Search Results - "Engelstoft, Maja S"

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes by Nøhr, Mark K, Pedersen, Maria H, Gille, Andreas, Egerod, Kristoffer L, Engelstoft, Maja S, Husted, Anna Sofie, Sichlau, Rasmus M, Grunddal, Kaare V, Seier Poulsen, Steen, Han, Sangdon, Jones, Robert M, Offermanns, Stefan, Schwartz, Thue W

“…The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of…”
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Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites by Lund, Mari L., Egerod, Kristoffer L., Engelstoft, Maja S., Dmytriyeva, Oksana, Theodorsson, Elvar, Patel, Bhavik A., Schwartz, Thue W.

“…5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons…”
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The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo by Panaro, Brandon L., Tough, Iain R., Engelstoft, Maja S., Matthews, Robert T., Digby, Gregory J., Møller, Cathrine L., Svendsen, Berit, Gribble, Fiona, Reimann, Frank, Holst, Jens J., Holst, Birgitte, Schwartz, Thue W., Cox, Helen M., Cone, Roger D.

“…The melanocortin-4 receptor (MC4R) is expressed in the brainstem and vagal afferent nerves and regulates a number of aspects of gastrointestinal function. Here…”
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Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells by Engelstoft, Maja S, Lund, Mari L, Grunddal, Kaare V, Egerod, Kristoffer L, Osborne-Lawrence, Sherri, Poulsen, Steen Seier, Zigman, Jeffrey M, Schwartz, Thue W

“…Chromogranin A (ChgA) is an acidic protein found in large dense-core secretory vesicles and generally considered to be expressed in all enteroendocrine cells…”
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Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G‑Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions by Frimurer, Thomas M, Mende, Franziska, Graae, Anne-Sofie, Engelstoft, Maja S, Egerod, Kristoffer L, Nygaard, Rie, Gerlach, Lars-Ole, Hansen, Jakob Bondo, Schwartz, Thue W, Holst, Birgitte

“…The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn2+. We used a homology model-based approach to identify small-molecule…”
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Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors by Holst, Birgitte, Nygaard, Rie, Valentin-Hansen, Louise, Bach, Anders, Engelstoft, Maja S, Petersen, Pia S, Frimurer, Thomas M, Schwartz, Thue W

“…The conserved tryptophan in position 13 of TM-VI (Trp-VI:13 or Trp-6.48) of the CWXP motif located at the bottom of the main ligand-binding pocket in TM-VI is…”
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Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice by Jørgensen, Mette C., de Lichtenberg, Kristian H., Collin, Caitlin A., Klinck, Rasmus, Ekberg, Jeppe H., Engelstoft, Maja S., Lickert, Heiko, Serup, Palle

“…ABSTRACT Mutations in Hes1, a target gene of the Notch signalling pathway, lead to ectopic pancreas by a poorly described mechanism. Here, we use genetic…”
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Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells by Grunddal, Kaare V., Tonack, Sarah, Egerod, Kristoffer L., Thompson, Jonathan James, Petersen, Natalia, Engelstoft, Maja S., Vagne, Constance, Keime, Céline, Gradwohl, Gérard, Offermanns, Stefan, Schwartz, Thue W.

“…GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation…”
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Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production by Piccand, Julie, Vagne, Constance, Blot, Florence, Meunier, Aline, Beucher, Anthony, Strasser, Perrine, Lund, Mari L., Ghimire, Sabitri, Nivlet, Laure, Lapp, Céline, Petersen, Natalia, Engelstoft, Maja S., Thibault-Carpentier, Christelle, Keime, Céline, Correa, Sara Jimenez, Schreiber, Valérie, Molina, Nacho, Schwartz, Thue W., De Arcangelis, Adèle, Gradwohl, Gérard

“…Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy…”
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Enteroendocrine cell types revisited by Engelstoft, Maja S, Egerod, Kristoffer L, Lund, Mari L, Schwartz, Thue W

“…Graphical abstract…”
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A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin by Egerod, Kristoffer L, Engelstoft, Maja S, Grunddal, Kaare V, Nøhr, Mark K, Secher, Anna, Sakata, Ichiro, Pedersen, Jens, Windeløv, Johanne A, Füchtbauer, Ernst-Martin, Olsen, Jørgen, Sundler, Frank, Christensen, Jan P, Wierup, Nils, Olsen, Jesper V, Holst, Jens J, Zigman, Jeffrey M, Poulsen, Steen S, Schwartz, Thue W

“…Enteroendocrine cells such as duodenal cholecystokinin (CCK cells) are generally thought to be confined to certain segments of the gastrointestinal (GI) tract…”
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GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40) by Ekberg, Jeppe H, Hauge, Maria, Kristensen, Line V, Madsen, Andreas N, Engelstoft, Maja S, Husted, Anna-Sofie, Sichlau, Rasmus, Egerod, Kristoffer L, Timshel, Pascal, Kowalski, Timothy J, Gribble, Fiona M, Reiman, Frank, Hansen, Harald S, Howard, Andrew D, Holst, Birgitte, Schwartz, Thue W

