Search Results - "Engle, Dannielle"

Altered glycosylation in pancreatic cancer and beyond by Lumibao, Jan C, Tremblay, Jacob R, Hsu, Jasper, Engle, Dannielle D

“…Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers and is projected to soon be the second leading cause of cancer death. Median survival of…”
Get full text

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts by Elyada, Ela, Bolisetty, Mohan, Laise, Pasquale, Flynn, William F, Courtois, Elise T, Burkhart, Richard A, Teinor, Jonathan A, Belleau, Pascal, Biffi, Giulia, Lucito, Matthew S, Sivajothi, Santhosh, Armstrong, Todd D, Engle, Dannielle D, Yu, Kenneth H, Hao, Yuan, Wolfgang, Christopher L, Park, Youngkyu, Preall, Jonathan, Jaffee, Elizabeth M, Califano, Andrea, Robson, Paul, Tuveson, David A

“…Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a…”
Get more information

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer by Öhlund, Daniel, Handly-Santana, Abram, Biffi, Giulia, Elyada, Ela, Almeida, Ana S, Ponz-Sarvise, Mariano, Corbo, Vincenzo, Oni, Tobiloba E, Hearn, Stephen A, Lee, Eun Jung, Chio, Iok In Christine, Hwang, Chang-Il, Tiriac, Hervé, Baker, Lindsey A, Engle, Dannielle D, Feig, Christine, Kultti, Anne, Egeblad, Mikala, Fearon, Douglas T, Crawford, James M, Clevers, Hans, Park, Youngkyu, Tuveson, David A

“…Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease…”
Get full text

A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer by Spike, Benjamin T., Engle, Dannielle D., Lin, Jennifer C., Cheung, Samantha K., La, Justin, Wahl, Geoffrey M.

“…Gene expression signatures relating mammary stem cell populations to breast cancers have focused on adult tissue. Here, we identify, isolate, and characterize…”
Get full text

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice by Engle, Dannielle D, Tiriac, Hervé, Rivera, Keith D, Pommier, Arnaud, Whalen, Sean, Oni, Tobiloba E, Alagesan, Brinda, Lee, Eun Jung, Yao, Melissa A, Lucito, Matthew S, Spielman, Benjamin, Da Silva, Brandon, Schoepfer, Christina, Wright, Kevin, Creighton, Brianna, Afinowicz, Lauren, Yu, Kenneth H, Grützmann, Robert, Aust, Daniela, Gimotty, Phyllis A, Pollard, Katherine S, Hruban, Ralph H, Goggins, Michael G, Pilarsky, Christian, Park, Youngkyu, Pappin, Darryl J, Hollingsworth, Michael A, Tuveson, David A

“…Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely…”
Get full text

Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer by Quaranta, Valeria, Rainer, Carolyn, Nielsen, Sebastian R, Raymant, Meirion L, Ahmed, Muhammad S, Engle, Dannielle D, Taylor, Arthur, Murray, Trish, Campbell, Fiona, Palmer, Daniel H, Tuveson, David A, Mielgo, Ainhoa, Schmid, Michael C

“…The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune…”
Get full text

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression by Seifert, Lena, Werba, Gregor, Tiwari, Shaun, Giao Ly, Nancy Ngoc, Alothman, Sara, Alqunaibit, Dalia, Avanzi, Antonina, Barilla, Rocky, Daley, Donnele, Greco, Stephanie H., Torres-Hernandez, Alejandro, Pergamo, Matthew, Ochi, Atsuo, Zambirinis, Constantinos P., Pansari, Mridul, Rendon, Mauricio, Tippens, Daniel, Hundeyin, Mautin, Mani, Vishnu R., Hajdu, Cristina, Engle, Dannielle, Miller, George

“…A study of pancreatic ductal adenocarcinoma shows that cancer cell proliferation is associated with increased expression of proteins that control programmed…”
Get full text

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis by Nielsen, Sebastian R., Quaranta, Valeria, Linford, Andrea, Emeagi, Perpetua, Rainer, Carolyn, Santos, Almudena, Ireland, Lucy, Sakai, Takao, Sakai, Keiko, Kim, Yong-Sam, Engle, Dannielle, Campbell, Fiona, Palmer, Daniel, Ko, Jeong Heon, Tuveson, David A., Hirsch, Emilio, Mielgo, Ainhoa, Schmid, Michael C.

