Search Results - "Englert, Joshua A"

Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome by Englert, Joshua A, Bobba, Christopher, Baron, Rebecca M

“…Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and mortality and arises after lung infection or infection at extrapulmonary…”
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Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis by Englert, Joshua A., MD, Rogers, Angela J., MD, MPH

“…Sepsis is characterized by profound changes in systemic and cellular metabolism that disrupt normal metabolic homeostasis. These metabolic changes can serve as…”
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Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation by Bobba, Christopher M., Fei, Qinqin, Shukla, Vasudha, Lee, Hyunwook, Patel, Pragi, Putman, Rachel K., Spitzer, Carleen, Tsai, MuChun, Wewers, Mark D., Lee, Robert J., Christman, John W., Ballinger, Megan N., Ghadiali, Samir N., Englert, Joshua A.

“…Mechanical ventilation generates injurious forces that exacerbate lung injury. These forces disrupt lung barrier integrity, trigger proinflammatory mediator…”
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Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury by Salazar‐Puerta, Ana I., Rincon‐Benavides, María A., Cuellar‐Gaviria, Tatiana Z., Aldana, Julian, Vasquez Martinez, Gabriela, Ortega‐Pineda, Lilibeth, Das, Devleena, Dodd, Daniel, Spencer, Charles A., Deng, Binbin, McComb, David W., Englert, Joshua A., Ghadiali, Samir, Zepeda‐Orozco, Diana, Wold, Loren E., Gallego‐Perez, Daniel, Higuita‐Castro, Natalia

“…Acute respiratory distress syndrome (ARDS) represents a significant burden to the healthcare system, with ≈200 000 cases diagnosed annually in the USA. ARDS…”
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Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation by Kim, Ji Young, Stevens, Patrick, Karpurapu, Manjula, Lee, Hyunwook, Englert, Joshua A, Yan, Pearlly, Lee, Tae Jin, Pabla, Navjot, Pietrzak, Maciej, Park, Gye Young, Christman, John W, Chung, Sangwoon

“…Asthma is phenotypically heterogeneous with several distinctive pathological mechanistic pathways. Previous studies indicate that neutrophilic asthma has a…”
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FoxO1 is a critical regulator of M2‐like macrophage activation in allergic asthma by Chung, Sangwoon, Kim, Ji Y., Song, Min‐Ae, Park, Gye Y., Lee, Yong G., Karpurapu, Manjula, Englert, Joshua A., Ballinger, Megan N., Pabla, Navjot, Chung, Hae Y., Christman, John W.

“…Background The pathogenesis of asthma and airway obstruction is the result of an abnormal response to different environmental exposures. The scientific premise…”
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Characterization of macroautophagic flux in vivo using a leupeptin-based assay by Haspel, Jeffrey, Shaik, Rahamthulla S., Ifedigbo, Emeka, Nakahira, Kiichi, Dolinay, Tamas, Englert, Joshua A., Choi, Augustine M.K.

“…Macroautophagy is a highly conserved catabolic process that is crucial for organ homeostasis in mammals. However, methods to directly measure macroautophagic…”
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SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure by Pannu, Sonal, Exline, Matthew C, Bednash, Joseph S, Englert, Joshua A, Diaz, Philip, Bartlett, Amy, Brock, Guy, Wu, Qing, Davis, Ian C, Crouser, Elliott D

“…The SARS CoV-2 pandemic has resulted in more than 1.1 million deaths in the USA alone. Therapeutic options for critically ill patients with COVID-19 are…”
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Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction by Ghanta, Sailaja, Tsoyi, Konstantin, Liu, Xiaoli, Nakahira, Kiichi, Ith, Bonna, Coronata, Anna A, Fredenburgh, Laura E, Englert, Joshua A, Piantadosi, Claude A, Choi, Augustine M K, Perrella, Mark A

“…Oxidative stress resulting from inflammatory responses that occur during acute lung injury and sepsis can initiate changes in mitochondrial function. Autophagy…”
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Longitudinal transcriptomic analysis reveals persistent enrichment of iron homeostasis and erythrocyte function pathways in severe COVID-19 ARDS by Eltobgy, Moemen, Johns, Finny, Farkas, Daniela, Leuenberger, Laura, Cohen, Sarah P, Ho, Kevin, Karow, Sarah, Swoope, Gabrielle, Pannu, Sonal, Horowitz, Jeffrey C, Mallampalli, Rama K, Englert, Joshua A, Bednash, Joseph S

“…The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-19 and contributes to patient morbidity and mortality. ARDS is a…”
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Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity by Englert, Joshua A, Macias, Alvaro A, Amador-Munoz, Diana, Pinilla Vera, Miguel, Isabelle, Colleen, Guan, Jiazhen, Magaoay, Brady, Suarez Velandia, Margarita, Coronata, Anna, Lee, Awapuhi, Fredenburgh, Laura E, Culley, Deborah J, Crosby, Gregory, Baron, Rebecca M

