Search Results - "Engler, Melanie"

Senescence in RASopathies, a possible novel contributor to a complex pathophenoype by Engler, Melanie, Fidan, Miray, Nandi, Sayantan, Cirstea, Ion Cristian

“…[Display omitted] •Senescence is associated with ageing.•RAS-MAPK pathway has a major role in senescence.•Patients with RAS-MAPK developmental disorders…”
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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome by Busley, Alexandra Viktoria, Gutiérrez-Gutiérrez, Óscar, Hammer, Elke, Koitka, Fabian, Mirzaiebadizi, Amin, Steinegger, Martin, Pape, Constantin, Böhmer, Linda, Schroeder, Henning, Kleinsorge, Mandy, Engler, Melanie, Cirstea, Ion Cristian, Gremer, Lothar, Willbold, Dieter, Altmüller, Janine, Marbach, Felix, Hasenfuss, Gerd, Zimmermann, Wolfram-Hubertus, Ahmadian, Mohammad Reza, Wollnik, Bernd, Cyganek, Lukas

“…Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. In this…”
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Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model by Nandi, Sayantan, Chennappan, Saravanakkumar, Andrasch, Yannik, Fidan, Miray, Engler, Melanie, Ahmad, Mubashir, Tuckermann, Jan P., Zenker, Martin, Cirstea, Ion Cristian

“…RAS GTPases are ubiquitous GDP/GTP-binding proteins that function as molecular switches in cellular signalling and control numerous signalling pathways and…”
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Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks by Frappart, Pierre-Olivier, Kleger, Alexander, Breunig, Markus, Morawe, Mareen, Arnold, Frank, Gout, Johann, Engler, Melanie, Perkhofer, Lukas, Seufferlein, Thomas

“…Pancreatic ductal adenocarcinoma (PDAC) is still the Achilles heel in modern oncology, with an increasing incidence accompanied by a persisting high mortality…”
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The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth by Caratti, Bozhena, Fidan, Miray, Caratti, Giorgio, Breitenecker, Kristina, Engler, Melanie, Kazemitash, Naser, Traut, Rebecca, Wittig, Rainer, Casanova, Emilio, Ahmadian, Mohammad Reza, Tuckermann, Jan P, Moll, Herwig P, Cirstea, Ion Cristian

“…Mutations that activate members of the RAS family of GTPases are associated with various cancers and drive tumor growth. The glucocorticoid receptor (GR), a…”
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ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection by Engler, Melanie, Albers, Dan, Von Maltitz, Pascal, Groß, Rüdiger, Münch, Jan, Cirstea, Ion Cristian

“…SARS-CoV-2 triggered the most severe pandemic of recent times. To enter into a host cell, SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2)…”
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