“…Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which better therapies are urgently needed. Macrophages enhance metastasis in…”
Get full text

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis by Zambirinis, Constantinos P, Levie, Elliot, Nguy, Susanna, Avanzi, Antonina, Barilla, Rocky, Xu, Yijie, Seifert, Lena, Daley, Donnele, Greco, Stephanie H, Deutsch, Michael, Jonnadula, Saikiran, Torres-Hernandez, Alejandro, Tippens, Daniel, Pushalkar, Smruti, Eisenthal, Andrew, Saxena, Deepak, Ahn, Jiyoung, Hajdu, Cristina, Engle, Dannielle D, Tuveson, David, Miller, George

“…Modulation of Toll-like receptor (TLR) signaling can have protective or protumorigenic effects on oncogenesis depending on the cancer subtype and on specific…”
Get full text

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer by Ponz-Sarvise, Mariano, Corbo, Vincenzo, Tiriac, Hervé, Engle, Dannielle D, Frese, Kristopher K, Oni, Tobiloba E, Hwang, Chang-Il, Öhlund, Daniel, Chio, Iok In Christine, Baker, Lindsey A, Filippini, Dea, Wright, Kevin, Bapiro, Tashinga E, Huang, Pearl, Smith, Paul, Yu, Kenneth H, Jodrell, Duncan I, Park, Youngkyu, Tuveson, David A

“…is mutated in the majority of pancreatic ductal adenocarcinoma. MAPK and PI3K-AKT are primary KRAS effector pathways, but combined MAPK and PI3K inhibition has…”
Get full text

Organoid Models of Human and Mouse Ductal Pancreatic Cancer by Boj, Sylvia F., Hwang, Chang-Il, Baker, Lindsey A., Chio, Iok In Christine, Engle, Dannielle D., Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S., Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H., van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D., Wilson, John P., Feigin, Michael E., Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M., Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N., Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H.M., Molenaar, I. Quintus, Borel Rinkes, Inne H., Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J., Iacobuzio-Donahue, Christine, Leach, Steven D., Pappin, Darryl J., Hammell, Molly, Klimstra, David S., Basturk, Olca, Hruban, Ralph H., Offerhaus, George Johan, Vries, Robert G.J., Clevers, Hans, Tuveson, David A.

“…Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and…”
Get full text

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy by Sherman, Mara H., Yu, Ruth T., Engle, Dannielle D., Ding, Ning, Atkins, Annette R., Tiriac, Herve, Collisson, Eric A., Connor, Frances, Van Dyke, Terry, Kozlov, Serguei, Martin, Philip, Tseng, Tiffany W., Dawson, David W., Donahue, Timothy R., Masamune, Atsushi, Shimosegawa, Tooru, Apte, Minoti V., Wilson, Jeremy S., Ng, Beverly, Lau, Sue Lynn, Gunton, Jenny E., Wahl, Geoffrey M., Hunter, Tony, Drebin, Jeffrey A., O’Dwyer, Peter J., Liddle, Christopher, Tuveson, David A., Downes, Michael, Evans, Ronald M.

“…The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to intrinsic chemoresistance and a growth-permissive tumor microenvironment…”
Get full text

Inhibiting stromal Class I HDACs curbs pancreatic cancer progression by Liang, Gaoyang, Oh, Tae Gyu, Hah, Nasun, Tiriac, Hervé, Shi, Yu, Truitt, Morgan L., Antal, Corina E., Atkins, Annette R., Li, Yuwenbin, Fraser, Cory, Ng, Serina, Pinto, Antonio F. M., Nelson, Dylan C., Estepa, Gabriela, Bashi, Senada, Banayo, Ester, Dai, Yang, Liddle, Christopher, Yu, Ruth T., Hunter, Tony, Engle, Dannielle D., Han, Haiyong, Von Hoff, Daniel D., Downes, Michael, Evans, Ronald M.