“…BACKGROUND:Isoflurane may be protective in preclinical models of lung injury, but its use in patients with lung injury remains controversial and the mechanism…”
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PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury by Nie, Yunjuan, Nirujogi, Teja Srinivas, Ranjan, Ravi, Reader, Brenda F., Chung, Sangwoon, Ballinger, Megan N., Englert, Joshua A., Christman, John W., Karpurapu, Manjula

“…Pulmonary macrophages play a critical role in the recognition of pathogens, initiation of host defense via inflammation, clearance of pathogens from the…”
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Semi-quantitative visual assessment of chest radiography is associated with clinical outcomes in critically ill patients by Mason, Stefanie E, Dieffenbach, Paul B, Englert, Joshua A, Rogers, Angela A, Massaro, Anthony F, Fredenburgh, Laura E, Higuera, Angelica, Pinilla-Vera, Mayra, Vilas, Marta, San Jose Estepar, Raul, Washko, George R, Baron, Rebecca M, Ash, Samuel Y

“…Respiratory pathology is a major driver of mortality in the intensive care unit (ICU), even in the absence of a primary respiratory diagnosis. Prior work has…”
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A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS by Fredenburgh, Laura E, Perrella, Mark A, Barragan-Bradford, Diana, Hess, Dean R, Peters, Elizabeth, Welty-Wolf, Karen E, Kraft, Bryan D, Harris, R Scott, Maurer, Rie, Nakahira, Kiichi, Oromendia, Clara, Davies, John D, Higuera, Angelica, Schiffer, Kristen T, Englert, Joshua A, Dieffenbach, Paul B, Berlin, David A, Lagambina, Susan, Bouthot, Mark, Sullivan, Andrew I, Nuccio, Paul F, Kone, Mamary T, Malik, Mona J, Porras, Maria Angelica Pabon, Finkelsztein, Eli, Winkler, Tilo, Hurwitz, Shelley, Serhan, Charles N, Piantadosi, Claude A, Baron, Rebecca M, Thompson, B Taylor, Choi, Augustine Mk

“…Acute respiratory distress syndrome (ARDS) is a prevalent disease with significant mortality for which no effective pharmacologic therapy exists. Low-dose…”
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Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation by Englert, Joshua A, Cho, Michael H, Lamb, Andrew E, Shumyatcher, Maya, Barragan-Bradford, Diana, Basil, Maria C, Higuera, Angelica, Isabelle, Colleen, Vera, Mayra Pinilla, Dieffenbach, Paul B, Fredenburgh, Laura E, Kang, Joyce B, Bhatt, Ami S, Antin, Joseph H, Ho, Vincent T, Soiffer, Robert J, Howrylak, Judie A, Himes, Blanca E, Baron, Rebecca M

“…The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting…”
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The upper and lower respiratory tract microbiome in severe aspiration pneumonia by Kitsios, Georgios D., Nguyen, Vi D., Sayed, Khaled, Al-Yousif, Nameer, Schaefer, Caitlin, Shah, Faraaz A., Bain, William, Yang, Haopu, Fitch, Adam, Li, Kelvin, Wang, Xiaohong, Qin, Shulin, Gentry, Heather, Zhang, Yingze, Varon, Jack, Arciniegas Rubio, Antonio, Englert, Joshua A., Baron, Rebecca M., Lee, Janet S., Methé, Barbara, Benos, Panayiotis V., Morris, Alison, McVerry, Bryan J.

“…Uncertainty persists whether anaerobic bacteria represent important pathogens in aspiration pneumonia. In a nested case-control study of mechanically…”
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Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock by Yang, Runkuan, Harada, Tomoyuki, Mollen, Kevin P, Prince, Jose M, Levy, Ryan M, Englert, Joshua A, Gallowitsch-Puerta, Margot, Yang, LiHong, Yang, Huan, Tracey, Kevin J, Harbrecht, Brian G, Billiar, Timothy R, Fink, Mitchell P

“…Intestinal barrier dysfunction occurs following hemorrhagic shock and resuscitation (HS/R). High-mobility group B1 (HMGB1) has been shown to increase the…”
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Kidney-lung cross talk during ARDS: mitochondrial DAMPs join the conversation by Varon, Jack, Englert, Joshua A

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mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury by Lee, Hyunwook, Fei, Qinqin, Streicher, Adam, Zhang, Wenjuan, Isabelle, Colleen, Patel, Pragi, Lam, Hilaire C, Arciniegas-Rubio, Antonio, Pinilla-Vera, Miguel, Amador-Munoz, Diana P, Barragan-Bradford, Diana, Higuera-Moreno, Angelica, Putman, Rachel K, Sholl, Lynette M, Henske, Elizabeth P, Bobba, Christopher M, Higuita-Castro, Natalia, Shalosky, Emily M, Hite, R Duncan, Christman, John W, Ghadiali, Samir N, Baron, Rebecca M, Englert, Joshua A

“…The acute respiratory distress syndrome (ARDS) is a highly lethal condition that impairs lung function and causes respiratory failure. Mechanical ventilation…”
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Pulmonary drug delivery for acute respiratory distress syndrome by Fei, Qinqin, Bentley, Ian, Ghadiali, Samir N., Englert, Joshua A.

“…The acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes respiratory failure. Despite numerous clinical trials, there are no…”
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