“…Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G Protein-coupled Receptor…”
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Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism by Grunddal, Kaare V, Ratner, Cecilia F, Svendsen, Berit, Sommer, Felix, Engelstoft, Maja S, Madsen, Andreas N, Pedersen, Jens, Nøhr, Mark K, Egerod, Kristoffer L, Nawrocki, Andrea R, Kowalski, Timothy, Howard, Andrew D, Poulsen, Steen Seier, Offermanns, Stefan, Bäckhed, Fredrik, Holst, Jens J, Holst, Birgitte, Schwartz, Thue W

“…The 2 gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are well known to be coexpressed, costored, and released together to coact in the…”
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Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice by Jepsen, Sara L, Grunddal, Kaare V, Wewer Albrechtsen, Nicolai J, Engelstoft, Maja S, Gabe, Maria B N, Jensen, Elisa P, Ørskov, Cathrine, Poulsen, Steen S, Rosenkilde, Mette M, Pedersen, Jens, Gribble, Fiona M, Reimann, Frank, Deacon, Carolyn F, Schwartz, Thue W, Christ, Andreas D, Martin, Rainer E, Holst, Jens J

“…DPP-4 inhibitors, used for treatment of type 2 diabetes, act by increasing the concentrations of intact glucagon-like peptide-1 (GLP-1), but at the same time,…”
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Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells by Egerod, Kristoffer L, Engelstoft, Maja S, Lund, Mari L, Grunddal, Kaare V, Zhao, Mirabella, Barir-Jensen, Dominique, Nygaard, Eva B, Petersen, Natalia, Holst, Jens J, Schwartz, Thue W

“…In the stomach, somatostatin (SST) acts as a general paracrine negative regulator of exocrine secretion of gastric acid and pepsinogen and endocrine secretion…”
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GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo by Hauge, Maria, Vestmar, Marie A, Husted, Anna S, Ekberg, Jeppe P, Wright, Michael J, Di Salvo, Jerry, Weinglass, Adam B, Engelstoft, Maja S, Madsen, Andreas N, Lückmann, Michael, Miller, Michael W, Trujillo, Maria E, Frimurer, Thomas M, Holst, Birgitte, Howard, Andrew D, Schwartz, Thue W

“…Abstract Objectives GPR40 (FFAR1), a clinically proven anti-diabetes target, is a Gq-coupled receptor for long chain fatty acids (LCFA) stimulating insulin…”
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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells by Engelstoft, Maja S, Park, Won-mee, Sakata, Ichiro, Kristensen, Line V, Husted, Anna Sofie, Osborne-Lawrence, Sherri, Piper, Paul K, Walker, Angela K, Pedersen, Maria H, Nøhr, Mark K, Pan, Jie, Sinz, Christopher J, Carrington, Paul E, Akiyama, Taro E, Jones, Robert M, Tang, Cong, Ahmed, Kashan, Offermanns, Stefan, Egerod, Kristoffer L, Zigman, Jeffrey M, Schwartz, Thue W

“…Abstract The molecular mechanisms regulating secretion of the orexigenic-glucoregulatory hormone ghrelin remain unclear. Based on qPCR analysis of…”
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GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness by Svendsen, Berit, Pais, Ramona, Engelstoft, Maja S, Milev, Nikolay B, Richards, Paul, Christiansen, Charlotte B, Egerod, Kristoffer L, Jensen, Signe M, Habib, Abdella M, Gribble, Fiona M, Schwartz, Thue W, Reimann, Frank, Holst, Jens J

“…The incretin hormones glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from intestinal endocrine cells, the…”
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The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones by Rudenko, Olga, Shang, Jin, Munk, Alexander, Ekberg, Jeppe P., Petersen, Natalia, Engelstoft, Maja S., Egerod, Kristoffer L., Hjorth, Siv A., Wu, Margaret, Feng, Yue, Zhou, Yun-Ping, Mokrosinski, Jacek, Thams, Peter, Reimann, Frank, Gribble, Fiona, Rehfeld, Jens F., Holst, Jens J., Treebak, Jonas T., Howard, Andrew D., Schwartz, Thue W.

“…GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role…”
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Model-Based Discovery of Synthetic Agonists for the Zn 2+ -Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions by Frimurer, Thomas M, Mende, Franziska, Graae, Anne-Sofie, Engelstoft, Maja S, Egerod, Kristoffer L, Nygaard, Rie, Gerlach, Lars-Ole, Hansen, Jakob Bondo, Schwartz, Thue W, Holst, Birgitte

“…The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn . We used a homology model-based approach to identify small-molecule…”
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