog signaling in B-cell malignancies by Dierks, Christine, Warmuth, Markus, Grbic, Jovana, Zirlik, Katja, Beigi, Ronak, Englund, Nathan P, Guo, Gui-Rong, Veelken, Hendrik, Engelhardt, Monika, Mertelsmann, Roland, Kelleher, Joseph F, Schultz, Peter

“…Interaction of cancer cells with their microenvironment generated by stromal cells is essential for tumor cell survival and influences the localization of…”
Get full text

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist by Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion

“…The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was…”
Get full text

RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA by Wang, Zefeng, Englund, Paul T.

“…We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference (RNAi). Expression of a topoisomerase II double‐stranded RNA as a…”
Get full text

The Structure and Biosynthesis of Glycosyl Phosphatidylinositol Protein Anchors by Englund, P T

“…In this review I focus on the structure and biosynthesis of GPIs. The reader should also refer to other recent reviews and to special issues of journals that…”
Get full text

Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis by Dorph, C, Englund, P, Nennesmo, I, Lundberg, I E

“…Objectives: To determine whether muscle weakness is correlated with inflammation, expression of interleukin 1α (IL1α) and major histocompatibility complex…”
Get full text

Paediatric ventilation treatment of acute lung injury in Nordic intensive care units by JENSEN, L. L., BARATT-DUE, A., ENGLUND, P. N., HARJU, J. A., SIGURÐSSON, T. S., LIBERG, J.-P.

“…Background Treatment of acute respiratory distress syndrome (ARDS) in children is largely based on extrapolated knowledge obtained from adults and which varies…”
Get full text

The Structure and Replication of Kinetoplast DNA by Shapiro, T A, Englund, P T

“…The mitochondrial DNA of trypanosomatid protozoa, termed kinetoplast DNA (kDNA), is unique in its structure, function, and mode of replication. kDNA is a…”
Get full text

Fellowship of the rings: the replication of kinetoplast DNA by Liu, Beiyu, Liu, Yanan, Motyka, Shawn A., Agbo, Eddy E.C., Englund, Paul T.

“…Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most…”
Get full text

Specialized Fatty Acid Synthesis in African Trypanosomes: Myristate for GPI Anchors by Morita, Yasu S., Paul, Kimberly S., Englund, Paul T.

“…African trypanosomes, the cause of sleeping sickness, need massive amounts of myristate to remodel glycosyl phosphatidylinositol (GPI) anchors on their surface…”
Get full text

Inhibition of Trypanosoma brucei Gene Expression by RNA Interference Using an Integratable Vector with Opposing T7 Promoters by Wang, Zefeng, Morris, James C., Drew, Mark E., Englund, Paul T.

“…RNA interference is a powerful method for inhibition of gene expression in Trypanosoma brucei(Ngo, H., Tschudi, C., Gull, K., and Ullu, E. (1998) Proc. Natl…”
Get full text

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia by Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

“…Frank Stegmeier, Levi Garraway and colleagues apply a targeted mass spectrometry approach that measures level of histone modifications and identify a recurrent…”
Get full text

Multiple Mitochondrial DNA Polymerases in Trypanosoma brucei by Klingbeil, Michele M., Motyka, Shawn A., Englund, Paul T.

“…Kinetoplast DNA (kDNA), the unusual mitochondrial DNA of Trypanosoma brucei, is a network containing thousands of catenated circles. Database searching for a…”
Get full text

Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library by Morris, James C., Wang, Zefeng, Drew, Mark E., Englund, Paul T.

“…RNA interference (RNAi) is a powerful tool for identifying gene function in Trypanosoma brucei. We generated an RNAi library, the first of its kind in any…”
Get full text

Quality of Care and Use of the Medical Home in a State-Funded Capitated Primary Care Plan For Low-Income Children by Kempe, Allison, Beaty, Brenda, Englund, Brian P, Roark, Robert J, Hester, Nellie, Steiner, John F

“…To evaluate the quality of care and use of the medical home in a state-funded capitated insurance plan for low-income children-the Colorado Child Health Plan…”
Get full text

Selective Cleavage of Kinetoplast DNA Minicircles Promoted by Antitrypanosomal Drugs by Shapiro, Theresa A., Englund, Paul T.

“…Pentamidine, diminazene aceturate (Berenil), isometamidium chloride (Samorin), and ethidium bromide, which are important antitrypanosomal drugs, promote…”
Get full text

Trypanosoma brucei Has Two Distinct Mitochondrial DNA Polymerase β Enzymes by Saxowsky, Tina T., Choudhary, Gunjan, Klingbeil, Michele M., Englund, Paul T.

“…In higher eukaryotes, DNA polymerase (pol) β resides in the nucleus and participates primarily in DNA repair. The DNA polymerase β from the trypanosomatid…”
Get full text

The Surface Coat of Procyclic Trypanosoma Brucei: Programmed Expression and Proteolytic Cleavage of Procyclin in the Tsetse Fly by Acosta-Serrano, Alvaro, Vassella, Erik, Liniger, Matthias, Renggli, Christina Kunz, Brun, Reto, Roditi, Isabel, Englund, Paul T.

“…Trypanosoma brucei, the protozoan parasite causing sleeping sickness, is transmitted by a tsetse fly vector. When the tsetse takes a blood meal from an…”
Get full text

Increased endothelial expression of HLA‐DQ and interleukin 1α in extra‐articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle by Turesson, C., Englund, P., Jacobsson, L. T. H., Sturfelt, G., Truedsson, L., Nennesmo, I., Lundberg, I. E.

“…Objective. To investigate markers of endothelial activation in muscle biopsies from rheumatoid arthritis (RA) patients with and without extra‐articular…”
Get full text

Four Trypanosoma brucei fatty acyl-CoA synthetases: fatty acid specificity of the recombinant proteins by Jiang, D W, Englund, P T

“…As part of our investigation of fatty acid metabolism in Trypanosoma brucei, we have expressed four acyl-CoA synthetase (TbACS) genes in Esherichia coli. The…”
Get full text