“…Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic…”
Get full text

Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma by Gulay, Kevin Christian Montecillo, Zhang, Xinlian, Pantazopoulou, Vasiliki, Patel, Jay, Esparza, Edgar, Pran Babu, Deepa Sheik, Ogawa, Satoshi, Weitz, Jonathan, Ng, Isabella, Mose, Evangeline S, Pu, Minya, Engle, Dannielle D, Lowy, Andrew M, Tiriac, Hervé

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a low survival rate. Recently, new drugs that target KRASG12D, a common mutation in PDAC, have…”
Get full text

SIRT1-NOX4 signaling axis regulates cancer cachexia by Dasgupta, Aneesha, Shukla, Surendra K, Vernucci, Enza, King, Ryan J, Abrego, Jaime, Mulder, Scott E, Mullen, Nicholas J, Graves, Gavin, Buettner, Kyla, Thakur, Ravi, Murthy, Divya, Attri, Kuldeep S, Wang, Dezhen, Chaika, Nina V, Pacheco, Camila G, Rai, Ibha, Engle, Dannielle D, Grandgenett, Paul M, Punsoni, Michael, Reames, Bradley N, Teoh-Fitzgerald, Melissa, Oberley-Deegan, Rebecca, Yu, Fang, Klute, Kelsey A, Hollingsworth, Michael A, Zimmerman, Matthew C, Mehla, Kamiya, Sadoshima, Junichi, Tuveson, David A, Singh, Pankaj K

“…Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic…”
Get full text

P53 Mutations Change Phosphatidylinositol Acyl Chain Composition by Naguib, Adam, Bencze, Gyula, Engle, Dannielle D., Chio, Iok I.C., Herzka, Tali, Watrud, Kaitlin, Bencze, Szilvia, Tuveson, David A., Pappin, Darryl J., Trotman, Lloyd C.

“…Phosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal…”
Get full text

A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer by Antal, Corina E., Oh, Tae Gyu, Aigner, Stefan, Luo, En-Ching, Yee, Brian A., Campos, Tania, Tiriac, Hervé, Rothamel, Katherine L., Cheng, Zhang, Jiao, Henry, Wang, Allen, Hah, Nasun, Lenkiewicz, Elizabeth, Lumibao, Jan C., Truitt, Morgan L., Estepa, Gabriela, Banayo, Ester, Bashi, Senada, Esparza, Edgar, Munoz, Ruben M., Diedrich, Jolene K., Sodir, Nicole M., Mueller, Jasmine R., Fraser, Cory R., Borazanci, Erkut, Propper, David, Von Hoff, Daniel D., Liddle, Christopher, Yu, Ruth T., Atkins, Annette R., Han, Haiyong, Lowy, Andrew M., Barrett, Michael T., Engle, Dannielle D., Evan, Gerard I., Yeo, Gene W., Downes, Michael, Evans, Ronald M.

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as…”
Get full text

Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury by Tremblay, Jacob R, Ortiz, Jose A, Quijano, Janine C, Zook, Heather N, Erdem, Neslihan, LeBon, Jeanne M, Li, Wendong, Jou, Kevin, Tsark, Walter, Mann, Jeffrey R, Kozlowski, Mark T, Tirrell, David A, Esni, Farzad, Engle, Dannielle D, Riggs, Arthur D, Ku, Hsun Teresa

“…Pancreatic ductal progenitor cells have been proposed to contribute to adult tissue maintenance and regeneration after injury, but the identity of such ductal…”
Get full text

Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling by Roy, Ishan, McAllister, Donna M, Gorse, Egal, Dixon, Kate, Piper, Clinton T, Zimmerman, Noah P, Getschman, Anthony E, Tsai, Susan, Engle, Dannielle D, Evans, Douglas B, Volkman, Brian F, Kalyanaraman, Balaraman, Dwinell, Michael B

“…Patients with pancreatic ductal adenocarcinoma (PDAC) invariably succumb to metastatic disease, but the underlying mechanisms that regulate PDAC cell movement…”
Get full text

The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids by Lumibao, Jan C, Okhovat, Shira R, Peck, Kristina L, Lin, Xiaoxue, Lande, Kathryn, Yomtoubian, Shira, Ng, Isabella, Tiriac, Hervé, Lowy, Andrew M, Zou, Jingjing, Engle, Dannielle D

“…The use of patient-derived organoids (PDOs) to characterize therapeutic sensitivity and resistance is a promising precision medicine approach, and its…”
Get full text