Search Results - "Englund, Johanna I"
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1
Metabolic determination of cell fate through selective inheritance of mitochondria
Published in Nature cell biology (01-02-2022)“…Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and cellular metabolism is emerging as a potential driver of cell…”
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2
Laminin matrix adhesion regulates basal mammary epithelial cell identity
Published in Journal of cell science (01-12-2022)“…Mammary epithelium is a bilayered ductal network composed of luminal and basal epithelial cells, which together drive the growth and functional differentiation…”
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3
Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk
Published in Development (Cambridge) (15-06-2021)“…Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet the exact roles of specific BM components remain unclear…”
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Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin
Published in Cancer research (Chicago, Ill.) (15-03-2021)“…Ras proteins play a causal role in human cancer by activating multiple pathways that promote cancer growth and invasion. However, little is known about how Ras…”
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“Tonga”: A Novel Toolbox for Straightforward Bioimage Analysis
Published in Frontiers in computer science (Lausanne) (31-03-2022)“…Techniques to acquire and analyze biological images are central to life science. However, the workflow downstream of imaging can be complex and involve several…”
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Cellular shape reinforces niche to stem cell signaling in the small intestine
Published in Science advances (14-10-2022)“…Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory pathways, the effect of niche geometry is not well understood. We used…”
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Published in Nature (London) (17-06-2021)“…The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice…”
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Apc-mutant cells deploy Notum to bias clonal competition and drive cancer
Published in Nature (London) (01-06-2021)“…The APC tumour suppressor is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells (ISCs) drives adenoma formation in mice…”
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