Search Results - "English, Justin G."

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome by Olsen, Reid H. J., DiBerto, Jeffrey F., English, Justin G., Glaudin, Alexis M., Krumm, Brian E., Slocum, Samuel T., Che, Tao, Gavin, Ariana C., McCorvy, John D., Roth, Bryan L., Strachan, Ryan T.

“…G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal…”
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Structure, function and pharmacology of human itch GPCRs by Cao, Can, Kang, Hye Jin, Singh, Isha, Chen, He, Zhang, Chengwei, Ye, Wenlei, Hayes, Byron W., Liu, Jing, Gumpper, Ryan H., Bender, Brian J., Slocum, Samuel T., Krumm, Brian E., Lansu, Katherine, McCorvy, John D., Kroeze, Wesley K., English, Justin G., DiBerto, Jeffrey F., Olsen, Reid H. J., Huang, Xi-Ping, Zhang, Shicheng, Liu, Yongfeng, Kim, Kuglae, Karpiak, Joel, Jan, Lily Y., Abraham, Soman N., Jin, Jian, Shoichet, Brian K., Fay, Jonathan F., Roth, Bryan L.

“…The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently 1 . Of these, MRGPRX2…”
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VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells by English, Justin G., Olsen, Reid H.J., Lansu, Katherine, Patel, Michael, White, Karoline, Cockrell, Adam S., Singh, Darshan, Strachan, Ryan T., Wacker, Daniel, Roth, Bryan L.

“…Directed evolution, artificial selection toward designed objectives, is routinely used to develop new molecular tools and therapeutics. Successful directed…”
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Ion-ing out the genetic variants of Kir2.1 by Fallon, Braden S, English, Justin G

“…Deep mutational scanning provides new insights into how mutations alter the expression and activity of the potassium ion channel Kir2.1, which is associated…”
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A biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ by Tao, Andrew J., Jiang, Jiewei, Gadbois, Gillian E., Goyal, Pavitra, Boyle, Bridget T., Mumby, Elizabeth J., Myers, Samuel A., English, Justin G., Ferguson, Fleur M.

“…Understanding how small molecules bind to specific protein complexes in living cells is critical to understanding their mechanism-of-action. Unbiased chemical…”
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MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast by English, Justin G, Shellhammer, James P, Malahe, Michael, McCarter, Patrick C, Elston, Timothy C, Dohlman, Henrik G

“…Signaling pathways can behave as switches or rheostats, generating binary or graded responses to a given cell stimulus. We evaluated whether a single signaling…”
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Advancements in G protein‐coupled receptor biosensors to study GPCR‐G protein coupling by Olsen, Reid H. J., English, Justin G.

“…Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein‐coupled…”
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Measuring Ligand‐bound Protein Complexes with Proximity Labeling: A Practical Guide by Goyal, Pavitra, Tao, Andrew J., Mumby, Elizabeth J., English, Justin G., Ferguson, Fleur M.

“…Identifying the drug‐target interactome of small molecule therapeutics is essential for understanding the full pharmacological effects of a compound. These…”
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Chemogenetics-A Transformational and Translational Platform by English, Justin G, Roth, Bryan L

“…Neurologic disorders are frequently a result of inappropriate electrical and/or chemical signaling of neurons and glia. Ultimate remediation would necessitate…”
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VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells by English, Justin G., Olsen, Reid H.J., Lansu, Katherine, Patel, Michael, White, Karoline, Cockrell, Adam S., Singh, Darshan, Strachan, Ryan T., Wacker, Daniel, Roth, Bryan L.

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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys by Nagai, Yuji, Miyakawa, Naohisa, Takuwa, Hiroyuki, Hori, Yukiko, Oyama, Kei, Ji, Bin, Takahashi, Manami, Huang, Xi-Ping, Slocum, Samuel T., DiBerto, Jeffrey F., Xiong, Yan, Urushihata, Takuya, Hirabayashi, Toshiyuki, Fujimoto, Atsushi, Mimura, Koki, English, Justin G., Liu, Jing, Inoue, Ken-ichi, Kumata, Katsushi, Seki, Chie, Ono, Maiko, Shimojo, Masafumi, Zhang, Ming-Rong, Tomita, Yutaka, Nakahara, Jin, Suhara, Tetsuya, Takada, Masahiko, Higuchi, Makoto, Jin, Jian, Roth, Bryan L., Minamimoto, Takafumi

“…The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling,…”
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